Bentham Science Publishers

Understanding the dispersion and the deposition of inertial particles convected by turbulent flows is a domain of research of considerable industrial interest. Inertial particle transport and dispersion are encountered in a wide range of flow configurations, whether they are of industrial or environmental character. Conventional models for turbulent dispersed flows do not appear capable of meeting the growing needs of chemical, mechanical and petroleum industries in this regard and physical environment testing is prohibitive. Direct Numerical Simulation (DNS) and Large Eddy Simulation (LES) have become powerful tools for the investigation of particle-laden turbulent flows with the help of advances in computing resources. The hybrid Eulerian-Lagrangian approach plays a key role in predicting inertial particle dispersion and deposition. This ebook explains the use of stochastic tools to enhance the accuracy of the Eulerian-Lagrangian large eddy simulation of particle-laden turbulent flows of practical interest. The book should be a useful resource for chemical, mechanical, petroleum and environmental engineering postgraduates and researchers interested in applying tractable yet powerful numerical tools to solve problems involving multiphase flows.

This book deals with structural failure (induced by mechanical, aerodynamic, acoustic and aero-thermal, loads, etc.) of modern aerospace vehicles, in particular high-speed aircraft, solid propellant rocket systems and hypersonic flight vehicles, where structural integrity, failure prediction and service life assessment are particularly challenging, due to the increasingly more demanding mission requirements and the use of non-traditional materials, such as non-metallic composites, in their construction. Prediction of the complex loading environment seen in high-speed operation and constitutive / fracture models which can adequately describe the non-linear behaviour exhibited by advanced alloys and composite materials are critical in analyzing the non-linear structural response of modern aerospace vehicles and structures. The state-of-the-art of the different structural integrity assessment and prediction methodologies (including non-destructive structural health monitoring techniques) used for the structural design, service life assessment and failure analysis of the different types of aerospace vehicles are presented. The chapters are written by experts from aerospace / defence research organizations and academia in the fields of solid mechanics, and structural mechanics and dynamics of aircraft, rocket and hypersonic systems. The book will serve as a useful reference document containing specialist knowledge on appropriate prediction methodologies for a given circumstance and experimental data acquired from multi-national collaborative programs.

This book explains different types of subharmonic and harmonic functions. The book brings 12 chapters explaining general and specific types of subharmonic functions (eg. quasinearly subharmonic functions and other separate functions), related partial differential equations, mathematical proofs and extension results. The methods covered in the book also attempt to explain different mathematical analyses such as elliptical equations, domination conditions, weighted boundary behavior. The book serves as a reference work for scholars interested in potential theory and complex analysis.

From the beginning of this century, there has been a dramatic increase in interest in the study of surface plasmon polaritons-based metallic subwavelength structures and learning. This is a refreshing concise book on issues and considerations in designing, nanofabrication and characterization of subwavelength plasmonic structures as well as their applications in imaging, superfocusing, semiconductor lasers, data storage, optical communications, biosensing, and immunoassays. The book can serve as a textbook for education and training as well as a reference book that aids research and development in those areas integrating light, photonics, nanotechnology, semiconductors, chemistry, and biology. Another aim of the book is to stimulate the interest of researchers, engineers, and businessmen to foster collaboration through multidisciplinary programs in this frontier science, leading to development and transition of the resulting technology. Both basic and applied aspects are presented in this book. Many illustrative worked-out examples and instructive exercises are given, which should prove to be particularly useful.

In the year 2000, approximately one million people died from suicide: a "global" mortality rate of 16 per 100,000, or one death every 40 seconds.

In the last 45 years suicide rates have increased by 60% worldwide. Suicide is now among the three leading causes of death among those aged 15-44 years (both sexes); these figures do not include suicide attempts up to 20 times more frequent than completed suicide. Suicide worldwide is estimated to represent 1.8% of the total global burden of disease in1998, and 2.4% in countries with market and former socialist economies in 2020. Although traditionally suicide rates have been highest among the male elderly, rates among young people have been increasing to such an extent that they are now the group at highest risk in a third of countries, in both developed and developing countries. Mental disorders (particularly depression and substance abuse) are associated with more than 90% of all cases of suicide; however, suicide results from many complex sociocultural factors and is more likely to occur particularly during periods of socioeconomic, family and individual crisis situations (e.g., loss of a loved one, employment, honour).

The economic costs associated with completed and attempted suicide are estimated to be in the billions of dollars. One million lives lost each year are more than those lost from wars and murder annually in the world. It is three times the catastrophic loss of life in the tsunami disaster in Asia in 2005. Every day of the year, the number of suicides is equivalent to the number of lives lost in the attack on the World Trade Center Twin Towers on 9/11 in 2001.

Everyone should be aware of the warning signs for suicide: Someone threatening to hurt or kill him/herself, or taking of wanting to hurt or kill him/herself; someone looking for ways to kill him/herself by seeking access to firearms, available pills, or other means; someone talking or writing about death, dying or suicide, when these actions are out of the ordinary for the person. Also, high risk of suicide is generally associated with hopelessness; rage, uncontrolled anger, seeking revenge; acting reckless or engaging in risky activities, seemingly without thinking; feeling trapped – like there’s no way out; increased alcohol or drug use; withdrawing from friends, family and society, anxiety, agitation, unable to sleep or sleeping all the time; dramatic mood changes; no reason for living; no sense of purpose in life.

Table 1: Understanding and helping the suicidal individual should be a task for all.

Suicide Myths

How to Help the Suicidal Person

Warning Sights of Suicide

Myth: Suicidal people just want to die.

Fact: Most of the time, suicidal people are torn between wanting to die and wanting to live. Most suicidal individuals don’t want death; they just want to stoop the great psychological or emotional pain they are experiencing

-Listen; -Accept the person’s feelings as they are; -Do not be afraid to talk about suicide directly -Ask them if they developed a plan of suicide;

-Expressing suicidal feelings or bringing up the topic of suicide; -Giving away prized possessions settling affairs, making out a will; -Signs of depression: loss of pleasure, sad mood, alterations in sleeping/eating patterns, feelings of hopelessness;

Myth: People who commit suicide do not warn others.

Fact: Eight out of every 10 people who kill themselves give definite clues to their intentions. They leave numerous clues and warnings to others, although clues may be non-verbal of difficult to detect.

-Remove lethal means for suicide from person's home -Remind the person that depressed feelings do change with time; -Point out when death is chosen, it is irreversible;

-Change of behavior (poor work or school performance) -Risk-taking behaviors -Increased use of alcohol or drugs -Social isolation -Developing a specific plan for suicide

Myth: People who talk about suicide are only trying to get attention. They won’t really do it.

Fact: Few commit suicide without first letting someone know how they feel. Those who are considering suicide give clues and warnings as a cry for help. Over 70% who do threaten to commit suicide either make an attempt or complete the act.

-Express your concern for the person; -Develop a plan for help with the person; -Seek outside emergency intervention at a hospital, mental health clinic or call a suicide prevention center

Myth: Don’t mention suicide to someone who’s showing signs of depression. It will plant the idea in their minds and they will act on it.

Fact: Many depressed people have already considered suicide as an option. Discussing it openly helps the suicidal person sort through the problems and generally provides a sense of relief and understanding.

Suicide is preventable. Most suicidal individuals desperately want to live; they are just unable to see alternatives to their problems. Most suicidal individuals give definite warnings of their suicidal intentions, but others are either unaware of the significance of these warnings or do not know how to respond to them. Talking about suicide does not cause someone to be suicidal; on the contrary the individual feel relief and has the opportunity to experience an empathic contact.

Suicide profoundly affects individuals, families, workplaces, neighbourhoods and societies. The economic costs associated with suicide and self-inflicted injuries are estimated to be in the billions of dollars. Surviving family members not only suffer the trauma of losing a loved one to suicide, and may themselves be at higher risk for suicide and emotional problems.

Mental pain is the basic ingredient of suicide. Edwin Shneidman calls such pain "psychache" [1], meaning an ache in the psyche. Shneidman suggested that the key questions to ask a suicidal person are ‘Where do you hurt?’ and ‘How may I help you?’. If the function of suicide is to put a stop to an unbearable flow of painful consciousness, then it follows that the clinician’s main task is to mollify that pain. Shneidman (1) also pointed out that the main sources of psychological pain, such as shame, guilt, rage, loneliness, hopelessness and so forth, stem from frustrated or thwarted psychological needs. These psychological needs include the need for achievement, for affiliation, for autonomy, for counteraction, for exhibition, for nurturance, for order and for understanding. Shneidman [2], who is considered the father of suicidology, has proposed the following definition of suicide: ‘Currently in the Western world, suicide is a conscious act of self-induced annihilation, best understood as a multidimensional malaise in a needful individual who defines an issue for which the suicide is perceived as the best solution’. Shneidman has also suggested that ‘that suicide is best understood not so much as a movement toward death as it is a movement away from something and that something is always the same: intolerable emotion, unendurable pain, or unacceptable anguish.

Strategies involving restriction of access to common methods of suicide have proved to be effective in reducing suicide rates; however, there is a need to adopt multi-sectoral approaches involving other levels of intervention and activities, such as crisis centers. There is compelling evidence indicating that adequate prevention and treatment of depression, alcohol and substance abuse can reduce suicide rates. School-based interventions involving crisis management, self-esteem enhancement and the development of coping skills and healthy decision making have been demonstrated to reduce the risk of suicide among the youth. Worldwide, the prevention of suicide has not been adequately addressed due to basically a lack of awareness of suicide as a major problem and the taboo in many societies to discuss openly about it. In fact, only a few countries have included prevention of suicide among their priorities.

Reliability of suicide certification and reporting is an issue in great need of improvement. It is clear that suicide prevention requires intervention also from outside the health sector and calls for an innovative, comprehensive multi-sectoral approach, including both health and non-health sectors, e.g., education, labour, police, justice, religion, law, politics, the media.

Emulsions (simple, mixed or multiple) are essentially pure substances, aqueous or organic binary solutions. The have a wide range of uses, including industrial cooling and heat transfer processes. This monograph gives a brief overview of supercooling, crystallization and melting processes within emulsions. Differential scanning calorimetrey (DSC) coupled with RX is the main technique used to demonstrate these processes. Temperature readings in this work have been defined taking into account known nucleation laws. These results have been used to show mass transfers occurring within mixed emulsions (solid ripening) or multiple emulsions (composition ripening), gas hydrate formation due to a chemical reaction between water and a diffuse specific compound, these phenomena being described by diffusive models. Other aspects of heat transfer process covered in this book include the latent energy released at crystallizations or absorbed at the melting (which alters the temperature field through emulsions), the kinetics of phase transformations and self-regulation of temperature in nodules containing phase changing materials. This monograph is intended for advanced chemistry graduates as well as industrial and chemical engineers working with cooling and heat transfer systems.

Surface enhanced Raman spectroscopy (SERS) is a technique applied in multidisciplinary research. Its use has tremendously grown in the last 40 years owing to improved nanofabrication, biomolecules extraction and sensitive signal acquisition techniques.

This book focuses on the underlying principles of SERS by emphasizing on basic concepts and background information about the subject. Chapters explain the physics of Raman spectroscopy while also indicating its relevance to designing protocols and methodologies for biosensing and imaging. The book gives updated and recent details on colloids and nanostructures, their fabrication, surface engineering and immobilization methods, all in context to SERS based biosensing.

Key Features:

- Covers basic knowledge and new research about surface enhanced Raman spectroscopy (SERS)

- Provides a complete framework on SERS based biosensing with concise chapters

- Focuses on different active molecules critical to SERS and associated developed nanoassemblies

- Presents information about ongoing research on SERS imaging applications

- Highlights bottlenecks of SERS technique in biosensing

- Includes references for further reading

This book serves as a reference book for researchers and academicians and will also provide a reasonable understanding on the topic of SERS to newcomers irrespective of their background in a simple manner. The book is of interest to all readers within the scientific community involved with Raman spectroscopy, including chemists, physicists, biologists, material scientists as well as biomedical engineers.

This monograph offers the reader an integrated point-of-view about the inflammatory response related to injury, infections and tumors. This integration is based on the hypothesis that the multiple pathophysiological mechanisms making up inflammation represent the re-expression of ontogenic mechanisms during early embryo development as well as the recapitulation of ancestral phylogenetic mechanisms. The relevance of the anti-inflammatory treatments is also highlighted with respect to polytraumatic patients, advances in stem cell research, embryology and the wound healing mechanism.

Readers of this book will have the chance of gaining a unique perspective about of the pathophysiological mechanisms involved in the multiple inflammatory conditions. This integrative concept about inflammation can be applied in biological investigation, as well as in clinical research and translational medicine.

Sustainability Studies: Environmental and Energy Management is a collection of reviews on topics on sustainability with the objective of informing the reader about the environmental impact of industrialization and the ways technology can be implemented to sustain it.

The book presents 11 chapters that focus on the environmental issues, waste management methods, and green chemistry for environmental-friendly production and construction. 2 chapters bring attention to important concepts that are central to sustainability, namely, environmental justice and climate change. The editors have ensured an adequate balance of theoretical concepts and practical information to give readers a broad overview of environmental sustainability. Each chapter is structured into easy-to-read sections that are suitable for readers who are learning about sustainability as part of their educational curriculum.

Sustainability Studies: Environmental and Energy Management is a primer on sustainability and environmental management for students and academics in environmental science, and engineering courses.

Sustainable Agriculture Applications Using Large Language Models examines how AI-powered tools can enhance decision-making, resource optimization, and knowledge dissemination across diverse agricultural contexts.

Spanning topics from crop management and pest control to water conservation and market analysis, the book features a multidisciplinary approach including real-world applications and case studies. It highlights how LLMs can support sustainable practices by analyzing agricultural data, improving communication with farmers, and enabling predictive insights. Special attention is given to ethical considerations and the responsible deployment of AI tools in rural and technologically evolving regions.

Key Features:

Demonstrates how LLMs support sustainable agriculture practices

Showcases AI-driven approaches in crop, pest, and water management

Presents real-world applications and case studies across regions

Explores ethical considerations and responsible AI deployment in agriculture

Analyzes LLM integration in agricultural education, communication, and policy

The urgency of exploring alternative energy sources, especially in regions so detrimentally affected by current energy practices on environmental, humanitarian and political levels warrants a crucial effort in raising awareness and activism about renewable energy and sustainable development.

Sustainable Solar Energy Systems is a primer on the application of solar energy technology for sustainable development. This handbook starts with an introduction to basic concepts of solar energy, describes the mechanisms and benefits of related technologies, and presents a case study in an Arabian poultry farm. The book also includes details on how to conduct economic feasibility studies of solar power projects. The book is a suitable reference for general readers or students undertaking environmental science or engineering courses with specific modules on solar energy projects. Readers will be able to understand the benefits of solar energy systems in the context of an increasing concern about the use of renewable energy under conditions of global warming and declining fossil fuel reserves.

I joined NEC in 1968 and was assigned to the circuit development department of the computer division. My first work was the circuit design of the switching mode power supply (SMPS) for the mainframe of the computer system. My job area was expanded to development of the design rule and to standardization of all over the electric and electronics parts for the non-logic circuit. Non-logic circuit was categorized to except the gate-array which forms the logic circuit of the mainframe. The experiment of SMPS was considered to be dangerousness and no one wanted to design. Therefore, my development of the power supply system (PSS) including the circuit design of SMPS was continued. The electric current of the mainframe and the supercomputer was reached to several thousand amperes. The critical problem of PSS was the heat dissipation and the electromagnetic interference (EMI) against the logic circuit. In 1992, the full-scale R&D of EMC became necessary hastily. I was nominated and transferred to the chief managing researcher of the established EMC engineering center in NEC Laboratories. I had believed that the switching mode circuit (SMC) including the digital circuit and SMPS circuit will be improved greatly if the EMC problem is solved. However the deep R&D was difficult because the actual fruits in every year were required strongly. Therefore, his knowledge of the science concerning EMC was not deepened enough. However I could understand the actual status of technologies of the electronics and electrics widely and the basic knowledge about how to approach the science as well as R&D could be learned. During this time, I completed PhD course and received the PhD. degree from Kyushu University, lectured in Kyushu University and Tohoku University for one year each, and executed several national projects by the cooperation of his colleague in NEC and of the supporters in the industrial society and academia. These are considered to be my best harvest in NEC Laboratories. I had decided to continue R&D for solving EMC problem of SMC after his retirement and to try the commercialization of the fruit of R&D. I established ICAST which is the abbreviation of the innovative circuit and system technologies in 2005. The solitary electromagnetic (SEMW) theory was advocated and the novel technologies including the low impedance lossy line (LILL) and the matched impedance lossy line (MILL) were invented based on the SEMW theory.

Two purposes exist in this eBook. The first is to be validated the SEMW theory by the academia and the industrial society. The second is the contribution to the growth of the industry in the world by the technologies of LILL and MILL.

Synthesis and Applications of Semiconductor Nanostructures consists of 15 chapters that focus on synthesis, characterization and multifaceted potential applications of semiconductor nanostructures, metal organic frameworks (MOFs) and nanostructure impregnated metal-organic frameworks (MOFs). Special materials included in the volume include doped glasses, functionalized carbon nanotubes, doped graphene and graphene nanoribbons. The contributions highlight numerous bottom-up and top-down techniques for the synthesis of semiconductor nanostructures. Several industrial processes such as hydrogen production, wastewater treatment, carbon dioxide reduction, pollution control and oxidation of alcohols have been demonstrated in the context of semiconductor nanomaterial applications. The volume also has chapters dedicated to updates on the biomedical applications of these nanomaterials. This volume is a timely resource for postgraduate students, academicians, researchers and technocrats, who are involved in R&D activities with semiconductor nanomaterials and metal organic frameworks.

Synthesis of Nanomaterials is a beginner's guide to the synthesis and characterization of biomaterials for medical devices and implants. It presents 8 chapters explaining the use of biomaterials in medicine and pharmacology. The concepts are explained with the guidance of specialists who present the principal techniques and methods to obtain high-performance polymers and composite materials.

Starting with an introduction to the subject, the book explains nanomaterials synthesis and progresses towards engineering applications. The chapters also cover modern biomaterials such as stimuli-responsive biomaterials, hydrogels, and self-healing materials.

One chapter is dedicated to computational and theoretical techniques in biomedicine and a final chapter covering microencapsulation for advanced drug delivery rounds up the contents.

Synthesis of Nanomaterials is a primary reference book for undergraduate and graduate students as well as professors involved in multidisciplinary research and teaching programs.

Synthesis, Application and Future Perspectives of Smart Nano-materials (Part 1) provides a comprehensive overview of the latest advancements in smart nanomaterials, their synthesis, and diverse applications. This book explores nanomaterials' design, fabrication, and functionality, covering key areas such as catalysis, energy storage, environmental remediation, and biomedical applications. Topics include catalytic hydrogen evolution reactions, core-shell metal/carbon nanomaterials, carbon quantum dots, nanostructured metal oxides, and TiO₂ nanoparticles. It bridges fundamental concepts with real-world applications, fostering innovation in next-generation materials.

Key Features:

- Covers synthesis, characterization, and applications of smart nanomaterials.

- Explores nanomaterials for catalysis, energy storage, and environmental applications.

- Discusses advanced fabrication techniques and future technological prospects.

Systemic lupus erythematosus (SLE) is an autoimmune disease. SLE affects many parts of the body, with joint pain in the knees and hands being commonly reported symptoms. Arthritis is, therefore, one of the most common symptoms of the disease.

This book comprehensively summarizes information about SLE for medical professionals and students. The volume illustrates the process of making accurate diagnoses through systematic interpretation of ABCDEGFGI parameters: A (Alignment): malalignment and deformation; B (Bone): bone changes; C (Capsular lesions): cartilage and intra-articular lesions; D (Distribution): four dimensional distributions; E (Extra-bone): extra-articular soft tissue; F (Further information): further additional medical information; G (Goal): general analysis and integrated comprehensive diagnosis; H (Heal and Heath): treatment and prognosis; and I (Immunological analysis): immunological interpretations.

Key Features:

- Presents information about the clinical features of SLE and differential diagnosis through 11 chapters

- Covers both rheumatic symptoms and systemic symptoms

- Provides a comprehensive approach to SLE diagnosis and management which blends both rheumatology and radiology

- Explains the ABCDEFGI system for diagnosing and treating SLE patients

- Includes more than 750 detailed figures illustrating important information

- Includes references for further reading

The book is an informative resource for a wide range of scholarly and professional readers who may encounter SLE patients in clinical settings: rheumatologists, orthopedists, radiologists, physiatrists, immunologists, pediatricians, general physicians, medical technicians, caregivers and specialists in internal medicine.

This book explores the intricate world of livestock sciences and production through the lens of systems biology. Offering a comprehensive exploration of both fundamental and advanced aspects, it unearths the potential of systems biology in the realm of livestock. The book presents 13 edited chapters on cutting-edge knowledge about systems biology and omics technology, showcasing genomics, transcriptomics, proteomics, metabolomics, and more. It illuminates the role of systems biology in livestock and disease management. Readers will learn about power of technologies that merge computational biology, nanobiotechnology, artificial intelligence, and single-cell sequencing. Each chapter is written by scientific experts and includes references for further reading.

The book covers 4 key themes:

Introduction to Systems Biology in Livestock Science: Uncover the foundation of integrating systems biology with omics data for animal scientists.

Multi-scale Modeling Techniques: Explore how multi-scale modeling is shaping the future of system biology.

Livestock Viral Diseases: Gain insights into how systems biology is revolutionizing our understanding of livestock viral diseases.

Single Cell RNA-Sequencing: Understand the potential of this advanced technique in studying livestock animals at a cellular level.

This book is a timely resource for students and researchers, offering a pathway to comprehend the crucial role systems biology plays in sustainable livestock production and management.

Taurine, or 2-aminoethanesulfonic acid, is one of the most abundant sulfur-containing amino acids in the human body. It is found in the heart, brain, retina, and skeletal muscles, and is synthesized in the pancreas. Studies have revealed that taurine is of high physiological importance: it protects against pathologies associated with mitochondrial diseases, and linked processes like aging, metabolic syndrome, cancer, cardiovascular diseases, and neurological disorders. It is also used as a nutritional supplement.

Taurine and the Mitochondrion: Applications in the Pharmacotherapy of Human Diseases explores the significance of taurine in the biology of mitochondria. It also explains its role as a pharmacological agent for treating different diseases. Readers will gain an insight into the crucial role it plays in human physiology and the benefits of taurine supplements.

Topics covered in this reference include

- Synthesis of taurine and its dietary sources

- The Role of taurine in mitochondrial health

- Taurine as a neurotransmitter

- Beneficial effects of taurine in physiological systems such as the reproductive system, renal system, and the gastrointestinal tract

- Hepatoprotective and anti-inflammatory properties of taurine

- The anti-aging promise of taurine supplementation

- Role of taurine supplementation in obesity

Technical Advances in Pharmacy: An Overview examines the convergence of digital transformation, automation, and data intelligence in revolutionizing drug discovery, formulation, and healthcare delivery.

Across twelve in-depth chapters the book presents a forward-looking exploration of how emerging technologies are reshaping the landscape of pharmaceutical sciences. The book also covers cutting-edge developments such as artificial intelligence in drug discovery, pharmacogenomics and personalized medicine, blockchain in pharmaceutical supply chains, 3D printing of dosage forms, tele pharmacy, data analytics, and automation in pharmacy practice. By integrating computational modelling with experimental techniques, the text highlights the translational potential of modern technologies in enhancing drug development, patient adherence, and clinical outcomes.

Serving as both a reference and a roadmap, this volume bridges traditional pharmaceutical foundations with next-generation innovations, offering readers an insightful perspective on the technological evolution shaping the future of pharmacy.

Key Features

Examines the role of artificial intelligence, pharmacogenomics, and data analytics in modern drug discovery.

Explores blockchain, automation, and robotics as enablers of efficient and transparent pharmacy systems.

Integrates computational modeling with experimental approaches for enhanced drug formulation and testing.

Highlights 3D printing, telepharmacy, and RegTech as transformative tools in pharmaceutical innovation.

Bridges classical pharmaceutical sciences with emerging digital and biotechnological advancements.

Medicinal chemists around the world have been inspired by nature and have successfully extracted chemicals from plants. Research on enzymatic modifications of naturally occurring compounds has played a critical role in the search for biologically active molecules to treat diseases.

This book set explores compounds of interest to researchers and clinicians. It presents a comprehensive analysis about the medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, molecular modelling studies) of different compounds. Each chapter brings contributions from known scientists explaining experimental results which can be translated into clinical practice.

Volume 2 gives (1) a detailed overview of the sesquiterpenes polypharmacology, (2) an interesting journey around the world of cannabinoids that reveals the development of new synthetic & derivatives, (3) the design of specific formulations to overcome the volatility of small sized terpenes-based essential oils, (4) an update on the latest generations of endoperoxides endowed with antimalarial activity and finally (5) a summary of MedChem strategies to fix the most common issues in formulating terpene derivatives (like low potency and poor solubility).

The objective of this book set is to fulfill gaps in currently acquired knowledge with information from the recent years. It serves as a guide for academic and professional researchers and clinicians.

Natural elements and cosmic phenomena in space, such as asteroids, comets, meteors, black holes and super bubbles pose a threat to the planet Earth and spacefarers in the near-Earth environment. Terrestrial and Extraterrestrial Space Dangers describes these dangers in the near-Earth outer space environment. The uniquely risky nature of rocket transportation is documented and quantified. The human health consequences for vision, muscles, and the neurovestibular system, for instance, on exposure to an outer space environment, are also explained in this book. Readers will benefit from the extensive information offered within this text which is also accompanied with a bibliography of references. This book offers a comprehensive primer for anyone interested in space travel and associated risk assessment.

Textbook of Advanced Dermatology: Pearls for Academia and Skin Clinics is an essential reference for practicing dermatologists in hospitals and clinics. The book aims to provide interesting tips that cannot be found in traditional dermatology handbooks. The contributors include top minds in dermatology and related fields such as Joe Niamtu, Samuel Lam, and Steven Feldman. Topics in the book include novel, original formulations for topical compounds, ways to improve patient adherence to prescriptions, business tips, novelties in skin surgery, and solutions for preventing patient complaints and legal suits. The book also highlights the author's personal experiences gained over many years in improving everyday clinical dermatology practice.

The book is divided into 5 sections each representing 'pearls' of advice: Teaching Pearls, Medical Pearls, Publication Pearls, Procedural Pearls, and Business Pearls, encompassing all of the broad realm of dermatology.

This book is a concise textbook of iatrogenic pathology. Chapters cover iatrogenesis relevant to a broad range of medical subspecialties (cardiology, gastroenterology, gynecology, neurology, endocrinology and much more). The book presents an introduction to iatrogenesis which is followed by chapter-wise descriptions of iatrogenic lesions (lesions due to adverse drug reactions, lesions occurring during diagnosis and consequences of various therapeutic interventions) of the organs and systems of the body.

This textbook is a handy resource on iatrogenic pathology for medical students and working professionals (clinical and nursing staff) involved in a range of medical subspecialties

A major goal of integrative research is understanding regulatory networks to such an extent as to allow researchers to model developmental and stress responses. Regulatory networks of living systems include complex and vast interactions between proteins, metabolites, RNA, various signaling molecules and DNA. One aspect of systems biology is understanding the dynamics of protein-DNA interactions affecting gene expression that are caused by transcription factors (TFs) and chromatin remodeling factors. This e-book provides a resource for summarizing current knowledge eukaryotic transcription and explores cis-elements and methods for their analysis, prediction and discovery. The book also presents an overview of exploring gene regulatory networks, chromatin, and miRNAs. Information about state-of-the-art techniques for the determination of TF - cis-element interactions in vivo and in silico give cutting edge insights on how genomic-scale research is being approached. The Analysis of Regulatory DNA provides readers with both the necessary background knowledge and provocative, up-to-date insights aimed at sparking new and vibrant experimental designs for understanding and predicting cis-elements in the eukaryotic genome.