Bentham Science Publishers

Recent advances in the fields of genomics and bioinformatics have made it increasingly clear that genetic sequence alone cannot explain how the genome regulates the development and function of complex multicellular organisms both in health and disease. This inference has led to the expansion of epigenetics as a discipline. Epigenetics refers to the way in which the environment in the wide sense participates in the regulation of gene expression. Several studies show that the well-known beneficial role of a healthy lifestyle over a number of pathologies or as a pre-emptive therapy is at least in part exerted through epigenetic mechanisms, thus giving rise to a new paradigm of preventive medicine based on the concept of genetic plasticity. In Epigenetics of Lifestyle, several contributors provide a comprehensive view of how various facets of lifestyle, including nutrition, exercise, stress, addiction or social interactions, affect chromatin (the combination of DNA and proteins that make up the contents of a cell nucleus) - resulting in profound and long-lasting changes in gene function. In summary, Epigenetics of Lifestyle is a fresh approach towards epigenetics and presents the reader with significant research findings in epigenetics and lifestyle studies. This volume is a simplified source of information for both undergraduate and working professionals interested in lifestyle medicine and life sciences in general.

The development of new erythropoietic stimulating agents (ESAs) has significantly increased in recent years. Researchers are focused on different and interesting concepts, namely, methods to increase half-life of erythropoietin (EPO), finding different routes of administration and new ESA or modified EPO molecules. Scientific literature presents evidence that EPO has other effects beyond erythropoietic stimulation. These pleiotropic effects of EPO appear to result from the existence of two different EPO receptors (EPOR) with different affinities for EPO. The discovery of new EPO actions beyond the hematopoietic system has opened a new field of investigation with these agents. Several molecules have been developed to present the protective action, without the activation of the hematopoietic system. These agents can be potentially used in several diseases of the brain/central and peripheral nervous system, eye, heart and kidney.

This volume of Frontiers in Drug Discovery includes a revision of articles on erythropoiesis and EPO gene regulation, microRNAs and their potential contribution to the development of new therapeutic strategies, animal models for studying kidney disease-associated anemia as well as benefits/risks of ESA therapy. The biological effects of new ESA molecules, heparin-binding erythropoietin and of pHBSP, and the potential applications of ESA, are also elicited in this volume.

This volume is, therefore, a useful reference for medicinal chemists and hematologists interested in drug development and medicine related to ESAs.

This handbook covers some primary instruments-based techniques used in modern biological science and medical research programs. Key features of the book include introductory notes for each topic, a systematic presentation of relevant methods, and troubleshooting guides for practical settings.

Topics covered in part 2 include:

· Fourier transform mid-infrared (FT-MIR) spectroscopy

· High performance liquid chromatography (HPLC)

· Raman spectroscopy

· Circular dichroism (CD) spectroscopy

· Transmission electron microscopy (TEM)

· Scanning electron microscopy (SEM)

· SEM-EDX and its applications in plant science

This book is a simple, useful handbook for students and teachers involved in graduate courses in life sciences and medicine. Readers will learn about the basics of featured techniques, the relevant applications and the established protocols.

This volume bridges scientific research with applied horticultural practices by examining the taxonomy, cultivation, ecological significance and conservation of ornamental and medicinal plants such as Fritillaria, Gladiolus, and Saffron.

This book explores environmental requirements and sustainable cultivation methods by covering topics from plant morphology and classification to seed and vegetative propagation techniques-including tissue culture. Chapters also highlight the ethnobotanical value of these species and the challenges posed by habitat loss and overharvesting, offering practical conservation strategies to mitigate human impact.

Key features:

Details morphological and taxonomic insights

Presents propagation techniques including advanced tissue culture

Discusses soil, climate, and ecological needs for optimal cultivation

Highlights traditional medicinal and ornamental applications

Emphasizes conservation strategies for protecting wild populations

This handbook presents information on different cell culture assays which can be used to perform experimental analysis. Readers are introduced to the basics of in vitro cell cultures followed by a comparative analysis of different experimental protocols designed to detect cellular processes (such as apoptosis, protein-protein interactions, cytotoxicity, gene transfer). Chapters present information on the basics of specific experimental techniques as well as the advantages and disadvantages of the presented methods. Students and scholars who require an understanding of the basic fundamentals of cellular assays.

Stephen Hawking, present occupant of the Lucasian Chair at Cambridge University, is today one of the best known theoretical cosmologists in the world. His important contributions, in collaboration with Roger Penrose, to the physics of black holes are well known, but this does not make comparable to those of Albert Einstein, as some times is affirmed in the mainstream media. In this book, Hawking´s work as presented at the Vatican Study Week on Astrophysical Cosmology (1981), his bestseller "A Brief History of Time" (1988), his lecture on "Gödel and the end of physics" (2002), and "The Grand Design"(2010) are briefly examined. In them many philosophical questions are raised but no rigorous answers are provided. In the second half of the book, chapters on the origin of science in the Christian West, the post-Renaissance scientific revolution, the true pioneers of modern physics put contemporary cosmology in a proper perspective. The authors conclude that contemporary observational data are compatible with a finite, open and contingent universe, rather than with "everything coming out of nothing". This book puts in a proper historical perspective, contrary to Hawking’s, that the universe is intelligible as attested by the monumental fact of modern science, and, therefore, that it is contingent, and therefore created. Very often, contemporary theoretical cosmologists ignore the crucial contributions made in Medieval Europe to the birth of modern physics. This book intends to bridge the gap in accessible language for the non specialist.

This book details all the intricacies and essential knowledge involved in the research and development of the Coronil Kit - a combination of 3 ayurvedic medications for the common cold. It informs the reader about the huge potential of herbal drugs in fighting against any type of disease through evidence-based data from clinical trials and experiments. The book elaborates how current scientific techniques can be applied to understand the healing capacities of plants at their molecular level and thus utilize their different combinations to treat diseases by targeting harmful micro-organisms and simultaneously boosting the immune system. It covers methods of virtual screening and computational validation of identified phytochemicals as potential antiviral agents against the SARS-CoV-2 virus. 70 colored figures.

Key Features:

1. Covers the molecular etiology of COVID-19 virus,

2. Covers guidance on drug formulation, hazard assessment, and clinical trials based on approved methods by regulatory organizations

3. Covers pharmacological, toxicological, and technically verified chemical composition of medicinal plants

4. Includes information about in vivo experiments and analysis of Humanoid Zebrafish trials

5. Includes methods of identifying antiviral agents against the SARS-CoV-2 virus

6. Includes chemical, analytical and technical studies of Coronil

7. Includes 70 images 7 chapters 8.

Includes a bibliography and appendix

The book is primarily intended as a primary resource for medical research scholars and researchers in pharmaceutical companies and as a secondary resource for B.A.M.S. students, medical postgraduate students, and Ayurveda enthusiasts.

Developing an effective program requires a sound administrative system and a supportive educational culture including the support of program handbooks, a Master’s project (Capstone), practicum, and skill development seminars. Experiential Teaching for Public Health Practice describes the underlying PBL and community framework for a teaching program along with a description of the competencies needed to meet workplace demands and educational accreditation requirements. It has been developed by members of University of Washington’s Community-Oriented Public Health Practice program (COPHP) curriculum. This curriculum mirrors core programmatic areas of population health, community development, quantitative research methods, environmental health, health behavior and health promotion, evaluation, policy, and management and leadership.

Key features include:

- Structured template outlining the basics of PBL programs

- Case examples given in each curricular area

- Detailed appendices with sample cases and links to original source documents

- A focus on principles of racial equality

This book is designed to give the reader hands-on help in designing and improving educational programs. It is suitable for all higher education administrators and faculty looking to improve the teaching and learning effectiveness of any academic program.

This book offers in-depth reviews of different techniques and novel approaches of using blockchain and artificial intelligence in smart healthcare services. The volume brings 14 reviews and research articles written by academicians, researchers and industry professionals to give readers a current perspective of smart healthcare solutions for medical and public health services.

The book starts with examples of how blockchain can be applied in healthcare services such as the care of osteoporosis patients and security. Several chapters review AI models for disease detection including breast cancer, colon cancer and anemia. The authors have included model design and parameters for the benefit of professionals who want to implement specific algorithms. Furthermore, the book also includes chapters on IoT frameworks for smart healthcare systems, giving readers a primer on how to utilize the technology in this sector. Additional use cases for machine learning for gesture learning. COVID-19 management, and sentiment analysis.

Exterior calculus is a branch of mathematics which involves differential geometry. In Exterior calculus the concept of differentiations is generalized to antisymmetric exterior derivatives and the notions of ordinary integration to differentiable manifolds of arbitrary dimensions. It therefore generalizes the fundamental theorem of calculus to Stokes' theorem.

This textbook covers the fundamental requirements of exterior calculus in curricula for college students in mathematics and engineering programs. Chapters start from Heaviside-Gibbs algebra, and progress to different concepts in Grassman algebra. The final section of the book covers applications of exterior calculus with solutions.

Readers will find a concise and clear study of vector calculus and differential geometry, along with several examples and exercises. The solutions to the exercises are also included at the end of the book.

This is an ideal book for students with a basic background in mathematics who wish to learn about exterior calculus as part of their college curriculum and equip themselves with the knowledge to apply relevant theoretical concepts in practical situations.