Effect of Microenvironment Modulation on Stem Cell Therapy for Peripheral Nerve Injury
- Authors: Sufang Liu1, Feng Tao2
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View Affiliations Hide Affiliations1 Department of Physiology, Zhengzhou University School of Medicine, Zhengzhou, Henan Province, China 2 Department of Biomedical Sciences, Texas A&M University Baylor College of Dentistry, 3302 Gaston Avenue, Dallas, Texas, USA
- Source: Frontiers in Stem Cell and Regenerative Medicine Research: Volume 2 , pp 190-224
- Publication Date: April 2016
- Language: English
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Previous studies have demonstrated that nerve damage results in rapid disruption of nerve function. Neural stem cells (NSCs) from spinal cord have been shown to promote peripheral nerve regeneration. However, the stem cell therapy still shows low efficiency in vivo and some miscommunications after nerve recovery. Our studies found that chemotactic factor stromal-cell derived factor 1α and hypoxia may improve the survival of the transplanted NSCs and their function. Here we discuss the effects of microenvironment on neural stem cell therapy for peripheral nerve injury and recent progresses in this research field.
Hardbound ISBN:
9781681081847
Ebook ISBN:
9781681081830
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