Sialic Acid Biosynthesis in Vertebrates
- Authors: Anja K. Münster Kühnel1, Stephan Hinderlich2
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View Affiliations Hide Affiliations1 Institute for Cellular Chemistry, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany 2 Department of Life Sciences & Technology, Laboratory of Biochemistry Beuth, University of Applied Sciences Berlin, Seestrasse 64, 13347 Berlin, Germany
- Source: Sialobiology: Structure, Biosynthesis and Function. Sialic Acid Glycoconjugates in Health and Disease , pp 76-114
- Publication Date: January 2013
- Language: English
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Sialic acids (Sia) represent a family of nine-carbon keto-sugars with an unusual high structural diversity. However, all members are biosynthetic derivatives of either N-acetylneuraminic acid or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid. In this chapter, we describe the biosynthesis of these two Sia precursors in vertebrates with a focus on the characteristiscs of the involved enzymes. In addition, the activation of the sugars as well as the degradation is included. Furthermore, dieseases and mouse models associated to the Sia biosynthesis pathway as well as biomedical implications are addressed.
Hardbound ISBN:
9781608050673
Ebook ISBN:
9781608053865
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