Calcium Channel Blockers: Past and Future
- Authors: Corina Duda Seiman1, Speranta Avram2, Daniel Duda-Seiman3, Bogdan Bumbacila4, Florin Borcan5, Rodica Cinca6
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View Affiliations Hide Affiliations1 West University of Timisoara, Chemistry Department, 16th Pestalozzi Str., Timisoara, RO-300115, Romania 2 University Bucharest, Faculty of Biology, Anatomy, Animal Physiology and Biophysics Dept., 91-95th Spl. Independentei, Bucharest-076201, Romania 3 University of Medicine and Pharmacy Victor Babes Timisoara, Medical ambulatory Dept., Cardiovascular prevention, 49th C.D. Loga Bvd., RO-300020, Romania 4 University of Medicine and Pharmacy, Victor Babes Timisoara, Faculty of Pharmacy, Timisoara, RO-300041, Romania 5 University of Medicine and Pharmacy, Victor Babes Timisoara, Pharm. Chem. Dept., 2nd Eftimie Murgu Sq, Timisoara, RO-300041, Romania 6 University of Medicine and Pharmacy, Victor Babes Timisoara, Pharmacology Dept., 2nd Eftimie Murgu Sq, Timisoara, RO-300041, Romania
- Source: Recent Trends on QSAR in the Pharmaceutical Perceptions , pp 51-62
- Publication Date: June 2012
- Language: English
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Calcium is an essential element in living organism and one of the most important minerals in the development and maintenance of bones and teeth. Calcium channel blockers (CCBs) are chemical substances which affect the movement of the calcium ion, Ca<sup>2+</sup>, through its specific channels. It is well-known as an important clinical path the usage of calcium channel blockers in order to decrease blood pressure of patients with hypertension. There were identified three types of calcium channels: voltage-sensitive, receptor-operated and stretch-operated. </p><p> In history, the first concepts of QSAR appeared when Richet, Meyer and Overton studied the relation between water/lipid solubility and toxicity or narcosis and Fisher underlined the importance of the steric configuration of a compound in enzymatic processes. Nowadays, the efforts to improve the class of CCBs are ongoing. The design of new active molecules with an improved pharmacotoxicological profile than the already discovered compounds of its class represent a very important aspect in the new drug development.
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