Biocatalysis in the Preparation of the Statin Side Chain
- Authors: Arto Liljeblad, Annukka Kallinen, Liisa T. Kanerva3
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View Affiliations Hide Affiliations3 Pharmacology, Drug Development and Therapeutics, Laboratory of Synthetic Drug Chemistry and Department of Chemistry, University of Turku, Lemminkisenkatu 5 C, FIN 20520, Turku, Finland, Finland
- Source: Advances in Organic Synthesis: Volume 3 , pp 195-236
- Publication Date: January 2013
- Language: English
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Statins used in the treatment of dyslipidemias are top-selling drugs in the world. Economical production of statins in industrial scale is challenging, because the side chain of statins is a 3,5-dihydroxyacid derivative consisting of two asymmetric centers. The most prominent methods for the preparation of the side chain are based on biocatalysis and surveyed in this review.
Hardbound ISBN:
9781608055876
Ebook ISBN:
9781608054688
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