Oxidative and Nitrosative Stress, Immune Inflammation and Trptophan Catabolites in Driving Melatonergic Pathway Alterations in Depression: Treatment Implications
- Authors: George Anderson1, Michael Maes2
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View Affiliations Hide Affiliations1 CRC Scotland & London, Eccleston Square, London, UK 2 Department of Psychiatry, Deakin University, Geelon, Australia
- Source: The Search for Antidepressants - An Integrative View of Drug Discovery , pp 222-241
- Publication Date: July 2017
- Language: English
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In this chapter we review the interactions of oxidative and nitrosative stress (O&NS), immune-inflammation, tryptophan catabolites (TRYCATs) and suboptimal mitochondrial functioning in driving changes in the melatonergic pathways in major depressive disorder (MDD). We propose that such interactive biological processes provide a framework for the development of a number of novel pharmaceutical and nutriceutical treatment targets, with relevance to a classification of MDD that is based on biological underpinnings rather than on subjective phenomenology.
Hardbound ISBN:
9781681084749
Ebook ISBN:
9781681084732
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