Bentham Science Publishers

This reference is the definitive guide to common neurodegenerative diseases that affect humans. The book covers mechanisms of some of the most well-known neurodegenerative diseases, their biomarkers, neuropharmacology, and emerging treatment strategies.

The book introduces the subject of neurodegeneration by outlining the biochemistry, pathophysiology and multifactorial neurological mechanisms (the role of genetics, environmental factors and mitochondrial damage, for example). Next, it explains some of the most studied diseases, namely, Parkinson's Disease, Alzheimer's Disease, Huntington's Disease, and Multiple Sclerosis. Subsequent chapters delve into current knowledge about diagnostic and immunological biomarkers, followed by a summary of novel therapeutic strategies.

Special attention has been given to the role of medicinal plants in attempting to treat neurodegenerative diseases, as well as the public health burden posed by these conditions.

Key Features - give readers an overview of multifactorial disease mechanisms in neurodegeneration

- covers some major neurodegenerative diseases in detail

- covers diagnostic and immunological biomarkers

- explores current therapeutic strategies and drug targets in common neurodegenerative diseases

- offers a simple presentation with references for advanced readers

The book is a suitable reference for all readers, including students, research scholars, and physicians who are interested in the mechanisms and treatment of neurodegenerative diseases.

NBE is the official journal of the Institute of Complex Medical Engineering (ICME). The journal promotes the best interdisciplinary research in neuroscience and biomedical engineering. NBE welcomes contributions in any domain of neural and biomedical engineering ranging in content from practical/clinical applications through experimental science, technological developments to quantitative and/or statistical methodology discussions. NBE publishes the following article types: original articles, research reviews, and book reviews.

The goal of this journal is to establish a new forum for this interdisciplinary field so neuroscientists and biomedical engineers can publish their research works in one periodical. NBE is devoted to bridge the gap between Neuroscience and Biomedical Engineering , and to foster the mutual understanding in both fields.

Typical topics include, but certainly are not limited, to the following:
Neural Technology and Neural Rehabilitation
Neurology and Signal Processing
Biomedical Informatics
Biomechanics and Neural Control
Theoretical and Computational Neuroscience
Imaging Neuroscience

Key Features:

- Original research papers and special issues for topics
- Basic neurosciences, and biomedical engineering technologies
- Existing and potential clinical applications
- Periodic ‘Review Papers’ from world-recognized experts
- International scope
- No page charges
- Rapid publication times
- Free color in electronic version

Increasingly global and online social interactions and financial transactions involve digital data, computing devices and the internet. With cloud computing, remote computing, enterprise mobility and e-commerce on the rise, network security has become a priority. Selecting an appropriate algorithm and policy is a challenge for computer security engineers, as new technologies provide malicious users with opportunities to intrude into computer networks.

New Age Cyber Threat Mitigation for Cloud Computing Networks provides cloud and network engineers answers to cybersecurity challenges. It highlights new options, methodologies and feasible solutions that can be implemented in cloud architecture and IT Infrastructure, thereby securing end users. Chapters cover many topics related to cyber threats in the modern era.

These topics include:

Ransomware and DDoS attacks

Security algorithms

Design and implementation solutions for resilient and fault-tolerant cloud and network services

Security policy

End user data security The book is an essential resource for anyone involved in cloud computing and network security, including learners, professionals and enthusiasts.

New Avenues in Drug Discovery and Bioactive Natural Products is the second volume of the Natural Medicine book series. It is devoted to current research in drug discovery from natural sources. The volume features 13 chapters that cover modern analytical and scientific approaches. The book starts with chapters on advanced analytical and research techniques, such as genomic mining, quality control of herbal drugs, DNA fingerprinting, high-throughput screening, molecular docking and extraction techniques. The contributors provide a summary of challenges for researchers and commercial applications where possible. The book also features chapters dedicated to specific medicinal agents that target a disease (glycosides, SARS-CoV2 spike protein inhibitors, and andrographolides. The collection of important research topics in natural product chemistry aims to help the scholars and researchers in the scientific community that are involved in the extraction and development of new medicines.

This book is recommended for readers who are interested in or work with current theoretical and experimental research in medicinal chemistry, with an emphasis on computer aided-drug design and organic synthesis for therapeutic purposes. This book encompasses the multidisciplinary field of medicinal chemistry which overlaps the knowledge of chemistry, physics, biochemistry, biology and pharmacology.

New Drugs Targeting Antibiotic-Resistant Bacteria: Recent Advances examines the molecular, pharmacological, and clinical dimensions of resistance development and highlights innovative therapeutic approaches aimed at overcoming multidrug-resistant organisms (MDROs), providing an in-depth exploration of emerging strategies to combat one of the most urgent public health challenges of our time—antimicrobial resistance (AMR).

Beginning with the mechanisms underlying bacterial resistance such as β-lactamase production, efflux pump activity, and membrane protein modification, the text underscores the growing threat posed by ESKAPE pathogens and CDC-classified priority infections. Chapters also explore cutting-edge interventions including bacteriophage therapy, discovery of novel antibacterial compounds from natural sources, and the use of nanoparticles and quorum-sensing inhibitors to suppress bacterial virulence.

Further sections discuss carbapenemase-mediated resistance, emphasizing enzyme classification, detection strategies, and the importance of clinical microbiology in guiding antibiotic stewardship. By integrating one-health perspectives that consider human, animal, and environmental dimensions, this book presents a holistic roadmap for addressing resistance evolution through innovation and responsible antibiotic use.

Key Features

Examines the molecular mechanisms driving antibiotic resistance in key bacterial species

Explores bacteriophage therapy as a promising alternative to conventional antimicrobials

Discovers natural-source compounds and novel drug leads for future antibiotic development

Analyses carbapenemase-mediated resistance and clinical detection techniques

Evaluates new therapeutic approaches including nanoparticle-based treatments and quorum-sensing inhibition

Promotes the one-health approach to tackling multidrug-resistant organisms globally

Congenital heart diseases are the most common neonatal malformations, ranging from 8 to 15/1000 live births in various communities. Improvement of knowledge in the genetic and etio-pathogenic aspects of these malformations as well as the technical advances of diagnostic and therapeutic tools have brought about a significant improvement in overall long-term patient outcome over the last few decades. This e-book is an update on the most recent genetic, diagnostic and therapeutic aspects of this pediatric cardiology. Specifically, the book explains, in detail, recent acquisitions in the field of interaction between the genome and heart development, advances in diagnostic non-invasive techniques and novel therapeutic applications of the percutaneous and "hybrid" cardiologic/surgical procedures. These developments in diagnostics and therapeutics will be extremely valuable for both pediatric and adult cardiologists treating patients with congenital heart defects.

The monograph is a summary of methods used to study pain receptors and the results obtained in some experiments designed to study the effect of non-opioid analgesics. The molecular mechanisms of nociceptive information control in primary sensory nociceptive neurons are described based on investigations of the membrane signaling cascade (opioid-like receptor → Na+,K+-ATPase → NaV1.8 channel) observed by the authors. Based on this data, the authors conclude that the modulation of NaV1.8 channels responsible for the coding of noxious signals can be carried out due to two novel targeting mechanisms. The first of these is the activation of opioid-like receptors; the second is the activation of Na+/K+-ATPase as a signal transducer. The development of a novel class of analgesics that trigger these mechanisms should lead to a successful solution to the problem of chronic pain relief.

Chapters of the monograph cover the general methods used in studying nociceptive pain (including the patch-clamp method), and the mechanism behind the binding of different ligands to these receptors such gamma-pyrones, gamma-pyridines and cardiotonic steroids.

This monograph is a valuable reference for neuroscientists, pharmacologists and allied researchers studying pain receptors for the development of safe and effective analgesics.

Terraforming is the process of modifying a planet, moon, or other body to a more habitable atmosphere, temperature, or ecology. The idea of terraforming or colonizing other planets has recently become a topic of intense scientific interest and public debate. Geoengineering and terraforming, at their core, have the same goal: to enhance or revive the ability of a specific environment to support human life, society, and industry. New Worlds: Colonizing Planets, Moons and Beyond examines extra-terrestrial colonization plans with a critical eye. The ten chapters of the book provide a detailed review of the demographic and economic reasons behind this space imperative, technical and ecological solutions to improve the settlement of our own planet, enhancements of our current space industry. The book also covers interesting topics such as the terraformation of Mars, the moon, and other planets like Venus, colonizing the outer solar system (and beyond), and the ethical considerations in favor of space expansion. This simple, yet informative treatise is an essential read for anyone interested in the subject of space colonization

Nitrogen containing compounds produced by industrial processes are pollutants which pose a significant environmental and health hazard. There are a number of processes that have been devised for removing nitrogen compounds from wastewater.

This reference book summarizes different denitrification methods for wastewater processing. The book introduces readers to toxic nitrogen compounds responsible for water pollution. This introduction is followed by chapters which explain different nitrogen removal methods including conventional methods, biological methods, food industry wastewater treatment and new approaches towards environmental pollution remediation: Bio Electrochemical Systems (BESs). This book is a handy reference guide for industrial and environmental engineers and students learning about wastewater management and industrial denitrification.

Non-alcoholic fatty liver disease (NAFLD) is a common cause of elevated liver enzymes and chronic liver disease in Western countries. NAFLD is characterized by elevated liver enzymes in the absence of alcohol consumption and secondary causes of liver disease. It is an independent predictor of future risk of cardiovascular diseases, type 2 diabetes and metabolic syndrome (hypertension, abdominal obesity, dyslipidemia, glucose intolerance).

This book is a quick reference guide for medical students and professionals about NAFLD. Readers will find a summary of epidemiology, clinical features, diagnosis, imaging techniques, histopathology, and disease management. The book also presents information about NAFLD linked with hepatocellular carcinoma and guidelines for treating NAFLD in pediatric patients. Each chapter presents information in a simple, structured manner making this text an ideal handbook for supplementing hepatology modules in medical curricula.

Recent Advances in Analytical Techniques is a series of updates in techniques used in chemical analysis. Each volume presents information about a selection of analytical techniques. Readers will find information about developments in analytical methods such as chromatography, electrochemistry, optical sensor arrays for pharmaceutical and biomedical analysis. Novel Developments in Pharmaceutical and Biomedical Analysis is the second volume of the series and covers the following topics:

o Chromatographic assays of solid dosage forms and their drug dissolution studies

o UHPLC method for the estimation of bioactive compounds

o HILIC based LC/MS for metabolite analysis

o In vitro methods for the evaluation of oxidative stress

o Application of vibrational spectroscopy in studies of structural polymorphism of drugs

o Electrochemical sensors based on conductive polymers and carbon nanotubes

o Optical sensor arrays for pharmaceutical and biomedical analyses

o Chemical applications of ionic liquids

o New trends in enantioanalysis of pharmaceutical compounds

Novel Drug Delivery Systems (Part 2) covers the advanced techniques and innovations transforming pharmaceutical sciences, with a focus on enhancing drug efficacy and patient outcomes. This comprehensive guide explores a wide array of delivery methods, including nasopulmonary, transdermal, ocular, nanotechnology-based, implantable, and controlled-release injectables. Each chapter provides an in-depth analysis of these unique delivery routes, presenting both foundational knowledge and the latest technological advancements in the field.

Designed for students, researchers, and professionals in pharmaceuticals and medicine, this book bridges basic concepts with cutting-edge practices, emphasizing the science and impact of controlled drug delivery.

Key Features:

- Detailed exploration of nasopulmonary, transdermal, ocular, and implantable delivery systems

- Insight into nanotechnology's role in drug delivery

- Comprehensive coverage of controlled-release injectables

Progress in Computational Physics is an e-book series devoted to recent research trends in computational physics. It contains chapters contributed by outstanding experts of modeling of physical problems. The series focuses on interdisciplinary computational perspectives of current physical challenges, new numerical techniques for the solution of mathematical wave equations and describes certain real-world applications.

With the help of powerful computers and sophisticated methods of numerical mathematics it is possible to simulate many ultramodern devices, e.g. photonic crystals structures, semiconductor nanostructures or fuel cell stacks devices, thus preventing expensive and longstanding design and optimization in the laboratories.

In this book series, research manuscripts are shortened as single chapters and focus on one hot topic per volume.

Engineers, physicists, meteorologists, etc. and applied mathematicians can benefit from the series content. Readers will get a deep and active insight into state-of-the art modeling and simulation techniques of ultra-modern devices and problems.

The third volume - Novel Trends in Lattice Boltzmann Methods - Reactive Flow, Physicochemical Transport and Fluid-Structure Interaction - contains 09 chapters devoted to mathematical analysis of different issues related to the lattice Boltzmann methods, advanced numerical techniques for physico-chemical flows, fluid structure interaction and practical applications of these phenomena to real world problems.

This textbook is intended as a guide for undergraduate and graduate students in engineering, science and technology courses. Chapters of the book cover the numerical concepts of errors, approximations, differential equations and partial differential equations. The simple presentation of numerical concepts and illustrative examples helps students and general readers to understand the topics covered in the text.

Numerical Methods and Implementation in Geotechnical Engineering explains several numerical methods that are used in geotechnical engineering. The first part of this reference set includes methods such as the finite element method, distinct element method, discontinuous deformation analysis, numerical manifold method, smoothed particle hydrodynamics method, material point method, plasticity method, limit equilibrium and limit analysis, plasticity, slope stability and foundation engineering, optimization analysis and reliability analysis. The authors have also presented different computer programs associated with the materials in this book which will be useful to students learning how to apply the models explained in the text into practical situations when designing structures in locations with specific soil and rock settings.

This reference book set is a suitable textbook primer for civil engineering students as it provides a basic introduction to different numerical methods (classical and modern) in comprehensive readable volumes.

Various estimates suggest that between 30-40% of all human cancers are related to dietary patterns. Strong epidemiological evidence from population and twin studies points to dietary constituents that either contribute or protect against the development of various forms of cancer.

This e-book reviews some traditional and relatively new areas of nutrition and cancer. Epidemiological data is combined with molecular biology research and, where available, clinical trial data. The emerging science of "Nutrigenomics" is discussed with chapters on the biological role of various nutrition components from red wine, peppers, green tea, fish oil, cruciferous vegetables, retinoids; and the intersection of nutrition and epigenetics in hematopoiesis.

This e-book will be of interest to researchers in the nutrition and cancer field, physicians in family and community medicine, internal medicine and oncology, as well as dieticians providing counseling to cancer patients and cancer survivors.

Nutritional Biochemistry: From the Classroom to the Research Bench aims to provide students and readers with a detailed, simplified, and comprehensive account of the relationship between nutrition and metabolism.

A key feature of this textbook is a comparative approach on the subject of nutritional biochemistry which helps to explain the differences in metabolism, nutrient requirement, and sometimes in the molecular pathways between mammalian and non-mammalian species.

Chapters give an overview of the need of food and water (chapter 1), before describing the cell and organ system components (chapter 2). The textbook then focuses on the regulation of food intake from the factors influencing appetite to the central and peripheral underlying mechanisms (chapters 3-5).

Water intake and regulation in the body are covered (chapter 6), along with key topics of protein, carbohydrate, and lipid metabolism (chapters 7, 8, and 9), including their digestion, absorption, transport, utilization, synthesis, degradation, and molecular regulation. A brief summary concludes the book (Chapter 10).

This book serves as a textbook for students and faculty in beginner courses in biochemistry and nutrition and is designed to give learners a comprehensive understanding of the topic to help them when considering a career in research.

Unlock success in pharmaceutical exams with Objective Pharmaceutics: A Comprehensive Compilation of Questions and Answers for Pharmaceutics Exam Prep. This guide is meticulously crafted to tackle the challenges of pharmaceutics exams through a diverse range of questions. It covers multiple choice questions, concise one-liners, and true/false statements, mirroring the formats commonly found in drug inspector, pharmacist, GPAT, nursing exams, and more.

Key Features:

Exam-Ready Questions: Prepare for a variety of medical exams with more than 2000 carefully curated questions.

Diverse Testing Formats: Master multiple choice, one-liner, and true/false questions for a well-rounded exam readiness.

Broad Assessment: Tailored for drug inspectors, pharmacists, GPAT aspirants, and other medical professionals.

Build Thinking Capabilities: Progress from simple to challenging questions, enhancing critical thinking skills.

This thorough guide empowers you to learn the key topics in pharmaceutics and navigate the most challenging questions in your exam prep journey.

Ukot's Back to Basics MCQs: Obstetrics and Gynecology (Volume 1) is a structured single-best-answer (SBA) multiple-choice book designed to strengthen core knowledge in obstetrics and gynecology. Each MCQ presents a stem with four options, guiding learners to identify the best possible answer, while the companion notes provide detailed explanations to reinforce key principles and clinical reasoning.

The book covers essential topics in both obstetrics (including antenatal care, abnormal presentations, multiple pregnancy, labor complications, operative deliveries, hypertensive disorders, diabetes in pregnancy, hemorrhage, and the puerperium) and gynecology (including abnormal uterine bleeding, miscarriages, ectopic pregnancy, infertility, menstrual disorders, PCOS, STIs, contraception, fibroids, ovarian tumors, and cervical lesions). Supplementary chapters on differential diagnoses broaden clinical decision-making by addressing common and complex scenarios encountered in practice.

Key Features:

Presents SBA-format MCQs with clinically relevant stems and answers

Provides detailed notes explaining reasoning, management, and guidelines

Covers both obstetrics and gynecology comprehensively, from common to complex conditions

Includes chapters on differential diagnoses to sharpen diagnostic skills

Supports self-assessment, revision, and exam preparation in a practical format.

This comprehensive handbook delves into the essence of Occupational Health and Safety (OHS), exploring the dynamic interplay between regulations, practical methodologies, and the broader impact of OHS on organizations. The goal of the book is to help readers understand OHS practices in the workplace and how to implement a plan. 

Chapter 1 establishes the conceptual framework of OHS and provides a foundational understanding of the subject. Moving forward, Chapters 2 and 3 dive into the international and national legal requirements, giving a comparative overview of OHS legislation in the EU and specific regulations in Romania, Italy, and Spain. 

Chapter 4 introduces readers to risk assessment tools and the OHS management process, while Chapter 5 emphasizes the importance of performance monitoring and measuring. 

Chapter 6 presents a step-by-step risk assessment methodology. 

Finally, Chapter 7 explores the significant impact of OHS on overall company performance, integrating ergonomics and organizational resilience. 

Key Features: 

Combines theoretical insights with practical applications for academics and OHS professionals. 

Offers an up-to-date analysis of OHS regulations, with a focus on EU guidelines and specific regulations for Romania, Italy, and Spain. 

Provides knowledge on risk assessment tools and performance monitoring methods for effective safety measures. 

Highlights the essential relationship between OHS and company performance with real-world examples and a systems approach. 

The book is ideal for a wide range of readers, including OHS trainees, professional safety managers, policymakers, researchers and students studying OHS practices, safety regulations and its organizational impact.

Oesophago-gastric Surgery is a reference manual which addresses the core knowledge needs of surgical trainees in oesophago-gastric surgery as well as established consultants in oesophago-gastric surgery and other specialties. The book features a practical and user-friendly format for the benefit of undergraduate and professional readers. The editors have carefully included information that aligns with gastroenterology specialization curricula.

Chapters in the first part cover all introductory topics about oesophagal and gastric surgery including anaesthesia, perioperative care, nutrition and physiology. This part concludes with details on various disorders of the oesophagus, Barret’s oesophagus, and reflux disease.

Older Women: Current and Future Challenges of Professionals With An Aging Population is about older women and the unique challenges they face now and in coming decades. Elderly women face problems that require response from multiple service providers in the social welfare, health care and legal sectors. Due to the complexity of the various issues and the multi-systemic responses required to address these problems among diverse groups, an interdisciplinary perspective in a multicultural context needs to be examined. This book is an attempt to explain the multidisciplinary facets of social work with elderly women. Readers are also introduced to the ethical issues and challenges caused by economic disparities and are also provided with guidelines on potential responses and intervention strategies to such difficulties. Readers are also introduced to the concept of cultural competence in terms of working with aged women.

The integration of theory, research and practice in this book makes it a valuable resource for academicians and working professionals who are or will be in frequent contact with older adults.

Multiple biotic and abiotic environmental factors may constitute stresses that affect plant growth and yield in crop species. Advances in plant physiology, genetics, and molecular biology have greatly improved our understanding of plant responses to stresses. This book details on technologies that have emerged during the past decade and have been useful in studying the multigenicity of the plant abiotic stress response. Upstream molecular mechanisms are involved in the plant response to abiotic stress, above all in the regulation of timings and amount of specific stress responses. Post-transcriptional mechanisms based on alternative splicing and RNA processing, as well as RNA silencing define the actual transcriptome supporting the stress response. Beyond protein phosphorylation, other post-translational modifications like ubiquitination and sumoylation regulate the activation of pre-existing molecules to ensure a prompt response to stress factors.

The text in this book deals with the importance of -omics approaches like Genomics, Metabolomics and Proteomics in abiotic stress tolerance. Large scale analytical approaches provide detailed information about the structure and complexity of signaling networks, identify subsets of genes or activities that are correlated to given stress factors and reveal unexpected or previously uncharacterized biochemical interactions.

To the best of our knowledge no book on -Omics studies in relation to Plant Abiotic Stress Tolerance is available in the market. This book should therefore be a valuable asset for the readers.

The Microfabrication technology has stimulated a plurality of lab-on-a-chip research for biomedical researchers and health care practitioners to manipulate and analyze complex biological fluids at the nano and microliter scale. Specifically, various miniaturized diagnostic devices have been developed for blood sample detection, which can increase diagnostic capacity significantly by enabling rapid, point-of-care chemical analysis. Recently, more and more researchers are paying attention to on-chip whole blood sample pretreatment, which is the focus of this eBook, aiming to form real Micro Total Analysis Systems (uTAS) for whole blood analysis by integrating blood sample pre-treatment and detection together.

The eBook consists of six chapters. Chapter 1 gives a brief introduction on the background of whole blood and the concept of µTAS, followed by a summary of specific microfluidic chips for whole blood pretreatment. Chapter 2 firstly reviews microfluidic chips for plasma isolation from whole blood samples with various methodologies (i.e., microfiltration, microcentrifugation, ultrasound, Zweifach–Fung effect and capillary effect). Then two examples using the plasma skimming effect and crossflow filtration respectively are discussed in detail. Chapter 3 firstly reviews microfluidic devices for blood cell filtrating, sorting and collection. Sorting methods such as size filtration, optical and magnetic manipulation, affinity separation, dielectrophoretic manipulation are covered and compared. Then a case study using crossflow filtration is analyzed in detail. Chapter 4 firstly reviews reported microfluidic devices for blood cell lysis in which mechanical lysis, sonication lysis, thermal lysis, electrical lysis, chemical lysis and optical lysis are covered. And then a cell lysis microchip using chemical agents for cell lysis is chosen as an example for further concept demonstration. Chapter 5 firstly reviews microfluidic devices for DNA extraction and purification by comparing reported methods of solid phase extraction, solid phase reversible immobilization and liquid/liquid extraction. And then two microchips with different solid phase matrixes are used for demonstration of chip based DNA extraction. Chapter 6 firstly reviews current integrated microfluidic platforms for blood pretreatment, followed by a case study.

Both fundamental analysis and specific applications are presented in this eBook, which is written for researchers, engineers, and advanced students who have research interest in whole blood pretreatment and miniaturized techniques.

We would like to express our appreciation to Bentham Science Publishers and their team members.