[99mTc]Tc-MIBI as Oncologic Radiotracer

Latest advances in PET imaging, the growing importance of the theragnostic approach and the inclusion of 18F-FDG in the staging guidelines of many oncological situations put in shadow the research on SPECT radiopharmaceuticals, including those considered classic as having oncological tropism. However, there are studies, some of them very recent, that highlight an important role of MIBI in cancer imaging and management. The dynamics of uptake and the wash-out process differ depending on the cellular metabolism and can be used for various indications, one of them being differentiation of malignant processes or predict chemotherapy resistance. In this paper, we will review the literature and present most important actual and potential application of 99m-Tc-MIBI scan in oncologic diseases.