Organocatalytic α-hydroxylation or α- aminoxylation of Carbonyl Compounds
- Authors: Armando Talavera Aleman, Rosa E. del Río, Christine Thomassigny3, Christine Greck4
-
View Affiliations Hide Affiliations3 Universit de Versailles Saint-Quentin-en-Yvelines, ILV, UMR CNRS 8180, 45, Avenue des Etats-Unis, 78035Versailles, France. 4 Universit de Versailles Saint-Quentin-en-Yvelines, ILV, UMR CNRS 8180, 45, Avenue des Etats-Unis, 78035Versailles, France.
- Source: Advances in Organic Synthesis: Volume 10 , pp 1-40
- Publication Date: September 2018
- Language: English
Organocatalytic α-hydroxylation or α- aminoxylation of Carbonyl Compounds, Page 1 of 1
< Previous page | Next page > /docserver/preview/fulltext/9781681087436/chapter-1-1.gif
α-Hydroxylation or α-aminoxylation of carbonyl compounds in the presence of an organocatalyst has become a significant method for the creation of asymmetric C-O bonds. From the first studies with the classical proline-type or Cinchona-derived organocatalysts, methods have evolved to more efficient systems. Phase-transfer organocatalysts, flow chemistry, ionic liquids, electrochemistry or photo-oxidation permit the reaction with a large range of substrate. While originally aldehydes and ketones were used in these reactions, it is now possible to extend the scope to amides or dicarbonyl compounds such as β-keto ester and β-keto amide. The present review aims to present a general overview of the evolution of these systems.
-
From This Site
/content/books/9781681087436.chapter-1dcterms_subject,pub_keyword-contentType:Journal -contentType:Figure -contentType:Table -contentType:SupplementaryData105
