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Unusual Clinical Aspects of Vitamin Hypersensitivity

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Although immediate-type hypersensitivity and allergic contact dermatitis have been mainly reported following vitamins or multivitamins intake and exposure respectively, more rarely unusual immune-mediated adverse reactions such as fixed drug eruption and other more serious hypersensitivity syndrome are described in the literature, but their diagnostic approach is more difficult because skin tests in severe cutaneous adverse reactions are validated for few drugs as anti-convulsivant agents.

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