oa Brain Energy and Ammonia Metabolism

- Authors: Lasse K. Bak1, Arne Schousboe2, Helle S. Waagepetersen3
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View Affiliations Hide Affiliations1 Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark 2 Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark 3 Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
- Source: Functional Molecular Imaging In Hepatology , pp 129-144
- Publication Date: May 2012
- Language: English


Brain Energy and Ammonia Metabolism, Page 1 of 1
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Brain metabolism is in principle similar to the biochemical processes which take place in all cells and organs. However, specialization of the different cell types in the brain, i.e. neurons or glial cells, adds a complexity which differs from other organs. In this chapter, a detailed outline of the metabolic processes providing the basis for brain energy and ammonia metabolism is provided. It also contains information regarding the effects on energy metabolism of a dysfunctional ammonia homeostasis such as that related to hepatic encephalopathy (HE). Moreover, methodological tools by which these metabolic processes may be studied experimentally such as PET as well as tissue and cell preparations are reviewed.
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