The Metastatic Microenvironment
- Authors: Sivan Izraely, Isaac P. Witz2
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View Affiliations Hide Affiliations2 Department of Cell Research and Immunology, George S. Wise, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
- Source: The Inflammatory Milieu of Tumors: Cytokines and Chemokines that Affect Tumor Growth and Metastasis , pp 3-13
- Publication Date: June 2012
- Language: English
The Metastatic Microenvironment, Page 1 of 1
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Tumor cells making up the primary tumor and those in metastatic lesions are genetically and phenotypically different. It is safe to assume that the phenotype and functions of non-tumor cells such as endothelial cells, fibroblasts or macrophages residing in the microenvironment of primary tumors differ from those of similar non-tumor cells residing in metastatic microenvironments. It is therefore to be expected that the patho-biologic consequences of interactions between tumor cells and the microenvironments of the primary tumor or of the metastatic lesions will also be different.
Tumor-microenvironment interactions should, thus, be studied in the context of the site. This short review summarizes state of the art with respect to interactions between the brain microenvironment with brain-metastasizing tumor cells.
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