Monoamine Oxidase-A: A Valid Target for the Management of Depression
- Authors: Bijo Mathew1, Jerad Suresh2
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View Affiliations Hide Affiliations1 Division of Drug Design and Medicinal Chemistry Research Lab, Department of Pharmaceutical Chemistry, Ahalia School of Pharmacy, Palakkad 678557, Kerala, India 2 Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai 600004, India
- Source: The Search for Antidepressants - An Integrative View of Drug Discovery , pp 126-134
- Publication Date: July 2017
- Language: English
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Monoamine oxidase enzyme has been developed as a valid target for the treatment of depression. The development of selective and reversible type of monoamine oxidase-A inhibitors still remains a challenge to medicinal chemists pursuing the research towards the search of innovative chemotypes for the management of depressive states. The present chapter focuses on the history of MAO-A inhibitors, structure and biochemistry of MAO-A. It also covers challenges involved in the drug development of MAO-A inhibitors.
Hardbound ISBN:
9781681084749
Ebook ISBN:
9781681084732
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