Bentham Science Publishers

Frontiers in Clinical Drug Research - Anti-Allergy Agents is an exciting eBook series comprising a selection of updated review articles relevant to the recent development of pharmacological agents used for the treatment of allergies. The scope of the reviews includes clinical trials of anti-inflammatory and anti-allergic drugs, drug delivery strategies used to treat specific allergies (such as inflammation, asthma and dermatological allergies), lifestyle dependent modes of therapies and the immunological or metabolic mechanisms that are of interest to researchers as targets for new drugs.

The first volume of this series sheds light on new therapies that can be employed for allergic reactions in patients (both traditional and non-traditional therapies), nutrition based therapies and the use of substances such as omalizumab and adrenaline to counter inflammatory response and anaphylaxis in patients.

Frontiers in Clinical Drug Research - Anti-Allergy Agents will be of interest to immunologists and drug discovery researchers interested in anti-allergic drug therapy as the series provides relevant cutting edge reviews written by experts in this rapidly expanding field.

Frontiers in Clinical Drug Research - Anti-Allergy Agents is a book series comprising of a selection of updated review articles relevant to the recent development of pharmacological agents used for the treatment of allergies. The scope of the reviews includes clinical trials of anti-inflammatory and anti-allergic drugs, drug delivery strategies used to treat specific allergies (such as inflammation, asthma and dermatological allergies), lifestyle dependent modes of therapies and the immunological or metabolic mechanisms that are of interest to researchers as targets for new drugs.

The third volume of this series brings 5 reviews which cover the following topics: H1 receptor selectivity, chronic spontaneous urticaria therapy, smooth muscle cell Ca2+ signaling pathway targeting for asthma therapy, allergic rhinitis and endosomal toll-like receptors.

Frontiers in Clinical Drug Research - Anti-Allergy Agents will be of interest to immunologists and drug discovery researchers interested in anti-allergic drug therapy as the series provides relevant cutting edge reviews written by experts in this rapidly expanding field.

Frontiers in Clinical Drug Research - Anti-Cancer Agents should prove to be a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field. The chapters featured in each volume are written by leading experts in oncology and clinical pharmacology. The eBook series is essential reading for all scientists involved in clinical drug research who wish to keep abreast of rapid and important developments in the development of anti-cancer agents.

The contents of this volume include reviews on dendrimers for anti-cancer drug delivery, treatment methods for advanced cutaneous squamous cell carcinoma, targeting heat shock proteins for cancer treatment, Bayesian systems for optimizing treatment protocols in oncology and much more.

Frontiers in Clinical Drug Research - Anti-Cancer Agents is a book series intended for pharmaceutical scientists, postgraduate students and researchers seeking updated and critical information for developing clinical trials and devising research plans in anti-cancer research. Reviews in each volume are written by experts in medical oncology and clinical trials research and compile the latest information available on special topics of interest to oncology researchers.

The fourth volume of the book brings forth reviews on biomarkers and new drugs used for treating gastrointestinal cancer and breast cancer. The volume also covers the topics of adjuvant therapy, cancer nanodrugs and the role of adiponectin and dicycloplatin in cancer therapy.

Frontiers in Clinical Drug Research - Anti-Cancer Agents is a book series intended for pharmaceutical scientists, postgraduate students and researchers seeking updated and critical information for developing clinical trials and devising research plans in anti-cancer research. Reviews in each volume are written by experts in medical oncology and clinical trials research and compile the latest information available on special topics of interest to oncology and pharmaceutical chemistry researchers.

The sixth volume of the book features reviews on these topics:

· Immunomodulating Agents in The Treatment of Acute Myeloid Leukemia

· Potential Natural Products for Prostate Cancer Management

· Inhibition of Key Protein-Protein Interactions by Small Molecules for Cancer Drug Design

· Efficacy of Hepatic Arterial Infusion Chemotherapy (HAIC) For Advanced Hepatocellular Carcinoma

· Targeting Cancer Stem Cells: Implications in Health and Disease

Frontiers in Clinical Drug Research - Anti-Cancer Agents is a book series intended for pharmaceutical scientists, postgraduate students and researchers seeking updated and critical information for developing clinical trials and devising research plans in anti-cancer research. Reviews in each volume are written by experts in medical oncology and clinical trials research and compile the latest information available on special topics of interest to oncology and pharmaceutical chemistry researchers. The eighth volume of the book features reviews on these topics:

- Key data management elements in clinical trials for oncological therapeutics

- Prospects for therapeutic targeting of microRNAs in brain tumors

- Breast cancer vaccines: current status and future approach

- Desmocollin-3 and cancer

- MDM2-p53 antagonists under clinical evaluation: a promising cancer targeted therapy for cancer patients harbouring wild-type tp53

- Towards targeted therapy: anticancer agents targeting cell organelle mitochondria

- Anticancer therapeutic strategies in gliomas: chemotherapy, immunotherapy, and molecularly targeted therapy in adults

Frontiers in Clinical Drug Research – Anti Infectives is an eBook series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of infectious diseases. The scope of the eBook series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs employed in the treatment of infectious diseases. Reviews in this series also include research on multi drug resistance and pre-clinical / clinical findings on novel antibiotics, vaccines, antifungal agents and antitubercular agents.

Frontiers in Clinical Drug Research – Anti Infectives is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of anti infective drug discovery and epidemiology.

The first volume of this series features reviews that cover a variety of topics including:

-Bacteriophage research against gram positive bacteria

-Edible vaccines

-Novel antibiotics against gram negative bacteria

-Antimicrobial resistance among enteric pathogens

Frontiers in Clinical Drug Research – Anti Infectives (Volume 9) is a book series that provides updated reviews on the latest advancements in development of pharmaceutical agents for treating infectious diseases. The series covers various topics, including chemistry, pharmacology, molecular biology, and biochemistry of natural and synthetic drugs. Additionally, it addresses multi-drug resistance and pre-clinical/clinical findings on antibiotics, vaccines, antifungal agents, and antitubercular drugs. This series is an invaluable resource for pharmaceutical scientists and postgraduate students, offering critical information to support clinical trials and research in anti-infective drug discovery and epidemiology.

The ninth volume presents five in-depth reviews, with topics including mature drugs and antivirals for COVID-19, bacteriocins as potent anti-infective agents, therapeutic interventions targeting free radicals in viral diseases, and a detailed exploration of natural anti-infective agents.

The five reviews included in this volume are:

- The role of mature drugs in the COVID-19 era

- Antivirals to treat COVID-19

- Ribosomally synthesized bacteriocins as potent anti-infective agents

- Therapeutic interventions against free radicals in viral diseases

- A comprehensive overview of natural anti-infective agents

Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field of neurology.

Volume 10 of the series continues to present novel information about new and interesting approaches to treat common neurological disorders, with a focus on neurodegeneration and pain medicine. The volume presents 7 detailed reviews in total.

- Neurodegenerative disease: prevention and treatment through plant extracts therapy

- Emerging novel approaches and recent advances in Parkinson`s disease treatment and diagnosis

- Neurotrophic factors to combat neurodegeneration

- Neural bases of executive function in ADHD children as assessed using FNIRS

- Modulation of mesenchymal stem cells, glial cells and the immune system by oligodeoxynucleotides as a novel multi-target therapeutic approach against chronic pain

- Chronic pain: focus on anticonvulsants

- A review of the impact of testosterone on brain and aging-related decline in brain behavioural function

Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in neurology and allied disciplines.

The twelfth volume of this series features these reviews:

Chapter 1: Recent Drugs Tested in Clinical Trials for Alzheimer's and Parkinson's Diseases Treatment: Current Approaches in Tracking New Drugs

Chapter 2: Neurobiology of Placebo: Interpreting Its Evolutionary Origin, Meaning, Mechanisms, Monitoring, and Implications in Therapeutics

Chapter 3: Role of Gut Microbiota in Neuroinflammation and Neurological Disorders

Chapter 4: The Role of Age in Pediatric Tumors of the Central Nervous System

Chapter 5: Drug Repurposing in CNS and Clinical Trials: Recent Achievements and Perspectives Focusing on Epilepsy and Related Comorbidities

Chapter 6: Progress on the Development of Oxime Derivatives as a Potential Antidote for Organophosphorus Poisoning .

Frontiers in Clinical Drug Research - CNS and Neurological Disorders is an eBook series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the eBook series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field of neurology.

The third volume of this series features six chapters that cover a variety of topics including:

- the role of Potassium transport channels in neuroprotection against tetrahydroprotoberberines

- cannabinoids in cell therapy for CNS disorders

- AMPA Receptor Antagonists

- therapeutic intervention in polyglutamine ataxias

- nutritional therapies in neurology practice

Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the eBook series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field of neurology.

The fifth volume of this series features reviews that cover the following topics:

-drug treatment for spinal cord injury

-action tremors

-natural products for Alzheimer's disease treatment

-non pharmacological approaches towards pain management

-biosensors for detecting neurodegenerative diseases

-NMDA receptor targeting

-alkaloid antidepressants

Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field of neurology.

The seventh volume of this series features reviews that cover the following topics related to the treatment of neurodegenerative diseases, epilepsy and stroke:

- Fatty Acid Amides as a New Potential Therapeutic Agent in Multiple Sclerosis

- Epileptic Seizures Detection Based on Non-Linear Characteristics Coupled with Machine Learning Techniques

- Hampering Essential Tremor Neurodegeneration in Essential Tremor: Present and Future Directions

- The Potential Therapeutic Role of the Melatoninergic System in Treatment of Epilepsy and Comorbid Depression

- Modeling Neurodegenerative Diseases Using Transgenic Model of Drosophila

- Genetic Basis in Stroke Treatment: Targets of Potent Inhibitors

Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field of neurology.

The ninth volume of this series features reviews that cover the following topics related to the treatment of a different CNS disorders, related diseases and basic neuropharmacology research:

- Integrating imaging and microdialysis into systems neuropharmacology

- Depression heterogeneity and the potential of a transdiagnostic and dimensional approach to identify biologically relevant phenotypes

- CAR-T cells in brain tumors and autoimmune diseases – from basics to the clinic

- Revaluation of thyrotropin-releasing hormone and its mimetics as candidates for treating a wide range of neurological and psychiatric disorders

- Natural BACE1 inhibitors: promising drugs for the management of Alzheimer's disease

- The possibilities of safe lithium therapy in the treatment of neurological and psychoemotional disorders

- Pharmacotherapy of multiple sclerosis and treatment strategies

Among neurodegenerative diseases, those that lead to a state of dementia are the aim of several investigations. Dementia is a chronic disease the prevalence of which is increasing worldwide. The number of dementia patients in the world is approximately 50 million, and it is estimated that the number of patients will reach 131.5 million by 2050. This increase will be accompanied by a significant increase in medical expenditures and other expenses, especially for elderly patients. Therefore, the maintenance cost of dementia in the future is expected to be quite high. For this reason, several investigations aim, firstly, to describe the key mechanisms involved in the origin of dementia and, secondly, to establish preventive and therapeutic strategies in order to understand and mitigate this debilitating pathology.

This volume of Frontiers in Clinical Drug Research - Dementia explores the current comorbidities that cause cognitive impairment and the current management alternatives for clinical cases of dementia. The reviews contributed in these volume will provide readers with a current perspective on the subject. The topics covered in this volume include:

- Comorbidities inducing mild cognitive impairment - an evaluation of the risk caused by some pathological conditions

- Tau-targeted therapy in Alzheimer's disease - history and current state

- Emerging nanotherapeutic strategies in Alzheimer's disease

- Implication of dehydroepiandrosterone on dementia related to oxidative stress

- Polyphenol compounds as potential therapeutic agents in Alzheimer’s disease

The volume is a timely update on dementia treatment for clinical physicians, neurologists, gerontologists, pharmaceutical and medicinal chemistry researchers, and physiologists.

Frontiers in Clinical Drug Research – Diabetes and Obesity is an eBook series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of two metabolic diseases – diabetes and obesity. The scope of the eBook series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs affecting endocrine and metabolic processes linked with diabetes and obesity. Reviews in this series also include research on specific receptor targets and pre-clinical / clinical findings on novel pharmaceutical agents. Frontiers in Clinical Drug Research – Diabetes and Obesity is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of diabetes and obesity research.

The second volume of this series features 7 reviews presenting updates on hormones and several classes of drugs:

-Osteocalcin action in glucose metabolism

-Sodium-glucose co-transporter 2 (SGLT2) inhibitors

-Glucagon-like peptide-1 (GLP-1) mimetics

-Dipeptidyl peptidase 4 (DPP-4) inhibitors

-New drugs in clinical trial and commercial phases

Frontiers in Clinical Drug Research – Diabetes and Obesity is an eBook series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of two metabolic diseases – diabetes and obesity. The scope of the eBook series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs affecting endocrine and metabolic processes linked with diabetes and obesity. Reviews in this series also include research on specific receptor targets and pre-clinical / clinical findings on novel pharmaceutical agents. Frontiers in Clinical Drug Research – Diabetes and Obesity is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of diabetes and obesity research.

The fourth volume of this series features 7 chapters:

-Pharmacologic Obesity Treatment

-Interplay Between Bile Acid and GLP-1 Receptor Agonist Signaling Informs the Design of Drugs to Combat Obesity and its Metabolic Complications

-Sodium–Glucose Co-Transporters Inhibitors for Type 2 Diabetes Mellitus

-The Effects of Traditional Chinese Medicine on Inflammatory Cytokines in Diabetic Nephropathy

-Through the Perspective of Histology – The Alzheimer’s Disease Promotion by Obesity and Glucose Metabolism: Type 3 Diabetes

-Pharmacological Mechanism of PPARγ Ratio in Diabetes and Obesity

-Hydrogen Sulfide and Carbohydrate Metabolism

Frontiers in Clinical Drug Research – Diabetes and Obesity is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of two metabolic diseases – diabetes and obesity. The scope of the series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs affecting endocrine and metabolic processes linked with diabetes and obesity. Reviews in this series also include research on specific receptor targets and pre-clinical / clinical findings on novel pharmaceutical agents. Frontiers in Clinical Drug Research – Diabetes and Obesity is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of diabetes and obesity research.

The sixth volume of this series features 6 reviews which are informative guides to therapy and drug administration in diabetes and metabolic syndrome, for both the medical specialist and the pharmacologist.

- The failing heart in diabetes with special emphasis on prevention

- Flavonoids as prominent anti-diabetic agents

- Chemosensor in glucose monitoring, advances and challenges

- Synergistic drugs and polyherbal formulations for obesity: current status and future prospectives

- Urge for herbal anti-diabetic medicines towards clinical and therapeutic implications

- Curcuma longa as dietary supplement and diabetes mellitus: evidence from experimental studies

Frontiers in Clinical Drug Research – HIV is an eBook series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of acquired immune deficiency syndrome (AIDS) and other disorders associated with human immunodeficiency virus (HIV) infection. The scope of the eBook series covers a range of topics including the medicinal chemistry and pharmacology of natural and synthetic drugs employed in the treatment of AIDS (including HAART) and resulting complications, and the virology and immunological study of HIV and related viruses. Frontiers in Clinical Drug Research – HIV is a valuable resource for pharmaceutical scientists, clinicians and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in HIV/AIDS research.

The first volume of this series features 7 chapters that cover a variety of topics including:

-Antiretroviral drug development

-HIV-1 genomics

-HIV drug targets such as ribosomes and HIV Integrase

-HAART associated nephrotoxicity

Frontiers in Clinical Drug Research - HIV is an eBook series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of acquired immune deficiency syndrome (AIDS) and other disorders associated with human immunodeficiency virus (HIV) infection. The scope of the eBook series covers a range of topics including the medicinal chemistry and pharmacology of natural and synthetic drugs employed in the treatment of AIDS (including HAART) and resulting complications, and the virology and immunological study of HIV and related viruses. Frontiers in Clinical Drug Research - HIV is a valuable resource for pharmaceutical scientists, clinicians and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in HIV/AIDS research.

The third volume of this series features 5 chapters that cover a variety of topics including:

- Studies of HPV infections in HIV positive people

- Allosteric Integrase Inhibitors

- HAART

- Drugs targeting various types HIV-1 enzymes

Frontiers in Clinical Drug Research – HIV is a book series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of acquired immune deficiency syndrome (AIDS) and other disorders associated with human immunodeficiency virus (HIV) infection. The scope of the book series covers a range of topics including the medicinal chemistry and pharmacology of natural and synthetic drugs employed in the treatment of AIDS (including HAART) and resulting complications, and the virology and immunological study of HIV and related viruses. Frontiers in Clinical Drug Research – HIV is a valuable resource for pharmaceutical scientists, clinicians and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in HIV/AIDS research.

The fifth volume of this series features 5 chapters that cover these topics:

- Clinical Eradication of Latent HIV Reservoirs: Where Are We Now?

- HIV-1 Genotypic Drug Resistance Testing and Next-Generation Sequencing

- Current and Promising Multiclass Drug Regimens and Long-Acting Formulation Drugs in HIV Therapy

- Role of Nanotechnology in HIV Diagnosis and Prognosis

- Preventive and Therapeutic Features of Combination Therapy for HIV

Frontiers in Clinical Drug Research – Hematology is an eBook series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of hematological disorders. The scope of the eBook series covers a range of topics including medicinal chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs employed in the treatment of anemias, coagulopathies, vascular diseases and hematological malignancies. Reviews in this series also include research on specific antibody targets, therapeutic methods, genetic hemoglobinopathies and pre-clinical / clinical findings on novel pharmaceutical agents. Frontiers in Clinical Drug Research – Hematology is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of hematology, oncology and vascular pharmacology.

The second volume of this series features 5 chapters that cover a variety of topics including:

-Chronic myeloid leukemia

-Bispecific and multivalent antibodies

-Natural Killer cells therapy for bone marrow transplantation

-Nanoparticles in health and disease

-Monoclonal antibody therapy for lymphoma

Frontiers in Clinical Drug Research – Hematology is a book series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of hematological disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs employed in the treatment of anemias, coagulopathies, vascular diseases and hematological malignancies. Reviews in this series also include research on specific antibody targets, therapeutic methods, genetic hemoglobinopathies and pre-clinical / clinical findings on novel pharmaceutical agents. Frontiers in Clinical Drug Research – Hematology is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of hematology, oncology and vascular pharmacology.

The fourth volume of this series features 5 reviews:

-TRP Channels: Potential Therapeutic Targets in Blood Disorders

-Hypercoagulable States: Clinical Symptoms, Laboratory Markers and Management

-Advanced Applications of Gene Therapy in the Treatment of Hematologic Disorders

-Ferroptosis - Importance and Potential Effects in Hematological Malignancies

-Clinical Application of Liquid Biopsy in Solid Tumor HCC: Prognostic, Diagnostic and Therapy Monitoring Tool

Frontiers in Clinical Drug Research – Central Nervous System presents the latest research and clinical studies on the central nervous system (CNS). It covers a range of topics such as the development and pathophysiology of the brain and spinal cord, physiological sites of drug action in the CNS and clinical findings on drugs used to treat CNS defects due to injury or impaired development. In addition to clinical research on humans, the book also highlights other avenues of CNS medicine and research such as pain medicine, stem cell research, pharmacology, toxicology and translational models in animals.

The first volume of the series features chapters on the following topics:

-Nerve targets in pain medicine

-Spinal cord injury

-Research on neurotoxins targeting voltage gated ion channels

-G protein coupled receptor agonists and modulators

-Drug research on mediating hypoxia in developing white matter

Frontiers in Clinical Drug Research – Anti infectives is a book series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of infectious diseases. The scope of the book series covers a range of topics including the chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs employed in the treatment of infectious diseases. Reviews in this series also include research on multi drug resistance and pre-clinical / clinical findings on novel antibiotics, vaccines, antifungal agents and antitubercular agents. Frontiers in Clinical Drug Research – Anti infectives is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of anti infective drug discovery and epidemiology.

The sixth volume of this series features these interesting reviews:

- Direct-acting antiviral drugs for treatment of Hepatitis C virus infection

- Plant lattices as anti-infective compounds

- Antimicrobial materials and devices for biomedical applications

- Recent advances in the treatment of toxoplasmosis

- Antimicrobial immunoglobulin prophylaxis and therapy

- Targeting Magnesium Homeostasis as Potential Anti-Infective Strategy Against Mycobacteria

Frontiers in Computational Chemistry presents contemporary research on molecular modeling techniques used in drug discovery and the drug development process: computer aided molecular design, drug discovery and development, lead generation, lead optimization, database management, computer and molecular graphics, and the development of new computational methods or efficient algorithms for the simulation of chemical phenomena including analyses of biological activity.

The Second volume of this series features nine different articles covering topics such as antibacterial drug discovery, high throughput screening, computational biochemistry with deMon2k, lipid bilayer analysis and much more.

Frontiers in Computational Chemistry presents contemporary research on molecular modeling techniques used in drug discovery and the drug development process: computer aided molecular design, drug discovery and development, lead generation, lead optimization, database management, computer and molecular graphics, and the development of new computational methods or efficient algorithms for the simulation of chemical phenomena including analyses of biological activity.

The fourth volume of this series features four chapters covering natural lead compounds, computer aided drug discovery methods in Parkinson’s Disease therapy, studies of aminoacyl tRNA synthetase inhibition in bacteria, computational modeling of halogen bonds in biological systems and molecular classification of caffeine and its metabolites.

Frontiers in Computational Chemistry presents contemporary research on molecular modeling techniques used in drug discovery and the drug development process: computer aided molecular design, drug discovery and development, lead generation, lead optimization, database management, computer and molecular graphics, and the development of new computational methods or efficient algorithms for the simulation of chemical phenomena including analyses of biological activity.

The sixth volume of this series features these six different perspectives on the application of computational chemistry in rational drug design:

- Computer-aided molecular design in computational chemistry

- The role of ensemble conformational sampling using molecular docking and dynamics in drug discovery

- Molecular dynamics applied to discover antiviral agents

- Pharmacophore modeling approach in drug discovery against the tropical infectious disease malaria

- Advances in computational network pharmacology for Traditional Chinese Medicine (TCM) research

- Progress in electronic-structure based computational methods: from small molecules to large molecular systems of biological significance

Frontiers in Drug Design and Discovery is a book series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The book series should prove to be of interest to all the pharmaceutical scientists involved in research in drug design and discovery. Each volume is devoted to the major advances in drug design and discovery.

The book series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.

The book series is available in print, online and CD editions.

Frontiers in Drug Design and Discovery is a book series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists have contributed chapters focused on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. This book series should prove to be of interest to all pharmaceutical scientists who are involved in research in drug design and discovery and who wish to keep abreast of rapid and important developments in the field.

Volume 11 of this series brings together reviews covering immunotherapy of sepsis, new antimalarials, and the medicinal use of onions for respiratory diseases, among other topics.

Topics included in this volume are:

- Heme-oxygenase and autophagy connected as a cytoprotective mechanism: potential therapeutic target

- Development of recombinant therapeutic proteins in animal cells: Challenges and solutions

- Artemisinin Analogues as a Novel Class of Antimalarial Agents: Recent Developments, Current Scenario and Future Perspectives

- The effects of Allium cepa and their derivatives on respiratory diseases and the possible mechanisms of these effects

- Immunotherapy of Sepsis

Frontiers in Drug Design and Discovery is a book series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The book series should prove to be of interest to all the pharmaceutical scientists involved in research in drug design and discovery. Each volume is devoted to the major advances in drug design and discovery.

The book series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.

The book series is available in print, online and CD editions.

Frontiers in Drug Design and Discovery is a book series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The book series should prove to be of interest to all the pharmaceutical scientists involved in research in drug design and discovery. Each volume is devoted to the major advances in drug design and discovery.

The book series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.

The book series is available in print, online and CD editions.

Frontiers in Drug Design and Discovery is an eBook series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists have contributed chapters focused on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. This eBook series should prove to be of interest to all pharmaceutical scientists who are involved in research in drug design and discovery and who wish to keep abreast of rapid and important developments in the field.

The seventh volume of this series brings together seven reviews covering chemotherapeutic agents, antimicrobials and phytochemicals.

Some topics included in this volume are:

1. Metabolic pathways and chemotherapy drugs

2. Cardiotoxicity of cancer chemotherapy

3. Nanotherapeutics for infectious diseases

4. Natural sources of angiogenesis inhibitors

…and much more.

Frontiers in Drug Design and Discovery Volume 9 is a book series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists have contributed chapters focused on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. This book series should prove to be of interest to all pharmaceutical scientists who are involved in research in drug design and discovery and who wish to keep abreast of rapid and important developments in the field.

The ninth volume of this series brings together reviews covering topics related to the treatment of neoplasms, systems biology, respiratory diseases among others.

Topics included in this volume are:

-Prognostic biomarkers in prostate cancer

-Chemoresistance in cancer cells

-GPCRS in systems and synthetic biology

-Mechanisms of action of ribavirin in different diseases

-Carbon nanotubes and drug targets

-The role of phosphatase I inhibitors in Minkowski spaces

-Phosphodiesterase targeting for treating respiratory diseases

Perspectives in Lung Cancer compiles basic and advanced topics on lung cancer pathology and treatment in a single volume. Chapters introduce the reader to chest and lung anatomy followed by the biology of lung cancer. Subsequent chapters delve into diagnostic methods for lung cancer while progressing into treatment options. The book culminates into an explanation of the concept of the Lung Cancer Centre, which is a representation of the editors' vision for organizing a lung cancer treatment unit.

Key features:

*Organises key topics covering both standard and avante-garde topics related to lung cancer

*All contributions are presented by experts in lung cancer treatment

*Addresses basic biology of lung cancer

*Provides information about 3D surgical planning, a relatively new concept in the field of thoracic surgery

*Addresses the standard method of resection, VATS and Mini VATS

*Covers the role of radiation and systemic anti-cancer therapies in lung cancer treatment

*Provides a glimpse of modern methods such as image guided surgery and therapy, laser therapy, and photodynamic therapy

*Covers the role of palliative care for lung cancer

*Presents information about a visionary organization of a lung cancer unit and treatment centre.

The combination of carefully organised chapters covering a wide array of topics makes this reference an essential reference for healthcare professionals interested in acquiring a broad perspective on lung cancer treatment with the goal of improving patient outcomes.

Frontiers in Medicinal Chemistry is a book series devoted to reviews on research topics relevant to medicinal chemistry and allied disciplines. Frontiers in Medicinal Chemistry covers developments in rational drug design, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, chemoinformatics, and structure-activity relationships. This book series is essential for any medicinal chemist who wishes to be updated on the latest and the most important advances in the field.

This is the tenth volume of the series. The extensive volume brings 11 reviews on a variety of topics including anti-cancer drug therapeutics, food chemistry, toxicology and drug development strategies.

The list of topics in this volume includes:

Isoxazole derivatives as potential pharmacophore for new drug development

Contemporary trends in drug repurposing: identifying new targets for existing drugs

Pharmaceutical potential of pyrimidines as antiviral agents

Drugs and phytochemicals targeting cancer

Harnessing the neurological properties of indian brain health booster brahmi Carcinogenicity of hexavalent chromium and its effects

Medicinal plants: a future of modern medical system

Shikonin, a naphthaquinone of commercial importance: its biosynthesis and prospect for use as drugs Fast foods: chemical composition and implications for health Implications of DNA-acting agents as anticarcinogenic potential in breast cancer therapeutics

Aloe vera - a medicinal plant as potential therapeutic agents for liver cancer

Frontiers in Medicinal Chemistry is a book series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. Frontiers in Medicinal Chemistry covers all the areas of medicinal chemistry, including developments in rational drug design, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, chemoinformatics, and structure-activity relationships.

Medicinal chemistry as a discipline is rapidly maturing. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Frontiers in Medicinal Chemistry aims to contribute in a major way to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. This book series is essential for any medicinal chemist who wishes to be kept informed and up-to-date with the latest and the most important advances.

"Frontiers in Medicinal Chemistry" is an Ebook series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. "Frontiers in Medicinal Chemistry" covers all the areas of medicinal chemistry, including developments in rational drug design, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, chemoinformatics, and structure-activity relationships.

Medicinal chemistry as a discipline is rapidly maturing. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. "Frontiers in Medicinal Chemistry" aims to contribute in a major way to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. This Ebook series is essential for any medicinal chemist who wishes to be kept informed and up-to-date with the latest and the most important advances.

"Frontiers in Medicinal Chemistry" is an Ebook series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. "Frontiers in Medicinal Chemistry" covers all the areas of medicinal chemistry, including developments in rational drug design, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, chemoinformatics, and structure-activity relationships. Medicinal chemistry as a discipline is rapidly maturing. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. "Frontiers in Medicinal Chemistry" aims to contribute in a major way to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. This Ebook series is essential for any medicinal chemist who wishes to be kept informed and up-to-date with the latest and the most important advances.

Frontiers in Medicinal Chemistry is an E-book series devoted to reviews on research topics relevant to medicinal chemistry and allied disciplines. Frontiers in Medicinal Chemistry covers developments in rational drug design, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, chemoinformatics, and structure-activity relationships. This E-book series is essential for any medicinal chemist who wishes to be updated on the latest and the most important advances in the field.

This volume features reviews on the following topics:

• Purinergic receptors and pain

• Cytochrome c – cardiolipin interactions in cells

• Dipeptidyl peptidase-4 (CD26) functions and inhibition

• Peptides regulating angiogenesis

• Application of melanotropin ligands for the treatment of obesity and related disorders

• Targeted drugs in the field of nanomedicine

Biosensing technology is rapidly flourishing in recent years due to the advancement of bio-MEMS/NEMS. However, the booming development of biosensors has not been very well addressed to the unmet clinical needs. Advances in Biosensing Technology for Medical Diagnosis initiates a headway into the realm of cutting-edge diagnostic tools which are expected to become routine clinical practice. This book aims to broaden the readers' horizon and guide them in tailoring different biosensing techniques for specific diagnostic procedures.

Key Features:

- 12 chapters cover several aspects of biosensing technologies including working principles and clinical validations

- highlights the state-of-the-art biosensing technology developed in all fields

- provides information about specific applications of novel biosensors used in clinical diagnosis,

- provides step-by-step guidance of microfabrication for biosensors

- focuses on bridging the gap between the scientific and the clinical communities

- provides information about the diagnostic applications of biosensors for different diseases (including infectious diseases and neurodegenerative diseases).

- covers Information about unconventional nano/microfluidic biosensor systems

- features contributions from renowned experts in the field of biomedical engineering

Advances in Biosensing Technology for Medical Diagnosis serves as a reference for healthcare providers and biomedical engineers who are interesting in biosensing techniques in medicine. The information provided in this reference will also benefit healthcare policymakers who are interested in new technologies that can impact the delivery of diagnostic services in healthcare systems.

"Frontiers in Natural Product Chemistry" is an Ebook series devoted to publishing the latest and most important advances in natural product chemistry. The Ebook series covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds including coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussion of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of new methods are included. Chosen eminent scientists write contributions and each volume are devoted to major advances in natural product chemistry. Topics include the isolation, structure, biosynthesis, biological activity, and chemistry of the major groups of natural products such as alkaloids, terpenoids, steroids, aliphatic, aromatic and O-heterocyclic compounds, and other metabolites of plant, marine and microbial origins, developments in enzymology, nucleic acids, genetics, chemical ecology, primary and secondary metabolism, isolation and analytical techniques, and other areas which will be of general interest to all workers in the area. "Frontiers in Natural Product Chemistry" is essential for all scientists involved in natural product chemistry who wish to keep abreast of rapid and important developments in the field.

Frontiers in Natural Product Chemistry is a book series devoted to important advances in natural product chemistry. The series features volumes that cover all aspects of research in the chemistry and biochemistry of naturally occurring compounds, including research on natural substances derived from plants, microbes and animals. Reviews of structure elucidation, biological activity, organic and experimental synthesis of natural products as well as developments of new methods are also included in the series.

Volume 11 of the series brings together 5 reviews:

- Medicinal importance of turmeric (curcuma longa) and its natural products

- Novel natural compounds for hepatocellular carcinoma treatment

- Herbal drug substitution (abhava-pratinidhi dravya): a key to stopping economic adulteration of botanical ingredients

- Synthetic and natural agents as bacterial biofilm inhibitors

- Quercetin chemistry, structural modifications, SAR studies and therapeutic applications: an update

Frontiers in Natural Product Chemistry is a book series devoted to publishing monographs that highlight important advances in natural product chemistry. The series covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds including coverage of work on natural substances of land and sea and of plants, microbes and animals. Reviews of structure elucidation, biological activity, organic and experimental synthesis of natural products as well as developments of new methods are included.

The third volume of the series brings seven reviews covering natural products from marine plant sources, natural oligosaccharides, topical sesquiterpenes for pain treatment, biological activity of piperidinols and much more.

Frontiers in Natural Product Chemistry is a book series devoted to publishing monographs that highlight important advances in natural product chemistry. The series covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds, including research on natural substances derived from plants, microbes and animals. Reviews of structure elucidation, biological activity, organic and experimental synthesis of natural products as well as developments of new methods are also included in the series.

The fifth volume of the series brings six reviews covering these topics:

-Inhibition of monoamine oxidase (MAO) via green tea extracts

-Sesquiterpene lactone cynaropicrin as novel inhibitor of Bcr-Abl fusion oncogene expression

-Effects of dietary polyphenols on chronic diseases

-Overview of past and present developments towards biotechnological and molecular approaches to improve taxol production

-Cytotoxicity through molecular targets involved in apoptosis

-Health related enzyme inhibiting natural products from medicinal plants

Frontiers in Natural Product Chemistry is a book series devoted to publishing monographs that highlight important advances in natural product chemistry. The series covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds, including research on natural substances derived from plants, microbes and animals. Reviews of structure elucidation, biological activity, organic and experimental synthesis of natural products as well as developments of new methods are also included in the series.

Volume seven of the series brings seven reviews covering these topics:

- Plant-Derived Anticancer Compounds Used in Cancer Therapies

- Pradimicin and Benanomicin Antibiotics

- The Chemical Compositions of Bixa orellana and their Pharmacological Activities

- Overview of Phytochemistry and Pharmacology of Nilakanthi (Ajuga bracteosa Wall. ex Benth.)

- Tetracyclic benzocarbazoles and derivatives

- Chalcones as Antiinflammatory, Antidiabetic, and Antidepressant Agents

- Bioactive Steroids from Marine Organisms

Frontiers in Natural Product Chemistry is a book series devoted to publishing monographs that highlight important advances in natural product chemistry. The series covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds, including research on natural substances derived from plants, microbes and animals. Reviews of structure elucidation, biological activity, organic and experimental synthesis of natural products as well as developments of new methods are also included in the series.

Volume nine of the series brings together 7 reviews on a variety of natural products and sources along with a chapter on the basics of investigating antioxidant activity.

Propolis and its key chemical constituents: a promising natural product in therapeutic applications

Investigation of the effects of using omega-3 fatty acids on egg quality in functional egg production

Quercetin, a flavonoid with remarkable anticancer activity

Swertiamarin for the treatment of metabolic syndrome

Overview of traditional uses, phytochemistry and pharmacology of Peganum harmala l.

Investigation of measurement methods of antioxidant activity and involved mechanisms

Recent progress on natural and synthetic flavanone and its derivatives

Role of virgin coconut oil as a multiple health promoting functional oil

Frontiers in Protein and Peptide Sciences is a book series focused on leading-edge research on the structure, physical properties, and functions of proteins and peptides. Authors of contributions in this series have updated their work with new experimental data and references following their initial research. Each volume highlights a number of important topics in current research in the field of protein and peptide chemistry and molecular biology, including membrane proteins and their interactions with ligands, computational methods, and proteins in disease and biotechnology. The series is essential reading for protein chemists and researchers seeking the latest information about protein and peptide research.

Stem cell and regenerative medicine research is a hot area of research which promises to change the face of medicine as it will be practiced in the years to come. Challenges in 21st century to combat cancer, Alzheimer and related diseases may well be addressed employing stem cell therapies and tissue regeneration. The first volume of "Frontiers in Stem Cell and Regenerative Medicine Research" features reviews written by experts in key areas of stem cells and regenerative medicine. It summarizes the safety assessment of mesenchymal stem cells (MSC) in musculoskeletal implantation that can bridge the gap between translation from animals to humans. The most prevalent strategies to improve immune reconstitution after hematopoietic stem cell transplantation have also been focused upon. This is particularly important because chemotherapy and pre-transplant conditioning impairs thymic function.

The application of regenerative medicine for repair of damaged cornea and ocular has also been discussed. The emerging techniques for tissue engineering of functional corneal equivalents represent a new and fascinating way to treat corneal diseases. The area of recently used nanofibrous substrates, as an alternative tool for the expansion and differentiation of embryonic stem cells, has been included in this e-book. In future, such technologies could promote the use of hESC-derived cells for clinical applications successfully.

Stem cell and regenerative medicine research is an important area of clinical research which promises to change the face of medicine as it will be practiced in the years to come. Challenges in the 21st century to combat diseases such as cancer, Alzheimer's disease and retinal disorders, among others, may well be addressed employing stem cell therapies and tissue regeneration techniques. Frontiers in Stem Cell and Regenerative Medicine Research brings updates on multidisciplinary topics relevant to stem cell research and their application in regenerative medicine. The series is essential reading for researchers seeking updates in stem cell therapeutics and regenerative medicine.

Volume 11 includes 5 chapters on these topics:

- The use of embryology in clinical practice

- Molecular regulation and signaling transduction in human tissue development

- Cell differentiation on hydrogels and its application in regenerative medicine

- Stem cell therapy for sepsis

- Tumorigenicity assessments for stem cell-derived therapeutic products.