Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Drug Delivery Applications
- Authors: Gabriel Silva Borges1, Mariana Silva Oliveira2, Délia Chaves Moreira dos Santos3, Lucas Antônio Miranda Ferreira4, Guilherme Carneiro5
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View Affiliations Hide Affiliations1 Department of Pharmaceutics, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil 2 Department of Pharmaceutics, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil 3 Department of Pharmaceutics, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil 4 Department of Pharmaceutics, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil 5 Department of Pharmacy, Faculty of Biological and Health Sciences, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina, MG, Brazil
- Source: Nanomaterials: Evolution and Advancement towards Therapeutic Drug Delivery (Part II) , pp 1-56
- Publication Date: June 2021
- Language: English
Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Drug Delivery Applications, Page 1 of 1
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Lipid nanoparticles, such as solid lipid nanoparticles and nanostructured lipid carriers, are drug delivery systems in which solid lipids are dispersed in an aqueous phase stabilized by a surfactant layer. The great interest in these nanocarriers in the latest years is due to the biocompatible lipid matrix, associated with the potential for sustained drug release, and easy transposition to the industrial scale. Moreover, these lipid systems present the ability to prevent drug degradation, and to enhance cell uptake, usually increasing drug efficacy. This chapter will provide an overview of the recent literature on solid lipid nanoparticles and nanostructured lipid carriers for drug delivery applications. Thus, some background information on the origins, composition, characterization parameters and biological applications of these nanocarrier systems will be presented.
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