Bentham Science Publishers

Stem cell and regenerative medicine research is a hot area of research which promises to change the face of medicine as it will be practiced in the years to come. Challenges in the 21st century to combat diseases such as tumors, Alzheimer's disease and related neurodegenerative diseases may well be addressed employing stem cell therapies and tissue regeneration. Frontiers in Stem Cell and Regenerative Medicine Research is essential reading for researchers seeking updates in stem cell therapeutics and regenerative medicine.

The second volume of this series features reviews on several key topics in this field including cardiac regeneration strategies, induced pluripotent stem cell therapeutics, stem cell therapy for peripheral nerve and cutaneous injuries, dental tissue regeneration, the potential of stem cell differentiation into ovarian cells and much more.

Stem cell and regenerative medicine research is a hot area of research which promises to change the face of medicine as it will be practiced in the years to come. Challenges in the 21st century to combat diseases such as cancer, Alzheimer and related diseases may well be addressed employing stem cell therapies and tissue regeneration. Frontiers in Stem Cell and Regenerative Medicine Research is essential reading for researchers seeking updates in stem cell therapeutics and regenerative medicine.

The fourth volume of this series features reviews on the use of stem cells through retrodifferentiation, mesodermal regeneration, hematopoiesis and mesenchymal stem cells. The volume also features a chapter on current knowledge on cell-based therapy in veterinary medicine.

Stem cell and regenerative medicine research is a hot area of research which promises to change the face of medicine as it will be practiced in the years to come. Challenges in the 21st century to combat diseases such as cancer, Alzheimer and related diseases may well be addressed employing stem cell therapies and tissue regeneration. Frontiers in Stem Cell and Regenerative Medicine Research is essential reading for researchers seeking updates in stem cell therapeutics and regenerative medicine.

The sixth volume of this series features reviews on roles of mesenchymal stem cells in cartilage regeneration and bone regeneration, liver regeneration, cardiogenesis, cardiomyocyte differentiation, and regenerative therapy for neurodegenerative disorders.

Stem cell and regenerative medicine research is a hot area of research which promises to change the face of medicine as it will be practiced in the years to come. Challenges in the 21st century to combat diseases such as cancer, Alzheimer and related diseases may well be addressed employing stem cell therapies and tissue regeneration. Frontiers in Stem Cell and Regenerative Medicine Research is essential reading for researchers seeking updates in stem cell therapeutics and regenerative medicine.

This volume includes reviews on the following topics:

-the role of microvesicles and exosomes in mesenchymal stem cell (MSCs) in treating diseases while overcoming side effects

-alternative models for understanding cancer stem cell biology

-stem cells treatments for orthopaedic injury and endocrine disorders

-wound healing biomaterials

-theoretical models of hematopoietic cell dynamics (with implications for bone marrow transplants)

Volume 1 - Frontiers on Recent Developments on Plant Science is an edited, peer-reviewed volume comprised of a collection of individual chapters from leading research groups across different continents. Due to its multidisciplinary nature, the combined experiences and expertise in plant science has an increasing importance both in agriculture and industry. This evidenced by inclusion of plant biotechnology in academic curricula from high school to undergraduate and postgraduate degree levels, and even in Ph.D. courses. Plant Biotechnology encompasses a wide range of narrow research areas such as agricultural biotechnology, industrial and environmental biotechnology, pharmacy and pharmaceutical sciences and drug development from plant sources, plant-microbe host interactions studies, biochemical and molecular studies on gene expression using various plant models, gene targeting, homologous and non-homologous recombination studies on plant models, RNAi technology in plants, cereal biotechnology, biotechnology of endangered plant species, forestry, phytoremediation technologies, genetic engineering, gene delivery approaches, plant tissue culture and biological and biochemical techniques and methods/protocols involved in different focal area of plant science.

Functional Bio-based Materials for Regenerative Medicine: From Bench to Bedside explores the use of bio-based materials for the regeneration of tissues and organs. The book presents an edited collection of 28 topics in 2 parts focused on the translation of these materials from laboratory research (the bench) to practical applications in clinical settings (the bedside). Chapter authors highlight the significance of bio-based materials, such as hydrogels, scaffolds, and nanoparticles, in promoting tissue regeneration and wound healing.

Topics included in the book include:

- the properties of bio-based materials, including biocompatibility, biodegradability, and the ability to mimic the native extracellular matrix.

- fabrication techniques and approaches for functional bio-based material design with desired characteristics like mechanical strength and porosity to promote cellular attachment, proliferation, and differentiation

- the incorporation of bioactive molecules, such as growth factors, into bio-based materials to enhance their regenerative potential.

- strategies for the controlled release of molecules to create a favorable microenvironment for tissue regeneration.

- the challenges and considerations involved in scaling up the production of bio-based materials, ensuring their safety and efficacy, and obtaining regulatory approval for clinical use

Part 2 covers advanced materials and techniques used in tissue engineering. Topics focus on advanced composite materials for 3D scaffolds and the repair of tissues in different organs such as the heart, cornea, bone and ligaments. Materials highlighted in this part include polyamide composites, electrospun nanofibers, and different bio-based hydrogels.

Functional Bio-based Materials for Regenerative Medicine: From Bench to Bedside is a valuable reference for researchers in biomedical engineering, cell biology, and regenerative medicine who want to update their knowledge on current developments in the synthesis and application of functional biomaterials.

The comprehensive information about the inverse relationship between the incidence of cancer and the consumption of natural food has impacted our understanding of the biochemical mechanisms behind cancer and its treatment. Functional Foods for Health Maintenance: Understanding their Role in Cancer Prevention is a review of pre-clinical studies unraveling the chemotherapeutic potential of phytochemicals and other food sources. The editors attempt to summarize the evidence, methods and techniques for identifying specific nutraceuticals and foods capable of interfering and reducing the risk of cancer.

The book compiles 19 edited chapters that cover the chemopreventive effects of different phytochemicals, animal and stem cell models for cancer prevention, and novel nanotechnology-based nutraceuticals. The contributors have also highlighted the techniques employed for the detection of cancer with a review on cancer biomarkers. The book is a resource for post-graduate students and researchers working in the field of nutrition, molecular biology, chemoprevention, biochemistry and pharmaceutical sciences.

The eBook discusses how the special physiology of the liver must be considered when applying functional molecular imaging in hepatology. The main topics of the eBook include the clinical and scientific use and possibilities of functional molecular imaging for investigations of hepatic blood perfusion, substrate metabolism, and biliary secretion as well as for cancer diagnostics (primary and secondary liver cancers). Functional imaging of changes in cerebral blood perfusion and metabolism in patients with liver diseases is also covered. The eBook is written by internationally renowned experts and is intended for everyone who is interested in hepatology or functional molecular imaging.

Catalysis is an area of chemical sciences which has fascinated a wide range of academicians, researchers, chemical technologists and industries throughout the world. Progress in this field has been made owing to the thrust provided by this research and commercial interest. The field of catalysis is interdisciplinary by its nature, as it requires knowledge of organic synthesis, coordination and organometallic chemistry, reaction kinetics and mechanisms, stereochemical concepts and materials science.

Fundamentals and Prospects of Catalysis highlights many important topics and sub-disciplines in catalysis by presenting 7 chapters on different but varied catalytic processes. This volume presents the following topics:

Organocatalytic Asymmetric Synthesis of Spiroacetals and Bridged Acetals

Design and Development of Bimetallic Enantioselective Salen Co Catalysts for The Hydrolytic Kinetic Resolution of Terminal Epoxides

Recent Trend in Asymmetric Heterogeneous Flow Catalysis

Ball Milling: A Green Tool in Synthetic Organic Chemistry

Recent Advances in the Developments of Enantioselective Electrophilic Fluorination Reactions via Organocatalysis

Green and Sustainable Biocatalytic Routes to Prepare Biobased Polyols as Precursors for Polyurethanes with Comparison of Existing Biobased Polyol Technology

Polymers Used as Catalysts

Catalysis: Current and Future Developments is a book series that covers theoretical, experimental and applied research on catalysis and their role in enhancing the rate of chemical reactions. The scope of topics covered by volumes in the series include heterogeneous catalysis, homogeneous catalysis, bio-catalysis, aspects of catalyst preparation, activation, aging, deactivation, rejuvenation, adsorption, synthesis and catalytic functions of new catalysts (which include novel inorganic solids and metal complexes). The series also presents reviews on surface chemistry, and commercially important model catalysts and catalytic processes.

Fundamentals of Cellular and Molecular Biology is a comprehensive textbook designed to explain the molecular mechanisms that underpin the functions and structures within living organisms. This resource focuses on improving the reader's understanding and exploration of the cellular and molecular basis of life, emphasizing the latest research findings and technological advancements. The book is structured into 18 chapters that systematically cover topics ranging from the basic structural components of cells to the complex processes of gene expression, protein synthesis, and cell signaling. It offers a detailed examination of DNA replication, repair mechanisms, and the molecular basis of genetic diseases. Additionally, the book explains the application of molecular biology in biotechnology, medicine, and environmental science, as well as advanced topics like cloning, gene therapy, and molecular diagnostics.

Key features:

- Clear explanations of complex concepts, bridging basic biology concepts with applied scientific fields

- Uses real-world examples to illustrate scientific principles

- Includes information on the latest research and technological breakthroughs.

- Glossaries and references for each chapter

- Facilitates learning with diagrams, flowcharts, and tables that summarize critical information, making complex subjects accessible.

Fundamentals of Cellular and Molecular Biology is an essential resource for students in life science courses such as biology, biochemistry, biotechnology, and medicine.

Educational technology refers to the preparation and use of electronic resources, computer applications, and audio-visual aids which are used in the teaching and learning process. For administrators, the term also includes the planning, organization validation, evaluation, and implementation of all kinds of educational programs. Educational technology is now important for the selection of appropriate teaching media as well as the development, and application of curricula. Fundamentals of Educational Technology work explains the basic facts about educational technology to inform teachers and students. The book includes 6 chapters which cover the subject in a simple manner suitable for learners in education programs. Key Features: - 6 organized chapters on the basics of educational technology and media - Simple reader-friendly organization of contents with relevant diagrams - Gives a historical perspective of the field - Gives an overview of digital and electronic tools for educators - Includes information about relevant teaching methods - Gives an overview of the role of electronic and digital media in education - Includes a section on the ethical use of educational technology Fundamentals of Educational Technology serves as a basic guide for educational instructors and administrators on educational technology and its role in teaching and designing educational programs at all levels.

Fundamentals of Mathematics in Medical Research: Theory and Cases is a comprehensive guide to the mathematical principles and methods used in medical research. This book is structured to facilitate learning and application and gives a solid foundation to readers. The book is divided into multiple parts that explain basic concepts in a progressive way.

- Part I covers real-valued functions of one or more variables with geometric representations to establish a core understanding of advanced mathematics

- Part II covers inferential methods of probability and statistics from basic probability to parametric and nonparametric tests

- Part III covers correlation theory and advanced analysis of real-valued functions

- Part IV covers multivariable analysis for solving complex problems with an explanation of Markov Chain models

- An Appendix provides solutions for all exercises and along with Fortran 90 programs, Python scripts and Linux scripts to explore the mathematical concepts explained in the book.

Key Features:

Introduction and Conclusion in Every Chapter

Exercises and Solutions

Program codes and scripts

Comprehensive Coverage of Mathematics for Academics and Research

Real-World Cases

This book is an essential resource for researchers, students, and professionals in medicine and allied fields who seek to understand and apply mathematical methods in their work.

An understanding of biological systems at cellular and molecular levels helps researchers to model cellular behavior in different experimental conditions. This, in turn, can lead to insights about the influence of cell culture environment and the effect of knockout gene research when studying mutations that affect specific metabolic pathways. A systems biology approach, therefore, allows researchers to simulate experimental observations in order to predict outcomes at the cellular level.

Fundamentals of Systems Analysis and Modeling of Biosystems and Metabolism presents the basic concepts required for a systems biology approach towards cellular modeling. The book is intended as a primer for systems biology and biomedical engineering graduates and researchers. The text introduces readers to concepts related to cellular metabolism and its regulation, (enzymatic regulation and transcriptional regulation) which are also incorporated into a main metabolic model of a cell. The book also has chapters dedicated to identifying and incorporating steady-state and dynamic characteristics when considering a biological model for a computer simulation.

Readers will be able to (1) understand the basis of systems analysis towards creating appropriate biological models and simulations, (2) develop useful kinetic models based on cellular transport phenomena and metabolic regulation, (3) understand how to simulate a cell growth phenotype, and analyze it with experimental data.

Fungal Lipid Biochemistry explores the intricate biochemistry of fungal and microbial lipids. The book focuses on recent advances in our knowledge about the distribution, classification, and biochemistry of fungal lipids. The book is divided into four sections, starting with an introduction to fungal lipids which includes definition, classification, nomenclature, and some historical aspects of fungal lipid research. This is followed by an overview of fungal lipids, and environmental and nutritional cultural conditions affecting lipid production. The second section contains four chapters that explain the metabolism of fatty acids, their biosynthetic pathways together with their storage mainly in the form of triacylglycerols. The latter includes a key description of the recently discovered lipid droplet acting as a highly specific cellular compartment for the storage of neutral lipids. The third section contains five chapters concerned with the relatively recent interpretation of other major lipid classes which include glycerophospholipids, sphingolipids, aliphatic hydrocarbons, sterols, carotenoids, and polyprenols and their occurrence and biosynthesis. The final section covers lipid metabolism during fungal development and sporulation. Key features - Extensive coverage of fungal lipid biochemistry, with a focus on recent knowledge - Includes chapters for specific lipid classes with notes on their metabolism - Gives knowledge about the role of lipids in fungal growth and development - Provides references for further reading This book is a comprehensive reference for academics, scientific researchers, and industrial scientists (in biotechnology, food science and nutritional health) who require information about fungal lipid composition and biochemistry.

This reference focuses on defined types of compounds which are of interest to readers who are motivated to explore basic information about new materials for advanced industrial applications. General and established synthetic methodologies for several compounds are explained giving a straightforward approaches for researchers who intend to pursue new projects in materials sciences, This book presents 9 chapters, covering phthalocyanines, polymethines, porphyrins, BODIPYs, dendrimers, carbon allotropes, organic frameworks, nanoparticles and future prospects. Each chapter covers detailed synthetic aspects of the most established preparation routes for the specific compounds, while giving a historical perspective, with selective information on actual and outstanding applications of each material, unraveling what likely might be the future for each category. This book is intended as a hands-on reference guide for undergraduates and graduates interested in industrial chemistry and materials science.

GIS - An Overview of Applications is a compilation of reviews that give an overview of the latest advances in Geographic Information System (GIS) technology. The multidisciplinary nature of the book gives readers perspectives in research fields as diverse as forest management, land use and cover, tourism, environment impact assessment, climate change studies, biodiversity and health care and mobility studies.

The book is a suitable reference for graduates involved in data engineering and GIS courses as well as working professionals in the field of data engineering, analysis and management.

Mucins are glycoproteins that are expressed in cells of different types and fulfill multiple functions that determine participation of these proteins in such processes as signal transduction, regulation of gene expression, cell proliferation, embryogenesis, cell differentiation, immunity, apoptosis and cancer development. This E-book series on mucins presents critical reviews on modern data concerning structures and functions of mucins, their roles in cell physiology and pathology as well as molecular aspects of therapy of mucin-associated diseases. Mucins are represented by two types of molecules: secreted mucins and membrane-bound (receptor) mucins. This e-book series represents a unique attempt to describe the molecular nature of mucin multifunctionality in separate volumes. Chapters in each volume demonstrate the central role of mucins as connectors and regulators of different signaling pathways and their participation metastatic processes. Clinical aspects of mucins, such as their role as diagnostic markers as well as possible applications in mucin-based immuno- and gene-therapies are also discussed.

This is the first volume of the series. This volume introduces readers to the general properties of mucins, followed by chapters on specific variants of gel-forming and soluble mucins. The volume concludes with information on the functions of secreted mucins.

This reference is a comprehensive review of genome editing in bacteria. The multi-part book meticulously consolidates research findings and insights on the applications of bacteria across several industries, including food processing and pharmaceutical development. The book covers four overarching themes for readers: a historical perspective of genome editing, genome editing in probiotics, applications of genome editing in agricultural microbiology and genetic engineering in environmental microbiology. The editors have also compiled chapters that provide an in-depth analysis of gene regulation and metabolic engineering through genome editing tools for specific bacteria.

Key topics in part 1:

- An Overview of advances in CRISPR-CAS research

- Applications of CRISPR/CAS9-based genome editing for industrial microorganisms

- Gut microbiome modulation to address gut dysbiosis

- Bifidobacterium genome editing for probiotic development and metabolic engineering.

- Insights into the use of lactic acid bacteria as starter cultures in the food

- Genome editing of vegetable-derived L. Plantarum

- Genome editing in Bacillus Licheniformis

Genome Editing in Bacteria is a definitive reference for scholars, researchers and industry professionals navigating the forefront of bacterial genomics.

This reference is a timely compilation of studies of genome size and genetic stability of regenerated plants. It presents 13 book chapters that cover recent advancements in CRISPR/Cas-based genome editing, the use of molecular markers to analyze somaclonal variation in tissue culture, and genetic stability assessment in various plant species, including medicinally valuable plants like Valeriana and Coffea. The book also highlights the role of flow cytometry in investigating polyploidy and provides valuable insights into genetic fidelity assessment of micropropagated woody plants and orchids. The contributors have shed light on the intra-specific and inter-specific genome and chromosome number variation with reference to gene duplication and DNA sequence loss. Molecular techniques for detecting ploidy levels and genetic homogeneity in regenerated plantlets are also discussed. Additional highlights of the book include brief guidelines for experimental protocols for flow cytometry and molecular markers, coverage of a wide range of plants, and supporting references. This is an excellent reference for biologists, geneticists, and plant scientists exploring genetic homogeneity and genome size variation in diverse plant groups.

Geriatric Anesthesia: A Practical Guide is a comprehensive reference on geriatric anesthesia. The book is divided into three sections. The first section covers the basics of both anatomical and physiological changes in senescence, and important polypharmacy considerations common in elderly patients. The next section covers anesthesia for cardiac and non-surgical patients. Various controversies and legal ethical issues that are particularly significant in the elderly such as advance directives, code status discussions, specific patient groups and shared decision-making prior to surgical interventions, are covered in the final section.

Key features

- 20 referenced chapters covering basic geriatric anesthesia considerations, cardiac and non-surgical patients and special topics, respectively

- Contributions and references from experienced anesthesiologists

- Emphasis on tailoring perioperative management depending on specific circumstances of patients

- Addresses novel and commonly overlooked topics related to the geriatric population

This book is a guide for both anesthesia providers and non-anesthesia medical providers, trainees and students. It equips them with necessary information to understand and devise anesthetic plans while being aware of postoperative complications and the respective treatment and management options.

Global Neutron Calculations provides assessment guidelines for nuclear reactors in a step-by-step manner. The book introduces readers to principal physical ideas, the fundamentals of nuclear reactors including the theory of self-sustaining chain reactions and the associated physical and mathematical calculations. The required theory, the mathematical appparatus and, the applied methods are comprehensively explained in the first half of the book followed by details about the applications of the theory and methods.

Readers will gain essential information about reactor control and surveillance, instrumentation and control, technology, fuel management, core design and the differences in reactor technologies.

Global Neutron Calculations demystifies technical and mathematical knowledge about reactor design, operation, safety and analysis for engineers learning about one of mankind’s most controversial means of power generation.

Glucose homeostasis and insulin resistance presents a broad overview of the molecular, biochemical and clinical aspects of glucose metabolism and glucose resistance. The book serves to acquaint the reader with recent information on topics ranging from the glucose metabolism and glucose transporters, the hormonal regulation of glucose homeostasis, to insulin resistance and the characterization of novel pharmacological approaches on emerging targets for the treatment of diabetes. Also included in the book is a discussion on the role of mutations in insulin resistance. The book is particularly useful for clinical researchers, endocrinologists and diabetes specialists.

Glycosylation and Glycation in Health and Diseases provides a comprehensive exploration of the essential biochemical processes, their implications in physiology, and their role in disease progression.

This book is divided into two key sections: the first focuses on glycosylation, an enzymatic process essential for cellular function, while the second covers glycation, a nonenzymatic reaction linked to aging and chronic diseases. It covers congenital glycosylation disorders, the biology of advanced glycation end products (AGEs), and the critical role of the receptor for AGEs (RAGE) in inflammatory, neurological, cardiovascular, and cancer-related conditions.

A valuable resource for students, researchers, and industry professionals, this book highlights the significance of glycobiology in drug discovery, diagnostics, and therapeutic innovations.

Key Features:

- Covers fundamental and advanced concepts of glycosylation and glycation.

- Discusses the role of glycans in cellular function and disease pathology.

- Explores AGE-RAGE interactions in cardiovascular, pulmonary, and neurological disorders.

- Highlights applications in biopharmaceuticals, diagnostics, and vaccine development.

Graphene-Based Nanomaterial Catalysis compiles knowledge about catalytic graphene-based nanomaterials in a single easy-to-read volume. The text serves to familiarize scholars and professionals with the methods of fabrication of both functionalized and non-functionalized graphene nanomaterials suitable for use in a variety of applications such as electrochemical sensors, oxygen and hydrogen production, fuel cells and organic transformations.

Key Features

- systematic chapters which present the topic in an accessible way that is targeted towards learners

- Accessible information about the fabrication of graphene-based catalysts

- updated knowledge about catalytic applications of graphene-based nanomaterials in electro- and organic catalysis.

- delivers information about recent trends in industry and research.

- covers sophisticated green technologies such as carbon dioxide conversion and solar powered water splitting

- references for further reading

Interested students in material science at undergraduate, graduate and postgraduate levels in the disciplines of chemical engineering and materials science will highly benefit from the information in this reference. The reference also gives researchers in both industry and academia an opportunity to update their knowledge of graphene-based nanomaterials useful for catalysis.

This book informs readers about recent advances in graphene carbocatalysis encapsulating the current developments in the syntheses, properties, characterizations, functionalization and catalytic applications of graphene, its derivatives and composites. It serves as a comprehensive primary reference book for chemistry and engineering students who are required to learn about graphene chemistry in detail. It also serves as an introductory reference for industry professionals and researchers who are interested in graphene research as well as its emerging applications in catalysis and beyond. Volume 1 provides an introduction to catalysis and the chemistry of graphene. This is followed by chapters that cover the chemistry of graphene compounds. Next, it covers the functionalization of graphene into catalytic materials and its role in the synthesis of nanocomposites. Finally, the book delves into the complex aspects of graphene carbocatalysis: recent advances in graphene supported palladium catalysts for coupling reactions, applications of graphene-based catalysts in multicomponent, domino reactions, oxidation and reduction reactions, and recent trends in biocatalytic properties of graphene-based composites are all discussed in detail.