Bentham Science Publishers

This reference presents information about models utilized in experimental medicine and pharmaceutical research and development for several human diseases. Written by experts in immunology, cancer biology and pharmacology, the book provides readers with handy notes and updated data on animal models that are critical to research planning and lab execution.

The main feature of the book is a set of 12 structured chapters that focus on a specific disease such as cancer, infectious diseases, autism, autoimmune diseases, Alzheimer's disease and anemia. The contributors have gathered information on a wide range of genetic and physiological animal models that are employed in research with comparative charts that highlight their main differences. The book also includes chapters for special topics like food allergies and dentistry. Additional features of the book are an explanation of disease mechanisms that give an easy understanding, notes for idiopathic models and specific clinical conditions, and a list of references for advanced readers.

Animal Models In Experimental Medicine is essential reading for scholars, graduate students and senior researchers in life sciences and clinical medicine. It also serves as a resource for professionals involved in bench-to-bedside pharmaceutical projects.

Anthocyanins are a diverse group of phytochemicals used for the treatment and management of acute and chronic ailments. This book is a comprehensive guide to anthocyanins and their importance as pharmaceutical and nutraceutical agents. The book provides detailed information about anthocyanin sources and their application in the treatment of diseases including cancer, gastric disorders, infertility, metabolic diseases, and neurological disorders.

Key features

· Explains the importance of phytochemicals and nutraceuticals

· Provides details of anthocyanin sources and mechanisms of action

· Includes chapters dedicated to the use of anthocyanins to treat specific diseases

· Provides a summary of the market for anthocyanins as a pharmaceutical and nutraceutical product

· Includes scientific references

Following the post 9/11 distribution of anthrax spores through the U.S. mail, and the resulting deaths of five individuals - primarily due to initial misdiagnosis - there has been a renewed interest in anthrax among clinicians and intelligence agencies, particularly as a biological warfare agent. This monograph brings forth essential knowledge about anthrax. Included in this volume, are, the early history, non-natural outbreaks of anthrax, characteristics of the causative organism Bacillus anthracis and its relationship to other members of the B. cereus family. Also included are reports on extensive clinical findings, mechanisms of anthrax virulence and the genetics responsible for these virulence factors. The extensive studies over the years regarding the development of veterinary and human vaccines, and molecular studies, including conventional PCR and real-time PCR are explained in comprehensive detail, with the help of tables, figures and extensive references. This eBook serves as an advanced presentation and reference work for individuals seeking detailed information regarding anthrax and as a primary guide for individuals pursuing studies on anthrax.

The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, etc. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results.

Anti-angiogenesis Drug Discovery and Development provides is an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two recent decades. The feast of these reader-friendly reviews on topics of great scientific importance – many of which are considered significant medical breakthroughs, makes this book excellent reading both for the novice as well as for expert medicinal chemists and clinicians.

The second volume of this ebook series covers topics including:

-Clear Cell Renal Cell Carcinoma as a Model of Pathological Angiogenesis

-Discovery and Development of Antiangiogenetic Drugs in Ovarian Cancer

-Anti-Angiogenic Therapy and Cardiovascular Diseases

… and more.

The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, etc. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results.

Anti-angiogenesis Drug Discovery and Development provides an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. The feast of these reader-friendly reviews on topics of great scientific importance – many of which are considered significant medical breakthroughs, makes this series excellent reading both for the novice as well as for expert medicinal chemists and clinicians.

This volume brings together 5 reviews on the following topics:

- Retinal angiogenesis

- Effects of brief daily EMF therapy on tumor growths

- Evolution of the role of angiogenesis in cancer treatments over six decades

- Anti-angiogenesis drugs

- Anti-angiogenesis therapy for multiple sclerosis

- Update on the link between angiogenesis and portal hypertension

Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric illnesses. Onset of obesity in both the developing and the developed world has reached epidemic proportions. In response to this, efforts to control and treat obesity have also been vigorously pursued, ranging from raising awareness about lifestyle changes to the discovery and development of safe and effective anti-obesity drugs.

Anti-obesity Drug Discovery and Development is focused on this very important area of healthcare research. Fifteen well written reviews make this special volume an excellent compilation of recent developments in anti-obesity treatment. The reviews cover a variety of topics including the development of specific, safe and effective receptor antagonists, the role of epithelial endocrine cells and post operative treatment strategies. This book should be useful to clinicians and medicinal chemists involved in ant-obesity research and therapy.

Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric illnesses. Onset of obesity in both the developing and the developed world has reached epidemic proportions. In response to this, efforts to control and treat obesity have also been vigorously pursued, ranging from raising awareness about lifestyle changes to the discovery and development of safe and effective anti-obesity drugs.

Anti-obesity Drug Discovery and Development is focused on this very important area of healthcare research. The third volume of this series is dedicated to anti-obesity treatments including updates on new therapeutics for obesity, Nesfatin-1 and its therapeutic uses, the role of proteomics in pediatric anti-obesity treatment, the role of oxidative stress in childhood obesity and a review of data on gut microbiota as a treatment option for obesity.

Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric illnesses. The incidence of obesity among populations in both the developing and the developed world has reached epidemic proportions. In response to this, efforts to control and treat obesity have also been vigorously pursued, ranging from activities focused on raising awareness about lifestyle changes to the discovery and development of safe and effective anti-obesity drugs. Anti-obesity Drug Discovery and Development is a book series focused on this very important area of healthcare research. Each volume presents insightful updates on pharmaceutical research and development for clinical researchers and healthcare professionals involved in obesity treatment programs.

The fifth volume of this series is a compilation of 6 reviews of interesting topics on the subject that highlight different aspects of obesity treatment and management, some of which are novel approaches. Topics covered in this volume include:

- the effect of sleep on weight and obesity management

- AMPK as a postulated target for metabolic syndrome and obesity

- Harnessing addiction neuroscience to treat obesity

- Current treatment of obesity versus the next generation of anti-obesogenic drugs: an ecologically and sustainable approach to health

- Leptin and leptin sensitizers for the treatment of obesity related conditions

- MicroRNAs as targets for the management of obesity