Tau-Induced Neurodegeneration in Alzheimer Disease and Related Tauopathies
- Authors: Alejandra del C. Alonso1, Bin Li2, Inge Grundke Iqbal3, Khalid Iqbal4
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View Affiliations Hide Affiliations1 Department of Biology and Center for Developmental Neuroscience and Developmental Disabilities, College of Staten Island, The City University of New York, Staten Island, NY 10314, USA 2 New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, 10314, USA 3 New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, 10314, USA 4 New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, 10314, USA
- Source: Advances in Alzheimer's Research Volume 1 , pp 234-259
- Publication Date: November 2013
- Language: English
Tau-Induced Neurodegeneration in Alzheimer Disease and Related Tauopathies, Page 1 of 1
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The accumulation of hyperphosphorylated tau is a common feature of several dementias. Tau is one of the brain microtubule-associated proteins. Here, we discuss tau's function in microtubule assembly and stabilization with regards to tau's interactions with other proteins, membranes, and DNA. We describe and analyze important posttranslational modifications: hyperphosphorylation, glycosylation, ubiquitination, glycation, polyamination, nitration, acetylation, methylation, and truncation. We discuss how these post-translational modifications can alter tau's biological functions and what is known about tau self-assembly, and we propose a mechanism of tau polymerization. We analyze the impact of natural mutations on tau that cause fronto-temporal dementia associated with chromosome 17 (FTDP-1 7). Finally, we consider whether tau accumulation or its conformational change is related to tau-induced neurodegeneration, and we propose a mechanism of neurodegeneration.
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