Polymer-Drug Conjugates
- Authors: Marcel Popa1, Constantin V. Uglea2
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View Affiliations Hide Affiliations1 “Gheorghe Asachi” Technical University of Iasi, Faculty of Chemical Engineering and Environmental Protection, Department of Natural and Synthetic Polymers, Prof. dr. docent Dimitrie Mangeron Str., no. 73, 700050, Iasi, Romania 2 “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Department of Medical Bioengineering, Universitatii Str., no. 16, 700115 Iasi, Romania
- Source: Polymeric Nanomedicines , pp 190-232
- Publication Date: May 2013
- Language: English
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In this chapter we describe a series of polymer-drug conjugates synthesized in the last years. Our attention have been focused on known macromolecular supports such as poly(ethylene glycol) and N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers, as well as the novel macromolecular supports recently used in the synthesis of polymer-drug conjugates poly(amino acid)s, polylactides, cyclodextrins, poly(β,L-malic acid), hyaluronan, and chitosan. This chapter also describes the novel strategies such as combination chemotherapy, photodynamic therapy (PDT) and polymer-directed enzyme prodrug therapy (PDEPT) are included.
Hardbound ISBN:
9781608056286
Ebook ISBN:
9781608054848
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