Bentham Science Publishers

Ever since the association between cancer and thrombosis was reported by Jean-Baptiste Bouillaud in the early 19th century, cancer-associated thrombosis has remained a challenging domain of cancer management. Thrombosis can at times be a lead to cancer diagnosis, while it often complicates medical situations as a coexisting disorder. In this handbook, the contributors have compiled comprehensive information on the subject to provide the reader a comprehensive review of current medical literature and guidelines for cancer-associated thrombosis.

Key Features

-clinically oriented text for application in healthcare settings

-current, evidence-based literature reviews and references

-includes guidelines on VTE prophylaxis, heparin effects and more

-includes information about special cases

Thrombosis in Cancer: A Medical Professional's Guide to Cancer Associated Thrombosis is an informative handbook for a broad range of readers in medicine, including generalists, residents, and graduate-level trainees.

Thyroid Ultrasonography and Fine Needle Aspiration Biopsy: A Practical Guide and Picture Atlas is a concise and visual reference for diagnostic ultrasonography and needle biopsy of the human thyroid gland. The book provides the reader essential information on how to 1) distinguish between normal and abnormal thyroid sonograms, 2) differentiate low suspicion for malignancy thyroid nodules from sonographically high suspicion nodules, 3) evaluate cervical lymph nodes and parathyroid glands, and 4) examine post-thyroidectomy patients with differentiated thyroid cancer. The reader is also introduced to the different thyroid nodule risk stratification systems in ultrasound imaging, when and how to perform thyroid fine needle aspiration biopsies, and the use of percutaneous ethanol injections for cystic thyroid nodules.

Key Features:

-11 chapters which begin with an introduction to thyroid ultrasound and progressively explain relevant diagnostic imaging and biopsy procedures for different thyroid diseases (including thyroid cancer and autoimmune diseases)

-multiple tables and figures which summarize and highlight important points

-more than 60 ultrasound images which illustrate various ultrasound signs and artefacts from patients

-a summary of the current standards for the evaluation and clinical management of thyroid nodules based on clinical practice guidelines

-a detailed list of references, abbreviations and symbols

The textbook is an essential reference for both practicing and training endocrine surgeons, endocrinologists, radiologists, cytopathologists, sonographers as well as any health care worker with an interest in managing thyroid and parathyroid diseases in their daily practice.

This e-book is a review on current understanding of the role of toll-like receptors (TLRs) in the lung in health and disease. Topics covered include 1) the expression, function and activation of TLRs during bacterial, viral and fungal infection of the airways, 2) the role of TLRs in the pathogenesis of genetic and environmental pulmonary disorders, and 3) TLR biology in lung transplantation. Each chapter highlights recent advances in a selected domain in lung disease research. This e-book serves as a comprehensive resource for both scientists and clinicians studying innate immune mechanisms in the lung and provides a single reference comprising both basic and specialized information.

The Topics in Anti-Cancer Research e-Book series covers important advances on both experimental (preclinical) and clinical cancer research in drug development.

Major developments in the fields of oncology are covered including mechanisms, tumor and stem cell biology, metastasis, tumor suppressors, cancer drug targets, drug clinical trials, cellular and molecular pathology, genomics and genetics, diagnostics, translational therapeutics, tumor immunology, and cancer prevention and epidemiology.

Topics in Anti-Cancer Research is an essential e-book series for oncologists, pharmaceutical scientists, clinicians, and to researchers in other related disciplines.

This is the second volume of the Patent eBook Series titled Topics in Anti-Cancer Research. The eBook includes updated chapters on topics relevant to contemporary cancer research published in the journal, Recent Patents on Anti-Cancer Drug Discovery.

This volume covers scientific and patented novel chemotherapeutic agents and drugs for metastatic castration-resistant prostate cancer and Ras/ Raf /MEK/ERK pathway, P1K, AKT and mTORC1/2 inhibitors, ATPase inhibitors for cancer therapy, and sphingomyelin biosynthesis which regulates cancer cell death and growth.

Other chapters also explain research on biochemical regulation i.e. cell cycle and energy metabolism, the role of genetic variations of FcγRs gamma receptors in monoclonal antibody based anti-cancer therapy and effectiveness of antiangiogenic therapy, endogenous angiogenesis inhibitors and anti-angiogenic drugs for the treatment of renal cell carcinoma, prevention of cancer by ribonucleotide reductase, anticancer activity of Erlotinib in glioblastoma and the mechanisms of action of nanodrugs and nano-sized camptothecin drugs in cancer chemotherapy. The volume also covers recent studies in the field of onconutrition. The broad range of topics covered in this second volume will be of immense interest to clinicians, scientists and R&D experts seeking new targets for the prevention of cancer, novel oncogenic biomarkers, and methods for cancer therapy.

This is the fourth volume of the eBook Series entitled Topics in Anti-Cancer Research. This volume covers new research as well as updated chapters on topics relevant to modern cancer research published in the journal Recent Patents on Anti-Cancer Drug Discovery.

Interesting diverse methods, new technologies and fast developing areas in the field of anti-cancer research are presented. The topics included in the present volume will be of great value to clinicians, scientists and R&D experts aiming to learn more about the latest developments and new alternatives for different types of cancer treatment.

The use of gold macro rods and ultrasound for cancer treatment with hyperthermia, obesity associated breast cancer, and the role of cytokines and chemokines pathways in studying cancer immunotherapy are discussed. The mechanism of antibody-drug and antibody-toxin conjugates alongwith clinical trials research, significance of transforming growth factor-beta and urokinase type plasminogen activator in tumorigenesis and reverstol studies in oncohematological disorders are also presented.

Other important areas covered include the discovery of novel compounds, drugs and chemotherapeutics in the treatment of lung cancer, biological functions of cell surface nucleolin in cancer, polymeric nanosystems and nanosystem applications used for anticancer drug therapy. Recent advances in development of new potent tubulin inhibitors and structures of molecular hybrids and their actions in different cell lines have also been discussed. All these studies focused are supported by recent associated patents

The topics covered in this fourth volume will be of immense interest for those researchers and scientists looking for new techniques, targets, drugs, compounds and drug delivery methods for various types of cancer and its control.

Topics in Anti-Cancer Research covers important advances on both experimental (preclinical) and clinical cancer research in drug development. The book series offers readers an insight into current and future therapeutic approaches for the prevention of different types of cancers, synthesizing new anti-cancer agents, new patented compounds, targets and agents for cancer therapy as well as recent molecular and gene therapy research. The comprehensive range of themes covered in each volume will be beneficial to clinicians, immunologists, and R&D experts looking for new anti-cancer targets and patents for the treatment of neoplasms, as well as varied approaches for cancer therapy.

Topics in Anti-Cancer Research covers new developments in the field of cancer. Novel

drugs as anticancer agents include natural and synthetic phenazines and other anti-cancer

compounds. It also encompasses the role of estrogen as endocrine disruptors and strategies

targeting cancer stem cells for the treatment of different types of cancers, including myeloma

and renal cell cancer.

The diversity of researches and topics published in this eBook Series will be valuable to

cancer researchers, clinicians, and cancer professionals aiming to develop novel anti-cancer

targets for the treatment of various cancers.

The topics covered in the eighth volume of this series are as follows:

-Novel Drugs for Multiple Myeloma

-Synthetic Estrogens are Endocrine Disruptors via Inhibition of AF1 Domain of ERs

-Recent Progress of Phenazines as Anticancer Agents

-Cancer Stem Cell Targeting for Anticancer Therapy: Strategies and Challenges

Topological geometrodynamics (TGD) is a modification of the theory of general relativity inspired by the problems related to the definition of inertial and gravitational energies in the earlier hypotheses. TGD is also a generalization of super string models. TGD brings forth an elegant theoretical projection of reality and builds upon the work by renowned scientists (Wheeler, Feynman, Penrose, Einstein, Josephson to name a few).

In TGD, Physical space-time planes are visualized as four-dimensional surfaces in a certain 8-dimensional space (H). The choice of H is fixed by symmetries of standard model and leads to a geometric mapping of known classical fields and elementary particle numbers. TGD differs from Einstein's geometrodynamics in the way space-time planes or ‘sheets' are lumped together. Extending the theory based on fusing number concepts implies a further generalisation of the space-time concept allowing the identification of space-time correlates of cognition and intentionality.

Additionally, zero energy ontology forces an extension of quantum measurement theory to a theory of consciousness and a hierarchy of phases is identified. Dark matter is thus predicted with far reaching implications for the understanding of consciousness and living systems. Therefore, it sets a solid foundation for modeling our universe in geometric terms.

Topological Geometrodynamics: An Overview explains basic and advanced concepts about TGD. The book covers introductory information and classical TGD concepts before delving into twistor-space theory, particle physics, infinite-dimensional spinor geometry, generalized number theory, Planck constants, and the applications of TGD theory in research. The book is a valuable guide to TDG theory for researchers and advanced graduates in theoretical physics and cosmology.

Towards A Unified Soil Mechanics Theory demonstrates mathematical models for saturated and unsaturated soils by defining the effective stress equation. Chapters present hydraulic models that simulate water distribution in pores. Parameters from these models are then used to demonstrate the use of an effective stress equation to understand the mechanics of soils that have different material constitutions.

Key Features:

-Sequentially explains soil modeling techniques for easy understanding

-Demonstrates the use of an effective stress equation based on data from porous-solid models.

-Explains how porous-solid models can simulate the soilwater retention curves of materials.

-Establishes an elastoplastic framework for the volumetric behavior of unsaturated soils that is used to simulate the phenomenon of collapse upon wetting and the behavior of expansive soils. -Explains the practical application of fully a coupled hydro-mechanical (critical state) soil model

-Includes scientific references for further reading The third edition includes additional information on retention curves in deforming curves, the application of a coupled hydro-mechanical model simulating undrained tests and the behavior of soils during static compaction, and the use of a porous-solid model to develop a fully analytical equation for the relative hydraulic conductivity of soils. The new chapters also cover the experimental parameters used to derive the models. This edition also updates material from previous editions, and adds new scientific references.

Towards A Unified Soil Mechanics Theory paves the way for a universal theory of soil mechanics that has a wide range of applications. The book is a valuable reference to civil engineers, geotechnical engineers, earth scientists and hydrologists interested in soil mechanics at both academic and professional levels.