Perspectives in 11C and 18F Radiochemistry
- Authors: Hugo Helbert1, Gert Luurtsema2, Rudi A.J.O. Dierckx3, Wiktor Szymanski4, Ben L. Feringa5, Philip H. Elsinga6
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View Affiliations Hide Affiliations1 Department of Nuclear Medicine and Molecular Imaging, Medical Imaging Center, University ofGroningen, University Medical Center Groningen, The Netherlands | Nobel Laureate Chemistry 2016, Stratingh Institute for Chemistry, University of Groningen, TheNetherlands 2 Department of Nuclear Medicine and Molecular Imaging, Medical Imaging Center, University ofGroningen, University Medical Center Groningen, The Netherlands 3 Department of Nuclear Medicine and Molecular Imaging, Medical Imaging Center, University ofGroningen, University Medical Center Groningen, The Netherlands 4 Nobel Laureate Chemistry 2016, Stratingh Institute for Chemistry, University of Groningen, TheNetherlands | Department of Radiology, Medical Imaging Center, University of Groningen, University MedicalCenter Groningen, The Netherlands 5 Nobel Laureate Chemistry 2016, Stratingh Institute for Chemistry, University of Groningen, TheNetherlands 6 Department of Nuclear Medicine and Molecular Imaging, Medical Imaging Center, University ofGroningen, University Medical Center Groningen, The Netherlands
- Source: The Evolution of Radionanotargeting towards Clinical Precision Oncology: A Festschrift in Honor of Kalevi Kairemo , pp 19-31
- Publication Date: March 2022
- Language: English
The state-of-the-art of carbon-11 and fluorine-18 radiochemistry for positron emission tomography (PET) is presented. From the latest developments in labelling methodology, a picture of future challenges is drawn. The exploration of novel reactivity to allow 11C-labelling, alongside a particular focus in making such reaction compatible for clinical production, is presented to be key in 11C-tracer discovery. 18F is envisioned to be at the heart of further development in PET. Broadening imaging strategies towards pre-targeting approaches, together with the use of modified antibodies or peptides, constantly challenges the field of radiofluorination for new and efficient labelling methods applicable to complex molecules. Translation of biorthogonal reactions into radiolabelling methods appears as a valuable option to address these issues and is expected to be a significant advance in upcoming 18F-tracer developments.
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