Major Metabolites of Certain Marketed Plant Alkaloids
- Authors: Kuntal Manna1, Bikash Debnath2, Waikhom Somraj Singh3
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View Affiliations Hide Affiliations1 Natural cum Advance Synthetic Lab, Department of Pharmacy, Tripura University (A Central University), Suryamaninagar, Tripura, India 2 Natural cum Advance Synthetic Lab, Department of Pharmacy, Tripura University (A Central University), Suryamaninagar, Tripura, India 3 Natural cum Advance Synthetic Lab, Department of Pharmacy, Tripura University (A Central University), Suryamaninagar, Tripura, India
- Source: Frontiers in Natural Product Chemistry: Volume 6 , pp 124-150
- Publication Date: August 2020
- Language: English
Major Metabolites of Certain Marketed Plant Alkaloids, Page 1 of 1
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The archeological and historical record shows that people across Asia, Europe, and Africa used alkaloidal drugs as early as 2000 BCE. Alkaloids are heterocyclic rings consisting of at least one nitrogen atom. They are the waste products of plant metabolites and serve a wide variety of biological activities to human beings. Nicotine, cytosine, atropine, scopolamine, cocaine, catuabine, quinine, quinidine, dihydroquinine, papaverine, ephedrine, reserpine, ergotamine, caffeine, etc. are the most important marketed plant alkaloidal drugs and their metabolites are described in this chapter. Metabolism plays a central role in regulating the toxicity of a variety of phytochemicals. Hepatic microsomal enzymes such as monooxygenase and putative NADPH-FMN-reductase, carboxyl esterase, CYP2B6, CYP3A4, and CYP2D6 are mostly involved in the metabolism of alkaloids. This chapter will be important for future researchers.
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