Pradimicin and Benanomicin Antibiotics: From Antifungal Polyketide Natural Products to Antiviral Agents with a Unique Carbohydrate- Binding Mode of Action
- Authors: Rocío Abín1, Visitación López-Miranda2, Ana San-Félix3, Ernesto Quesada4
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View Affiliations Hide Affiliations1 Instituto de Qumica Mdica (IQM), Dpt. of Biomimetics for Drug Discovery, Agencia Estatal Consejo Superior de Investigaciones Cientficas (AE CSIC), Madrid, Spain 2 rea de Farmacologa y Nutricin, Departamento de Ciencias Bsicas de la Salud, Universidad Rey Juan Carlos (URJC), Alcorcn, Spain 3 Instituto de Qumica Mdica (IQM), Dpt. of Biomimetics for Drug Discovery, Agencia Estatal Consejo Superior de Investigaciones Cientficas (AE-CSIC), Madrid, Spain 4 Instituto de Qumica Mdica (IQM), Dpt. of Biomimetics for Drug Discovery, Agencia Estatal Consejo Superior de Investigaciones Cientficas (AE-CSIC), Madrid, Spain
- Source: Frontiers in Natural Product Chemistry: Volume 7 , pp 31-109
- Publication Date: November 2021
- Language: English
Pradimicin and Benanomicin Antibiotics: From Antifungal Polyketide Natural Products to Antiviral Agents with a Unique Carbohydrate- Binding Mode of Action, Page 1 of 1
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The family of benanomicin-pradimicin antibiotics (BPAs) is reviewed exhaustively with respect to its structural, functional, mechanistic and synthetic aspects. BPAs can be considered a unique class of compounds from the structural point of view due to the presence of a 5,6-dihydro-benzo[α]naphthacenequinone (DHBNQ) scaffold attached to a glycan moiety. The mechanism of action is lectin-like and related to the selective recognition and binding to specific mannoside residues located at the surface of the membrane of fungal and viral pathogens. BPAs are prototype structures of non-peptidic small-size carbohydrate-binding agents (CBAs).
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