CAR-T Cells in Brain Tumors and Autoimmune Diseases from Basics to the Clinic
- Authors: Mansour Poorebrahim1, Niloufar Mohammadkhani2, Mohammad Foad Abazari3, Elham Fakhr4, Isaac Quiros Fernandez5, Solmaz Sadeghi6, Angel Cid-Arregui7
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View Affiliations Hide Affiliations1 Targeted Tumor Vaccines Group, Clinical Cooperation Unit Applied Tumor Immunity, German Cancer Research Center (DKFZ), Heidelberg, Germany 2 Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran 3 Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran 4 Faculty of Biosciences, Heidelberg University, 69120 Heidelberg, Germany 5 Targeted Tumor Vaccines Group, Clinical Cooperation Unit Applied Tumor Immunity, German Cancer Research Center (DKFZ), Heidelberg, Germany 6 Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran 7 Targeted Tumor Vaccines Group, Clinical Cooperation Unit Applied Tumor Immunity, German Cancer Research Center (DKFZ), Heidelberg, Germany
- Source: Frontiers in Clinical Drug Research - CNS and Neurological Disorders: Volume 9 , pp 65-89
- Publication Date: October 2021
- Language: English
CAR-T Cells in Brain Tumors and Autoimmune Diseases from Basics to the Clinic, Page 1 of 1
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Chimeric antigen receptor (CAR)-T cell therapy has recently been introduced as a promising therapeutic T cell-based therapy. Autologous T cells are collected from the patient, engineered in vitro to express artificial chimeric receptors against a specific tumor antigen, and infused into the patient. The success of adoptive CAR-T cells for cancer immunotherapies, particularly in hematological malignancies, inspired researchers of the field. These armored T cells also showed a great potential to be used in the treatment of pediatric brain tumors and autoimmune diseases. In this chapter, we summarize the basics and developments of CAR-T cells from our previous review articles and then discuss the current progress in the pre-clinical and clinical application of CAR-T cells in brain tumors and autoimmune diseases.
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