Theoretical Models of Hematopoietic Cell Dynamics Related to Bone Marrow Transplantation
- Authors: Radu Precup1, Delia Dima2, Ciprian Tomuleasa3, Marcel-Adrian Serban4, Lorand-Gabriel Parajdi5
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View Affiliations Hide Affiliations1 Department of Mathematics, BabeşBolyai University, Cluj Napoca, Romania. 2 Department of Hematology, Ion Chiricuţă Oncology Institute, Cluj-Napoca, Romania 3 Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania 4 Department of Mathematics, BabeşBolyai University, Cluj Napoca, Romania. 5 Department of Mathematics, BabeşBolyai University, Cluj Napoca, Romania.
- Source: Frontiers in Stem Cell and Regenerative Medicine Research: Volume 8 , pp 202-241
- Publication Date: August 2018
- Language: English
Theoretical Models of Hematopoietic Cell Dynamics Related to Bone Marrow Transplantation, Page 1 of 1
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This review article presents some mathematical models of hematopoietic cell dynamics related to bone marrow transplantation. Both allogeneic and autologous stem cell transplantations are considered. The models are expressed by threedimensional systems of ordinary differential equations whose variables stand for the abundances of healthy, leukemic and infused cells. Model parameters quantify the cellular processes of growth, cell death and sensibility to microenvironment, and cellcell interactions such as anti-host, anti-cancer and anti-graft effects. Numerical simulations and stability analysis of system equilibria are performed in order to conclude about effectiveness of transplantation procedures. In the case of allogeneic transplantation, the role of initial cell concentrations is highlighted and several therapeutic scenarios for correction of bad post-transplant evolution are suggested. The exposition is mainly based on authors' papers [3,72,75,78-80].
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