Bentham Science Publishers

Advances in Anticancer Agents in Medicinal Chemistry is an exciting eBook series comprising a selection of updated articles previously published in the peer-reviewed journal Anti-Cancer Agents in Medicinal Chemistry. The first volume gathers reviews of many classes of drugs of contemporary interest for cancer therapy and is devoted to small molecules inhibitors of various proteins involved in cancer development such as Casein kinase 2 (CK2), Protein kinase B (PKB), mTOR, Hsp90, P-glycoprotein (P-gp), Kinesin spindle protein (KSP), Cyclooxygenase 2 (COX-2), Histone deacetylase enzymes (HDACs) and Topoisomerase I.

Advances in Anticancer Agents in Medicinal Chemistry will be of particular interest to readers interested in anti cancer drug therapy as the series provides additional value to scientific research by entailing an approach of bringing relevant reviews up-to-date and thus more valuable for reference purposes.

More than 4 decades have passed since the birth of the first in vitro fertilized baby in 1978. The use of assisted reproductive technology (ART) to overcome infertility has increased steadily with the simultaneous increase in the number of fertility centers in every part of the world. Access to infertility clinics is playing an important role in the treatment of different forms of infertility (like tubal disease, ovarian aging, or ovarian dysfunction).

This book captures the state of current and recent advances in assisted reproduction technology in humans and livestock in an easy and comprehensive way for non-experts and learners. 10 chapters cover the biology of reproduction, and male ART methods (sperm retrieval and freezing) and female ART methods (oocyte activation, and cryopreservation), and finally embryo ARTs (assisted hatching and cloning techniques) with simple definitions and explanations. Tips to overcome problems are also presented where appropriate along with references for further reading.

This book is a simple primer for students who are involved in courses in embryology or reproductive technologies as part of programs in biology, biotechnology, medicine, and physiology.

Bioinformatics, and by extension omic sciences – the collective disciplines that are dependent on the use of extensive datasets of biological information – present a challenge of data management for researchers all over the world. Big data collected as part of research projects and experiments can be complex, with several kinds of variables involved. Coupled with continuously changing bioinformatics and information technology tools, there is a need to bring a multidisciplinary approach into these fields.

Advances in Bioinformatics, Biostatistics and Omic Sciences attempts to realize an integrated approach between all omic sciences, exploring innovative bioinformatics and biostatistical methodologies which enable researchers to unveil hidden sides of biological phenomena.

This volume presents reviews on the following topics which give a glimpse of recent advances in the field:

- New Integrated Mitochondrial DNA Bioinformatics Pipeline to Improve Quality Assessment of Putative Pathogenic Variants from NGS Experiments

- Variant Calling on RNA Sequencing Data: State of Art and Future Perspectives

- An innovative Gene Prioritization Pipeline for WES analyses

- New Integrated Differential Expression Approach for RNA-Seq Data Analysis

- Innovations in Data Visualization for Straightforward Interpretation of Nucleic Acid Omics Outcomes

This volume serves as a guide for graduate students in bioinformatics as well as researchers planning new projects as a part of their professional and academic activities.

The first volume of this Ebook series brings together the most recent advances from leading experts in the burgeoning field of biotechnology. This comprehensive text adopts a multidisciplinary approach and covers agricultural biotechnology, industrial and environmental biotechnology, pharmaceutical sciences and drug developments from plant sources, biochemical and molecular studies on gene expression, forestry, genetic engineering, gene delivery approaches, plant tissue culture and biochemical techniques/methods/protocols involved in different areas of plant biotechnology. This Ebook should prove to be a valuable resource for plant biotechnologists, plant biologists, biochemists, molecular biologists, pharmacologists, and pharmacists; agronomists, plant breeders, and geneticists; ethnobotanists, ecologists, and conservationists; medical practitioners and nutritionists; research investigators in industry, federal laboratories, and universities; and students and teachers in the biological and biomedical sciences at undergraduate and postgraduate levels.

Advances in Cancer Drug Targets is an e-book series that brings together recent expert reviews published on the subject with a focus on strategies for synthesizing and isolating organic compounds and elucidating the structure and nature of DNA.

The reviews presented in this series are written by experts in pharmaceutical sciences and molecular biology. These reviews have been carefully selected to present development of new approaches to anti-cancer therapy and anti-cancer drug development.

The contents of this book include chapters on heat shock protein 90, spindle assembly checkpoint, ErbB receptors, anti-tumor effects of bisphosphonates, biomarkers for risk assessment and prevention of breast cancer, fibrates action in Daunorubicin chemical reaction and many more.

The reference work serves to give readers a brief yet comprehensive glance at current theory and practice behind employing chemical compounds for tackling tumor suppression, DNA site specific drug targeting and the inhibition of enzymes involved in growth control pathways. This e-book volume will be of special interest to molecular biologists and pharmaceutical scientists.

Nanotheranostics is a recent medical field which integrates diagnostic imaging protocols and therapeutic functions to monitor real time drug release in the body and distribution to the target site. The combined processes allow technicians to observe the effectiveness of a specifically designed drug candidate and predict its possible side effects. All these features help clinicians in optimizing treatment options for cancer and other diseases for the individual patient. Current research is tailored to individual therapy because each drug may display a variety of responses depending on variations in an individual’s genetics and subsequently, their clinical biochemistry. Many tumors are still challenging for therapists in terms of available treatment and nanotheranostic strategies may help them to combat cancer more efficiently.

Advances in Cancer Nanotheranostics for Experimental and Personalized Medicine presents information about current theranostic technologies in use at clinics and recent research on nanotheranostic applications, with a focus on cancer treatment. Information is presented in seven organized chapters that cover the basics of cancer nanotheranostics, tumor microenvironmental factors, gene therapy and gene delivery concepts, and the combined application of diagnostic imaging with cancer chemotherapy. A chapter focusing on the role of non-coding MRNAs in breast cancer carcinogenesis is also included, giving readers a glimpse of the complexities in the molecular biology of cancer which drive the need for new theranostic technologies. The book is of interest to medical professionals (including oncologists and specialists in internal medicine), diagnostic imaging technicians, and researchers in the fields of pharmacology, molecular biology and nuclear medicine.

Classical field theory is employed by physicists to describe a wide variety of physical phenomena. These include electromagnetism, fluid dynamics, gravitation and quantum mechanics. The central entity of field theory is the field which is usually a multi component function of space and time. These multi component functions are usually grouped together as vector fields as in the case in electromagnetic theory and fluid dynamics, in other cases they are grouped as tensors as in theories of gravitation and yet in other cases they are grouped as complex functions as in the case of quantum mechanics. In order to know the value of the field one needs to solve a set of coupled partial differential equations with given boundary and initial conditions.

The book covers a selection of recent advances in classical field theory involving electromagnetism, fluid dynamics, gravitation and quantum mechanics.

Advances in Classical Field Theory will benefit readers by saving them the effort to read through numerous journal articles which would be needed to obtain a coherent picture of classical field theory otherwise. This eBook is unique in its aim and scope and is not similar to any existing publication.

This reference is an accessible update on combustion synthesis and the chemical technology for synthesizing composite materials. Nine chapters offer an overview of the subject with recent references, giving the reader an informed perspective.

The book starts with an introduction to thermodynamic models used in combustion synthesis. Subsequent chapters explain the application of combustion synthesis to manufacture different materials such as nanostructured non-ferrous alloys, ceramic powders, functionally graded materials, boron carbide-based superhard materials, shape memory alloys, biomaterials, high-entropy alloys and rare earth phosphates.

The range of topics makes this book a useful guide for students, scientists and industrial professionals in the field of chemical engineering, metallurgy and materials science.

Advances in Diagnostics and Immunotherapeutics for Neurodegenerative Diseases delves into the intricate mechanisms underlying neurodegenerative disorders and highlights cutting-edge diagnostic methods and innovative immunotherapeutic strategies. This comprehensive book addresses several key themes crucial to understanding and combating these debilitating conditions with an updated understanding of neurodegenerative disorders and a review of the latest advancements in diagnostic and treatment strategies.

Key Themes

Neuroinflammation: examines the complex molecular pathways involved in neuroinflammatory responses and their impact on disease dynamics.

Gut-Brain Axis: A thorough discussion on the relationship between the gut microbiome and neurodegenerative processes is presented.

Advanced Diagnostics: A state-of-the-art review of diagnostic techniques provides updates on advanced neuroimaging modalities, cerebrospinal fluid biomarker analysis, and genetic testing.

Epigenetic Regulation of Microglia: Covers the emerging field of epigenetic modifications and their role in modulating microglial activation and function.

Immunotherapeutics: Learn about the potential of monoclonal antibodies, immune modulators, and repurposed drug therapies in slowing disease progression and improving patient outcomes.

This book serves as a valuable resource for researchers, clinicians, and students in the fields of molecular biology, neuroimmunology, and clinical neurology.

This series provides information on the nature of dyes, their harmful effects, and dye degrading techniques. The second volume focuses on sophisticated oxidation methods for dye degradation. The information on target-oriented dye mitigation is intended to give readers a better understanding of the dye degradation process to sustain a healthy environment. Chapters present referenced information and highlight novel industry breakthroughs.

Key topics:

The Fenton process for dye removal

MOF-based and graphene oxide photocatalysts for dye degradation

Novel photocatalysts active in visible light and IR spectra

Photocatalytic degradation of transition metal dichalcogenides

Environment friendly synthesis of photocatalysts for dye degradation

Metal oxide Nanomaterials for dye degradation

This volume is a comprehensive singular resource on photocatalytic dye degradation for researchers, apprentices and learners in chemistry and chemical engineering courses. It also serves as a reference for industry professionals who work with chemical dyes (for example in textile and plastic industries) and are engaged in the critical field of environmental remediation.