Aging and Inflammation
- Authors: Daipayan Banerjee1, Alexander A. Karakashian2, Mariana N. Nikolova Karakashian3
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View Affiliations Hide Affiliations1 Department of Physiology, University of Kentucky College of Medicine, Lexington, KY, USA 2 Department of Physiology, University of Kentucky College of Medicine, Lexington, KY, USA 3 Department of Physiology, University of Kentucky College of Medicine, Lexington, KY, USA
- Source: Basic Biology and Clinical Aspects of Inflammation , pp 106-137
- Publication Date: March 2016
- Language: English
Aging and Inflammation, Page 1 of 1
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Inflammaging is a term referring to the constitutive low-grade inflammation that underlies the process of aging. The causes of inflammaging stem from an upregulation of the innate and a decline in the adaptive immune systems and involve chronic induction of the production of inflammatory mediators, including cytokines, chemokines, and bioactive lipids. Damaged DNA and protein that accumulate in the cells of the aging organisms, oxidative stress, and changes in the function of adipose tissue are among the key culprits leading to the onset of inflammaging. Changes in cytokine signaling pathways at cellular levels also occur with aging, contributing to propagation of inflammation. The inflammaging is considered the main contributing factor to the development of various aging-associated diseases, including cancer, atherosclerosis, metabolic, and neurodegenerative diseases. At least in animal models, inflammaging is subdued by common anti-aging therapies like caloric restriction and resveratrol.
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