Modulation of Photodynamic Therapy by β-Glucan
- By Dalia Akramienė1
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View Affiliations Hide Affiliations1 Institute of Physiology and Pharmacology, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviiaus 9, LT 44307 Kaunas, Lithuania.
- Source: Beta-Glucan, Structure, Chemistry and Specific Application , pp 112-130
- Publication Date: May 2013
- Language: English
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Photodynamic therapy (PDT) combines a drug or photosensitizer with a specific type of light to eradicate cancer cells. The cellular damage induced by PDT leads to activation of the DNA damage repair, which is an important factor for modulating tumor sensitivity to this treatment. β-Glucans bind complement receptor 3 on the effector cells, thereby activating them to kill tumor cells during PDT. Here, the hypothesis that adjuvant therapy with β-glucans would increase the efficacy of PDT resulting in pronounced necrosis of PDT-treated tumors and suppression of the DNA damage repair system is discussed.
Hardbound ISBN:
9781608053018
Ebook ISBN:
9781608052608
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