Short Non-coding RNAs: Promising Biopharmaceutical Weapons in Breast Carcinogenesis
- Authors: Rana Ahmed Youness1, Mohamed Zakaria Gad2
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View Affiliations Hide Affiliations1 Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, New Cairo City, Main Entrance Al Tagamoa Al Khames, 11835, Cairo, Egypt 2 (2) Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, New Cairo City, Main Entrance Al Tagamoa Al Khames, 11835, Cairo, Egypt
- Source: Advances in Cancer Nanotheranostics for Experimental and Personalized Medicine , pp 116-130
- Publication Date: June 2020
- Language: English
Short Non-coding RNAs: Promising Biopharmaceutical Weapons in Breast Carcinogenesis, Page 1 of 1
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Despite being previously annotated as 'junk' transcriptional products, the non-coding RNA molecules (ncRNAs) have proven their indisputable role in carcinogenesis. ncRNAs are believed to act as potent oncogenic mediators or tumor suppressors in different contexts in oncology. Functionally, ncRNAs are able to modulate various processes in the cell such as chromatin re-modeling, transcription, post-transcriptional modifications and especially signal transduction. The most abundant and well-studied ncRNA molecules are the microRNAs (miRNAs/miRs). Different oncogenic signaling cascades have recently been in relation with miRNAs in a bi-directional crosstalk. Thus, this chapter offers a wider perspective towards complex networks of interactions coordinated by miRNAs specifically in Breast Cancer (BC). Nonetheless, this chapter also sheds the light onto clinical status of the miRNAs as a potential therapeutic intervention in several contexts.
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