(E)-N-Methyl-1-(Methylthio)-2-Nitroethenamine (Nmsm) as a Versatile Ambiphilic Synthon in Organic Synthesis
- Authors: Pedavenkatagari Narayana Reddy1, Pannala Padmaja2
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View Affiliations Hide Affiliations1 Department of Chemistry, School of Science, Gitam University, Hyderabad, India 2 Department of Chemistry, School of Science, Gitam University, Hyderabad, India
- Source: Advances in Organic Synthesis: Volume 13 , pp 273-310
- Publication Date: November 2020
- Language: English
(E)-N-Methyl-1-(Methylthio)-2-Nitroethenamine (Nmsm) as a Versatile Ambiphilic Synthon in Organic Synthesis, Page 1 of 1
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(E)-N-methyl-1-(methylthio)-2-nitroethenamine (NMSM) 1 is a versatile molecule that contains four active sites with three functional groups on an ethane motif. NMSM as a precursor reactant has been widely applied in the diversity-oriented synthesis of various heterocyclic motifs, bis-heterocyclic, fused heterocyclic and spirocyclic scaffolds. These privileged scaffolds were synthesized via numerous types of reactions, such as Michael addition, 1,3-dipolar cycloaddition, heteroannulation reaction and also many cascade reactions via multi-component reactions. Moreover, the flexibility and high reactivity of NMSM as a versatile ambiphilic synthon signify it as a suitable building block in medicinal chemistry and bulk drug synthesis. In the present book chapter, we focused on the advances in the chemistry of NMSM as an effective reagent in organic synthesis.
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