The Fate of Toxicological Studies: From Animal Models to Stem Cell-based Methods
- Authors: Uzair Ahmed1,2, Usman Ali Ashfaq3, Muhammad Qasim4, Mahmood -u-Rahman5, Saba Khaliq6, Muhammad Tariq7, Rashid Bhatti8, Muhammad Shareef Masoud9
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View Affiliations Hide Affiliations1 Shenzhen Key Laboratory of Biomimetic Materials and Cellular Immunomodulation, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy ofSciences, Shenzhen, China 2 University of Chinese Academy of Sciences, Beijing, China 3 Department of Bioinformatics and Biotechnology, Government College University Faisalabad, Faisalabad 38000, Punjab, Pakistan 4 Department of Bioinformatics and Biotechnology, Government College University Faisalabad, Faisalabad 38000, Punjab, Pakistan 5 Department of Bioinformatics and Biotechnology, Government College University Faisalabad, Faisalabad 38000, Punjab, Pakistan 6 Department of Physiology and Cell Biology, University of Health Sciences, Lahore, Pakistan 7 Department of Biotechnology, Mirpur University of Science and Technology, Mirpur, AJK, Pakistan 8 National Center of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan 9 Department of Bioinformatics and Biotechnology, Government College University Faisalabad, Faisalabad 38000, Punjab, Pakistan
- Source: Frontiers in Stem Cell and Regenerative Medicine Research: Volume 10 , pp 103-122
- Publication Date: March 2022
- Language: English
The Fate of Toxicological Studies: From Animal Models to Stem Cell-based Methods, Page 1 of 1
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After the development of a new drug, it is compulsory to test its benefits aswell as toxic effects before human implementation. In the past, animals were beingused as standard models for drug toxicity testing, but animal testing arose many ethicalconcerns and controversies. To overcome these ethical hurdles, many non-animaltoxicity models were developed to cope with the drug toxicity analysis, but certainlimitations like interspecies barriers do not make them good models for drug toxicitystudies.-. Due to their self-renewal and capacity to divide into multiple cell lineages,such as hepatocytes, cardiomyocytes, and neural cells, stem cells are being used toestablish alternative approaches for toxicological studies. This makes them a potentialresource in predictive toxicological studies without the limitations of interspeciesboundaries. In-vitro toxicological models, such as Adult Stem Cells (ASCs),Embryonic Stem Cells (ESCs), and recently established Induced Pluripotent Stem Cells(iPSCs) are currently being used as alternatives to animal models. This chapter willdiscuss the journey of toxicity studies from animal models to in vitro stem cell-basedtoxicity models.
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