Genome Maintenance in Trypanosomatids
- Authors: Gonzalo Cabrera1, Viviane G. Silva2, Isabela C. Mendes3, Carlos R. Machado4, Richard McCulloch5
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View Affiliations Hide Affiliations1 Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile 2 Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil 3 Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil 4 Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil 5 The Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Sir Graeme Davis Building, 120 University Place, Glasgow, G12 8TA, UK
- Source: Molecular and Cellular Biology of Pathogenic Trypanosomatids , pp 195-260
- Publication Date: February 2017
- Language: English
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The genome is the source of life, providing the information needed to direct all aspects of organismal function. Propagation of life requires copying of the genome and faithful transmission from parent to offspring. Many challenges confront genome propagation, including ensuring the accurate and complete copying of the DNA, circumventing impediments to DNA replication, and maintaining genome integrity in the face of myriad insults and during periods of cellular quiescence. Just as importantly, the genome must be allowed to change, either incrementally through small mutations in sequence or by large-scale rearrangements. Such changes not only drive evolution, but can be integral components of an organisms life cycle. In this chapter we consider the rapidly growing body of knowledge on how the genomes of kinetoplastid parasites are maintained, by describing the range of genome repair and damage tolerance pathways that operate. We focus on Trypanosoma brucei, Trypanosoma cruzi and Leishmania, three important human and animal pathogens, but we believe the lessons learned from the study of genome maintenance in these genetically tractable parasites are applicable widely, not only to other parasites but throughout biology.
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