TNF and Cancer: Friends and/or Foes?
- Authors: Loris Bertazza1, Simone Mocellin2, Mark DeWitte3, Donato Nitti4
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View Affiliations Hide Affiliations1 Mocellin: Department of Oncological, Surgical & Gastroenterological Sciences, Section of Clinica Chirurgica 2, University of Padova, via Giustiniani 2, 35128, Padua, Italy 2 Mocellin: Department of Oncological, Surgical & Gastroenterological Sciences, Section of Clinica Chirurgica 2, University of Padova, via Giustiniani 2, 35128, Padua, Italy 3 Haematology/Oncology Clinical R&D CSL Ltd, 45 Poplar Road Parkville, VIC,3052, Australia 4 Mocellin: Department of Oncological, Surgical & Gastroenterological Sciences, Section of Clinica Chirurgica 2, University of Padova, via Giustiniani 2, 35128, Padua, Italy
- Source: The Inflammatory Milieu of Tumors: Cytokines and Chemokines that Affect Tumor Growth and Metastasis , pp 29-56
- Publication Date: June 2012
- Language: English
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Tumor Necrosis Factor (TNF) is a pleiotropic cytokine with a central role in immune homeostasis, inflammation and host defence. Depending on the cellular context, TNF can induce diverse effects such as necrosis, apoptosis, differentiation, angiogenesis, cell migration and immune cell activation. Accordingly, TNF is believed to play a significant role in tumor development and progression; on the other side, this cytokine has potent antineoplastic activity both in experimental and clinical models. In the present chapter we provide a particular insight in the biology of TNF, emphasizing its tumor-related features, and discuss the experimental and clinical evidence available in the current literature supporting anticancer as well as cancer-promoting effects. Recent findings that may provide new alternatives to further exploit the anticancer power of TNF are also discussed.
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