Bentham Science Publishers

This e-book series is recommended for readers who are interested in or work with current theoretical and experimental research in medicinal chemistry, with an emphasis on computer aided-drug design and organic synthesis for therapeutic purposes. The e-book series encompasses the multidisciplinary field of medicinal chemistry which overlaps the knowledge of chemistry, physics, biochemistry, biology and pharmacology.

The second volume of the series contains the following topics:

-Current State-of-the-Art for Virtual Screening and Docking Methods

-Estimating Protein-Ligand Binding Affinity by NMR

-ADME/Tox Predictions in Drug Design

-Bioisosteric Replacements in Drug Design

New Findings from Natural Substances present the state-of-the-art and future prospects for the application of biomolecules in the pharmaceutical, agricultural, food and industrial sectors. The book presents eight reviews contributed by more than twenty experts on interesting natural substances, and plant sources, that serve as sources of natural remedies for a variety of ailments.

The reviews in the book cover the use of herbs like Heliotropium and Astragalus. Additional health benefits of extracts from essential oils, Caenorhabditis elegans, and olive oil, as well as the medicinal use of rosmarinic acid and hydrolates. The contributions highlight a range of pharmacological agents from natural sources that have anti-cancer, anti-inflammatory, cardioprotective and neuroprotective effects.

The contents are presented in a simple and organized style. The book will broaden the knowledge about biological products for a variety of readers - generalists, students and researchers, alike.

The book attempts to explain the main features of celestial mechanics using a new and unique technique. Its emphasis, in terms of applications, is on the Solar System, including its most peculiar properties (such as chaos, resonances, relativistic corrections, etc.). All results are derived in a reasonably transparent manner, so that anyone with a PC and a rudimentary knowledge of mathematics can readily verify them, and even extend them to explore new situations, if desired. The more mathematically oriented reader may also appreciate seeing quaternions as the basic algebraic tool of the new approach. Practicing astronomers may also be happy to learn that the method has eliminated the problem of zero divisors, and does not require using the rather controversial averaging principle. The book is intended for astronomers and mathematicians interested in mechanical motion.

Biomarkers are any measurable biochemical characteristics of an organism that reflect a particular physiological state. Biomarkers can take many different forms including particular proteins or peptides, antibodies, cell types, metabolites, hormones, enzyme levels, compounds related to genomics, etc. A biomarker can also be a substance introduced into a patient to assess the internal organ systems role.

In medicine, biomarkers considered as compounds isolated from serum, urine, or other fluids, can be used as an indicator of the presence or severity of a particular disease state. The use of biomarkers is becoming a fundamental practice in medicine, Biomarker research involves a significantly greater scope of laboratory medicine.

This monograph presents information on several types of biomarkers for general pathologies (preeclampsia, metabolic syndrome, iron metabolism, bone disease, liver function, renal function), cardiovascular pathology (including atrial fibrillation, peripheral artery disease, thrombotic disorders) and sepsis. Additional information on endocrine and salivary biomarkers is also presented.

New Trends in Biomarkers and Diseases: An Overview is an ideal reference for medical students, pathology trainees and clinical researchers seeking information on biomarkers in medicine.

Nucleic acid sequencing techniques have enabled researchers to determine the exact order of base pairs - and by extension, the information present - in the genome of living organisms. Consequently, our understanding of this information and its link to genetic expression at molecular and cellular levels has lead to rapid advances in biology, genetics, biotechnology and medicine. Next-Generation Sequencing and Sequence Data Analysis is a brief primer on DNA sequencing techniques and methods used to analyze sequence data. Readers will learn about recent concepts and methods in genomics such as sequence library preparation, cluster generation for PCR technologies, PED sequencing, genome assembly, exome sequencing, transcriptomics and more.

This book serves as a textbook for students undertaking courses in bioinformatics and laboratory methods in applied biology. General readers interested in learning about DNA sequencing techniques may also benefit from the simple format of information presented in the book.

Osteoarthritis is a chronic disease prevalent among the elderly. Its most prominent feature is the progressive destruction of articular cartilage which results in impaired joint motion, severe pain and ultimately disability. Its prevalence and its impact on daily life pose a significant public health problem. Today, a cure for osteoarthritis remains elusive and the management of the disease is largely palliative, focusing on the alleviation of symptoms. Current recommendations include a combination of pharmacological and non-pharmacological treatments. The term “non-pharmacological” includes physical therapy and rehabilitation, but also nutraceuticals. All guidelines on osteoarthritis management highlight the importance of weight loss and physical activity to improve the functional status of patients. A number of alternative therapies are also commonly suggested by physicians and physiotherapists in their daily practice. The efficacy of these therapies is not evidenced by strong clinical trials. This category includes education, information, electrotherapy, ultrasound, electromagnetic field, spa, hydrotherapy, acupuncture, etc. Non Pharmacological Therapies in the Management of Osteoarthritis reviews the clinical relevance of these therapies and the difficulties in conducting high quality trials assessing their efficacy. This e-book presents supportive scientific evidence for their efficacy and explains the mechanism of action of nutraceuticals targeting osteoarthritis. It also includes many example of exercises, mobilization and manipulation techniques directly useful for medical professionals.

With rapid progress being made in both theory and practical applications, Artificial Intelligence (AI) is transforming every aspect of life and leading the world towards a sustainable future. AI technology is fundamentally and radically affecting agriculture with a move towards smart systems. The outcome of this transition is improved efficiency, reduced environmental pollution, and enhanced productivity of crops.

Nondestructive Evaluation of Agro-products by Intelligent Sensing Techniques is a reference which provides readers timely updates in the progress of intelligent sensing techniques used for nondestructive evaluation of agro-products. Chapters, each contributed by experts in food safety and technology, describe existing and innovative techniques that could be or have been applied to agro-products quality and safety evaluation, processing, harvest, traceability, and so on. The book includes 11 individual chapters, with each chapter focusing on a specific aspect of intelligent sensing techniques applied in agriculture. Specifically, the first chapter introduces the reader to representative techniques and methods for nondestructive evaluation. Subsequent chapters present detailed information about the processing and quality evaluation of agro-products (e.g., fruits, and vegetables), food grading, food tracing, and the use of robots for harvesting specialty crops.

Key Features:

- 11 chapters, contributed by experts that cover basic and applied research in agriculture

- introduces readers to nondestructive evaluation techniques

- covers food quality evaluation processes

- covers food grading and traceability systems

- covers frontier topics that represent future trends (robots and UAVs used in agriculture)

- familiarizes the readers with several intelligent sensing technologies used in the agricultural sector (including machine vision, near-infrared spectroscopy, hyperspectral/multispectral imaging, bio-sensing, multi-technology fusion detection)

- provides bibliographic references for further reading

- gives applied examples on both common and specialty crops

This reference is intended as a source of updated information for consultants, students and academicians involved in agriculture, crops science and food biotechnology. Professionals involved in food safety and security planning and policymaking will also benefit from the information presented by the authors.

Novel Drug Delivery Systems - Part 1 provides a comprehensive exploration of controlled drug delivery systems (NDDS) and their impact on patient outcomes and therapeutic effectiveness. Covering key topics like the principles of controlled-release dosage forms, the role of polymers, and innovative techniques like microencapsulation and mucoadhesive systems, this book bridges foundational concepts with cutting-edge advancements. It also addresses specialized systems like gastroretentive, transdermal, and ocular drug delivery methods. Ideal for pharmaceutical professionals, students, and researchers, this book serves as a critical resource for understanding and developing advanced drug delivery technologies.

Key Features:

- Comprehensive introduction to controlled drug delivery concepts

- In-depth analysis of pharmacokinetics and polymers in NDDS

- Exploration of microencapsulation and mucoadhesive systems

- Insights into gastroretentive and transdermal drug delivery

- Overview of nanotechnology and implantable devices in drug delivery

- Coverage of the latest developments in injectables and ocular systems

INTRODUCTION:

Hypertension has become a major public health problem in the last few decades. High blood pressure is a serious risk factor for premature cardiovascular disease and end-organ damage including left-ventricular hypertrophy and congestive heart failure, which in turn increases the risk of cardiovascular morbidity and mortality.

While studies of hypertension have been performed worldwide in a variety of epidemiological settings such as diabetes, renal function, obesity and thyroid disorders, there is a need to identify appropriate treatment strategies

Novel Strategies and Approaches in Hypertension introduces the reader to different aspects of hypertension treatment (environmental and occupational factors and different clinical settings that can trigger the disease). The book also covers special topics related to the use of new diagnostic biomarkers for hypertension patients, as well as endocrine and nutrition-focused approaches to treat the condition.

This reference book will be useful for medical professionals involved in the management and care of patients affected with hypertension.

[Series Introduction]

Frontiers in Hypertension presents reference works, textbooks and monographs on both fundamental and advanced topics related to the pathophysiology, diagnosis and treatment of hypertension. The series is essential reading for medical students and professionals involved in hypertension and allied subspecialty treatment programs.

Numberama: Recreational Number Theory in the School System presents number patterns and mathematical formulas that can be taught to children in schools. The number theories and problems are reinforced by enjoyable games that children can play to enhance their learning in a fun-loving way. Key features of the book include:

• information about a number of well-known number theory problems such as Fibonaccci numbers, triangular numbers, perfect numbers, sums of squares, and Diophantine equations

• organized presentation based on skill level for easy understanding

• all basic mathematical operations for elementary school children

• a range of algebraic formulae for middle school students

• descriptions of positive feedback and testimonials where recreational number theory has been effective in schools and education programs

This book is a useful handbook for elementary and middle-school teachers, students, and parents who will be able to experience the inherent joys brought by teaching number theory to children in a recreational way.