Differentiation Potential of Stem Cells into Ovarian Cells
- Authors: Derek Toms1,2, Paul W. Dyce3,4, Julang Li5
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View Affiliations Hide Affiliations1 Department of Animal Biosciences, University of Guelph, Guelph, Ontario, Canada 2 Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Alberta, Canada 3 Department of Animal Biosciences, University of Guelph, Guelph, Ontario, Canada 4 Department of Animal Sciences, Auburn University, Auburn, Alabama, USA 5 Department of Animal Biosciences, University of Guelph, Guelph, Ontario, Canada.
- Source: Frontiers in Stem Cell and Regenerative Medicine Research: Volume 2 , pp 116-156
- Publication Date: April 2016
- Language: English
Differentiation Potential of Stem Cells into Ovarian Cells, Page 1 of 1
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The following chapter outlines the current research status of studies exploring the generation of two essential ovarian cell types from stem cells: meiotic female germ cells from primordial germ cells to oocytes; and supporting somatic granulosa cells that are necessary for correct germ cell development and sex hormone production. Recent studies have reported the generation of both cell types in vitro and in vivo from a variety of sources, including somatic stem cells, induced pluripotent stem cells, and embryonic stem cells. While significant progress has been demonstrated, there are many areas that require further investigation. This review also discusses current research limitations and future prospects of this field within the context of regenerative medicine.
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