oa Cerebral Ammonia Metabolism in Cirrhosis
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- Authors: Michael Sørensen1, Peter Ott2
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View Affiliations Hide Affiliations1 PET Centre and Department of Medicine V, Aarhus University Hospital, Aarhus, Denmark 2 PET Centre and Department of Medicine V, Aarhus University Hospital, Aarhus, Denmark
- Source: Functional Molecular Imaging In Hepatology , pp 153-159
- Publication Date: May 2012
- Language: English
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Ammonia is thought to play a significant role in the development of hepatic encephalopathy (HE) in patients with liver failure. Some of the key questions have been whether there is an abnormal permeability surface-area product across the blood-brain barrier (PSBBB) for ammonia in patients with cirrhosis and whether the cerebral metabolic rate of ammonia is altered. In this chapter, we discuss how functional molecular imaging using positron emission tomography (PET) can be utilized for in vivo studies of cerebral ammonia kinetics and what the studies so far have shown.
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9781608056774
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9781608052905
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