Cancer Therapy May be Improved if Diet Contains Omega 3 Fatty Acids
- Authors: Johannes F. Fahrmann, Theodore R. Witte, W. Elaine Hardman3
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View Affiliations Hide Affiliations3 Department of Biochemistry and Microbiology, Translational Genomic Research Institute, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, United States
- Source: Cutting Edge Therapies for Cancer in the 21st Century , pp 387-424
- Publication Date: April 2014
- Language: English
Cancer Therapy May be Improved if Diet Contains Omega 3 Fatty Acids, Page 1 of 1
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Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (FAs) are essential fats that must be obtained from the diet. The typical western diet is heavily weighted towards n-6 FAs with little n-3 intake. Recently, numerous studies have suggested that arachidonic acid (AA), an n-6 FA, and its metabolites have a significant role in tumor promotion. Inversely, n-3 fatty acids have consistently been shown to slow the growth and increase the chemo-sensitivity of various malignancies in vitro and in vivo. Clinical studies utilizing n-3 as adjuvants to therapy have shown much promise. The purpose of this chapter is to provide an overview of n-3 and n-6 fatty acids and their application to cancer. In this chapter we will be focusing on 1) the metabolism of n-3 and n-6 FA, 2) the mechanisms of action and implications in cancer and 3) the application of n-3 as promising therapies for the treatment of cancer.
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