Bentham Science Publishers

Neurodegenerative diseases are a complex heterogeneous group of diseases associated with site-specific premature and slow death of certain neuronal populations in brain and spinal cord tissues. For example, in Alzheimer disease, neuronal degeneration occurs in the nucleus basalis, whereas in Parkinson disease, neurons in the substantia nigra die. The most severely affected neurons in Huntington disease are striatal medium spiny neurons. The neuronal populations that are lost in neurodegenerative diseases modulate functions such as controlling movements, processing sensory information, memory, and making decisions. Although, the molecular mechanism of neurodegeneration remains unknown, but excitotoxicity, inflammation, and oxidative stress may contribute to neural cell demise independently or synergistically. The purpose of this E-book is to present readers with cutting edge and comprehensive information on molecular aspects of neurodegenerative diseases and neuroprotection in a manner that is useful not only to students and teachers, but also to researchers and physicians.

This volume of Frontiers in Heart Failure comprehensively covers the gap between clinical management of heart failure and advanced molecular imaging techniques (SPECT, PET, MRI etc.). These techniques provide valuable evidence to cardiologists for the evaluation and follow-up of heart failure patients. It brings forth established research data regarding the pathophysiology, clinical presentations and therapy of heart failure, in a balance between clinical items and molecular imaging modalities. Readers will also find additional chapters on hybrid cardiovascular imaging techniques as well as guidelines on imaging artifacts and radiation protection. This volume is a useful resource for radiologists, cardiologists, cardiac care nurses and medical physicists.

Cancer is one of the major causes of death worldwide. Despite hundreds of clinical trials currently in progress for cancer patients, the success rate is still very low. Understanding the molecular aspects of cancer development, the discovery of new molecular targets and rational drug design on this molecular basis should help in discovering early cancer biomarkers as well as novel therapeutic drugs.

This book describes various cancer topics on a molecular level and integrates information on the relationship between causes of cancer, cancer cell biology, metastasis, cancer prevention and drug design. This book should prove to be an extraordinary reference text for students, physicians and oncologists.

Today, treatment options for cancer patients typically include surgery, radiation therapy, immunotherapy, and chemotherapy. While these therapies have saved lives and reduced pain and suffering, cancer still takes millions of lives every year around the world. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early-stage diagnosis.

Molecular Targets and Cancer presents information about cancer diagnosis and therapy in a simple way. It covers several aspects of the topic with updated information on par with medical board levels. The book features contributions from experts and includes an overview of cancer from basic biology and pathology, classifications, surveillance, prevention, diagnosis, types of cancer, treatment and prognosis.

The second part of this book discusses specialized topics in clinical oncology which include the pathophysiology of various types of cancer, cancer screening, different types of cancer surgery, cancer stem cell-targeted immunotherapy, nanotechnology for precision medicine applications in cancer and cancer surveillance.

This comprehensive guide is a valuable resource for oncologists, researchers, and all medical professionals who work in cancer care and research.

Molecular and Physiological Insights into Plant Stress Tolerance and Applications in Agriculture is an edited volume that presents research on plant stress responses at both molecular and physiological levels. Key Features: - Emphasizes the morphological and physiological reactions of plants and the underlying molecular mechanisms when faced with stress from environmental or pathogenic factors. - Explores microbial dynamics within the plant rhizosphere and the application of plant growth-promoting bacteria as biofertilizers and endophytes as biocontrol agents to enhance crop growth and productivity for sustainable agriculture. - Systematically summarizes molecular mechanisms in plant stress tolerance and discusses the current applications of biotechnology, nanotechnology, and precision breeding to obtain stress-tolerant crops, contributing to climate-smart agriculture and global food security. - Includes contributions and references from multidisciplinary experts in plant stress physiology, plant molecular biology, plant biotechnology, agronomy, agriculture, nanotechnology, and environmental science. The content of the book is aimed at addressing UN SDG goals 2, 12, and 15 to achieve zero hunger and responsible consumption and production, and to sustainable use of terrestrial ecosystems, respectively. This comprehensive resource is suitable for researchers, students, teachers, agriculturists, and readers in plant science, and allied disciplines.

Marine ecosystems offer several benefits to human communities. To make sustainable use of these benefits, it is necessary to elucidate and conserve marine ecology, and strive to maintain a sustainable natural resource management program. For this reason, understanding the diversity and behavior of both macro-ecosystems and micro-ecosystems are crucial.

Monitoring Artificial Materials and Microbes in Marine Ecosystems explores microbial roles and their interaction with artificial materials in marine environments. After starting with simple topics for beginners, chapters explore methods to detect microorganisms in marine ecosystems and interactions of marine organisms with artificial materials. The sequential progression into advanced topics makes it easier to understand how to solve the reduction in marine-ecosystem viability caused by adverse events. Readers are provided with useful information for rehabilitating marine environments to make them sustainable for communities.

Topics are covered in 3 parts:

Part 1 is an introductory guide to marine ecosystems and environmental monitoring assessment. Readers are introduced to coral reef ecosystems, algal blooms and the role of environmental monitoring services in maintaining and restoring the quality of marine environments. This is followed by examples of sustainable marine environment assessment.

Part 2 provides information about methods to detect microorganisms (viruses and bacteria) and evaluate marine environments. This includes sample enrichment methods, electrochemical analysis, and single-cell imaging techniques. The highly sensitive and specific techniques presented in the book, are applicable in a wide variety of situations.

Part 3 is dedicated to interactions between artificial metallic materials and microorganisms in marine environments. Chapters in this section share results from several experiments conducted to separate microorganisms and biofilms from such environments.

This book is intended primarily for marine ecologists, microbiologists, environmental engineers, and engineers associated with industrial projects. This book is also useful as a text for undergraduate and graduate-level courses in marine biology, ecology, and microbiology.

Morphea and Related Disorders is a comprehensive reference on morphea. The book covers the subject in 20 chapters. The book starts with a detailed introduction and history of the morphea and its various classifications systems. Next, the book progresses into epidemiology, predisposing factors and pathogenic mechanisms, followed by histopathology for morphea diagnosis and a detailed review of clinical presentations.

Subsequent chapters cover associated diseases and extracutaneous manifestations, medical investigations, treatment guidelines and special topics (Idiopathic atrophoderma of Pasini and Pierini, Linear atrophoderma of Moulin, Parry-Romberg syndrome, Lichen sclerosus, pediatric morphea and eosinophilic fasciitis).

Key features:

-he most detailed reference book on morphea

-Easy and simple language for readers

-Chapter synopsis at the beginning of each chapter

-Learning points at the end of the chapter

-More than 100 high resolution colored photographs

-Information boxes and tables to enhance readability.

-Covers basic knowledge on morphea, including pathogenesis, clinical presentations, and classification

-Includes guidelines for professionals

-Includes chapters on special topics for advanced readers

Morphea and Related Disorders is the definitive reference book for medical students, residents, instructors, and physicians.

Mucosal Vaccine Delivery Systems: The Future of Immunization – Part I presents a pioneering exploration into the realm of mucosal vaccination, covering innovative delivery platforms, immunological mechanisms, and their diverse applications in human and veterinary medicine. This comprehensive volume examines the regulatory, economic, and technological landscapes shaping mucosal vaccine development, highlighting their pivotal role in combating infectious diseases, chronic ailments, and advancing cancer immunotherapy.

Key Features:

- Detailed insights into nasal, oral, pulmonary, gastrointestinal, and urogenital vaccination.

- Analysis of mucosal vaccines in pediatric and elderly healthcare.

- Exploration of adjuvants, bioprocessing challenges, and commercialization trends.

- Contributions from leading researchers in the field.

Multi-Objective Optimization in Theory and Practice is a simplified two-part approach to multi-objective optimization (MOO) problems.

This second part focuses on the use of metaheuristic algorithms in more challenging practical cases. The book includes ten chapters that cover several advanced MOO techniques. These include the determination of Pareto-optimal sets of solutions, metaheuristic algorithms, genetic search algorithms and evolution strategies, decomposition algorithms, hybridization of different metaheuristics, and many-objective (more than three objectives) optimization and parallel computation. The final section of the book presents information about the design and types of fifty test problems for which the Pareto-optimal front is approximated. For each of them, the package NSGA-II is used to approximate the Pareto-optimal front.

It is an essential handbook for students and teachers involved in advanced optimization courses in engineering, information science and mathematics degree programs.

This volume describes the advanced research on the behavior of electrons in ionized atoms and molecules. Readers will learn about relevant techniques used and experimental results for different electron and molecular theories. The information presented in the book is useful for scholars and researchers involved in nuclear and atomic physics programs. Topics covered in the volume include:

-Ionization experiments

-Kinetic energy studies of photoexcited carbon dichloride and tetrachloride molecules

-Selective excision of biomolecules in electron transfer experiments

-Particle and antiparticle collisions with rare gases

-Multiple scattering in electron Rutherford scattering spectroscopy

-Four-body effects in the 6He58 +58Ni scattering

-Twin atoms from doubly excited states of the hydrogen molecule