Unravelling Mesenchymal Stem Cell Signature in Regenerative Medicine
- Authors: Genni Desiato1, Morris Losurdo2, Chiara A. Elia3, Anna Saccomano4, Silvia Coco5
-
View Affiliations Hide Affiliations1 School of Medicine and Surgery, University of Milano Bicocca, Monza, Italy 2 School in Neuroscience, University of Milano Bicocca, Italy 3 IRCCS Humanitas, Rozzano, Italy 4 School of Medicine and Surgery, University of Milano Bicocca, Monza, Italy 5 School of Medicine and Surgery, University of Milano Bicocca, Monza, Italy.
- Source: Frontiers in Stem Cell and Regenerative Medicine Research: Volume 8 , pp 55-129
- Publication Date: August 2018
- Language: English
Unravelling Mesenchymal Stem Cell Signature in Regenerative Medicine, Page 1 of 1
< Previous page | Next page > /docserver/preview/fulltext/9781681085890/chapter-2-1.gif
Mesenchymal stromal/stem cells (MSCs) represent suitable candidates for regenerative medicine purposes given their ability to differentiate in several cellular lineages, to migrate to site of injury, to secrete soluble factors crucial for cell survival and proliferation, as well as to modulate immune response. Although the exact mechanisms of action are still under investigation, several MSC- based clinical trials developed for various diseases, including organ injuries, systemic diseases, chronic inflammatory and autoimmune pathologies are ongoing. Recently, the possibility of using less immunogenic and more specific MSC by-products (i.e. microvesicles and exosomes) to overcome MSC transplantation criticisms and side effects is currently under consideration.
-
From This Site
/content/books/9781681085890.chapter-2dcterms_subject,pub_keyword-contentType:Journal -contentType:Figure -contentType:Table -contentType:SupplementaryData105
