Stem Cells for Treatment of Articular Cartilage Defects and Osteoarthritis
- Authors: Shipin Zhang1, Jun Sheng Wong2, Fulya Ustunkan3, Wern Cui Chu4, Hee Hon Tan5, Eng Hin Lee6, Wei Seong Toh7,8
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View Affiliations Hide Affiliations1 Faculty of Dentistry, National University of Singapore, Singapore 2 Faculty of Dentistry, National University of Singapore, Singapore 3 Department of Orthopaedic Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 4 Faculty of Dentistry, National University of Singapore, Singapore 5 Faculty of Dentistry, National University of Singapore, Singapore 6 Department of Orthopaedic Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 7 Faculty of Dentistry, National University of Singapore, Singapore 8 Tissue Engineering Program, Life Sciences Institute, National University of Singapore, Singapore
- Source: Frontiers in Stem Cell and Regenerative Medicine Research: Volume 2 , pp 255-288
- Publication Date: April 2016
- Language: English
Stem Cells for Treatment of Articular Cartilage Defects and Osteoarthritis, Page 1 of 1
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Articular cartilage is prone to damage from sports injuries/aging, which often progresses to osteoarthritis, an inflammatory and degenerative joint disease characterized by degradation of the entire joint, leading to pain and disability. Current pharmaceutical and surgical interventions relieve pain and improve joint function, but the long-term results are not satisfactory. More recently, stem cell-based strategies that include direct intraarticular injection of mesenchymal stem cells and implantation of tissue-engineered cartilage grafts have been developed. This chapter will first review the cartilage structure, composition, and pathology, and then summarize the most recent advances in applying mesenchymal stem cells for treatment of cartilage defects and osteoarthritis.
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