Coumarin Derivatives as Potential Antiinflammatory Agents for Drug Development
- Authors: Abdul Jalil Shah1, Reyaz Hassan Mir2, Roohi Mohi-ud-din3, Saba Hussain Sabreen4, Nazia Banday5, Mudasir Maqbool Bhat6, Mubashir Hussain Masoodi7
-
View Affiliations Hide Affiliations1 Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar 190006, Kashmir, India 2 Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar-190006, Kashmir, India 3 Pharmacognosy Division, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar, 190006, Kashmir, India 4 Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar-190006, Kashmir, India 5 Pharmacognosy Division, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar, 190006, Kashmir, India 6 Pharmacy Practice Division, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar, 190006, Kashmir, India 7 Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar-190006, Kashmir, India
- Source: Frontiers in Natural Product Chemistry: Volume 8 , pp 213-238
- Publication Date: December 2021
- Language: English
Coumarin Derivatives as Potential Antiinflammatory Agents for Drug Development, Page 1 of 1
< Previous page | Next page > /docserver/preview/fulltext/9781681089379/chapter-6-1.gif
The search for anti-inflammatory drugs is still challenging, even though recent advances in modern medicine have provided some relief. Coumarins, well known secondary metabolites widely distributed in plant kingdom, have successfully documented their candidature in the development of anti-inflammatory agents. Natural coumarins, including esculetin, umbelliferone, scopoletin and marmin showed potent anti-inflammatory activity through various targets, including COX-2, LOX, iNOS TNF-α, TXB2. Over the past decade, various synthetic modifications have been carried out on the scaffold of these natural products. The current review focuses on various synthetic and semi-synthetic modifications carried out on the coumarin nucleus with a primary focus on the evaluation of anti-inflammatory activity along with structureactivity relationship study.
-
From This Site
/content/books/9781681089379.chapter-6dcterms_subject,pub_keyword-contentType:Journal -contentType:Figure -contentType:Table -contentType:SupplementaryData105
