Bentham Science Publishers

This reference presents information about models utilized in experimental medicine and pharmaceutical research and development for several human diseases. Written by experts in immunology, cancer biology and pharmacology, the book provides readers with handy notes and updated data on animal models that are critical to research planning and lab execution.

The main feature of the book is a set of 12 structured chapters that focus on a specific disease such as cancer, infectious diseases, autism, autoimmune diseases, Alzheimer's disease and anemia. The contributors have gathered information on a wide range of genetic and physiological animal models that are employed in research with comparative charts that highlight their main differences. The book also includes chapters for special topics like food allergies and dentistry. Additional features of the book are an explanation of disease mechanisms that give an easy understanding, notes for idiopathic models and specific clinical conditions, and a list of references for advanced readers.

Animal Models In Experimental Medicine is essential reading for scholars, graduate students and senior researchers in life sciences and clinical medicine. It also serves as a resource for professionals involved in bench-to-bedside pharmaceutical projects.

Anthocyanins are a diverse group of phytochemicals used for the treatment and management of acute and chronic ailments. This book is a comprehensive guide to anthocyanins and their importance as pharmaceutical and nutraceutical agents. The book provides detailed information about anthocyanin sources and their application in the treatment of diseases including cancer, gastric disorders, infertility, metabolic diseases, and neurological disorders.

Key features

· Explains the importance of phytochemicals and nutraceuticals

· Provides details of anthocyanin sources and mechanisms of action

· Includes chapters dedicated to the use of anthocyanins to treat specific diseases

· Provides a summary of the market for anthocyanins as a pharmaceutical and nutraceutical product

· Includes scientific references

Following the post 9/11 distribution of anthrax spores through the U.S. mail, and the resulting deaths of five individuals - primarily due to initial misdiagnosis - there has been a renewed interest in anthrax among clinicians and intelligence agencies, particularly as a biological warfare agent. This monograph brings forth essential knowledge about anthrax. Included in this volume, are, the early history, non-natural outbreaks of anthrax, characteristics of the causative organism Bacillus anthracis and its relationship to other members of the B. cereus family. Also included are reports on extensive clinical findings, mechanisms of anthrax virulence and the genetics responsible for these virulence factors. The extensive studies over the years regarding the development of veterinary and human vaccines, and molecular studies, including conventional PCR and real-time PCR are explained in comprehensive detail, with the help of tables, figures and extensive references. This eBook serves as an advanced presentation and reference work for individuals seeking detailed information regarding anthrax and as a primary guide for individuals pursuing studies on anthrax.

The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, etc. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results.

Anti-angiogenesis Drug Discovery and Development provides is an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two recent decades. The feast of these reader-friendly reviews on topics of great scientific importance – many of which are considered significant medical breakthroughs, makes this book excellent reading both for the novice as well as for expert medicinal chemists and clinicians.

The second volume of this ebook series covers topics including:

-Clear Cell Renal Cell Carcinoma as a Model of Pathological Angiogenesis

-Discovery and Development of Antiangiogenetic Drugs in Ovarian Cancer

-Anti-Angiogenic Therapy and Cardiovascular Diseases

… and more.

The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, etc. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results.

Anti-angiogenesis Drug Discovery and Development provides an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. The feast of these reader-friendly reviews on topics of great scientific importance – many of which are considered significant medical breakthroughs, makes this series excellent reading both for the novice as well as for expert medicinal chemists and clinicians.

This volume brings together 5 reviews on the following topics:

- Retinal angiogenesis

- Effects of brief daily EMF therapy on tumor growths

- Evolution of the role of angiogenesis in cancer treatments over six decades

- Anti-angiogenesis drugs

- Anti-angiogenesis therapy for multiple sclerosis

- Update on the link between angiogenesis and portal hypertension

Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric illnesses. Onset of obesity in both the developing and the developed world has reached epidemic proportions. In response to this, efforts to control and treat obesity have also been vigorously pursued, ranging from raising awareness about lifestyle changes to the discovery and development of safe and effective anti-obesity drugs.

Anti-obesity Drug Discovery and Development is focused on this very important area of healthcare research. Fifteen well written reviews make this special volume an excellent compilation of recent developments in anti-obesity treatment. The reviews cover a variety of topics including the development of specific, safe and effective receptor antagonists, the role of epithelial endocrine cells and post operative treatment strategies. This book should be useful to clinicians and medicinal chemists involved in ant-obesity research and therapy.

Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric illnesses. Onset of obesity in both the developing and the developed world has reached epidemic proportions. In response to this, efforts to control and treat obesity have also been vigorously pursued, ranging from raising awareness about lifestyle changes to the discovery and development of safe and effective anti-obesity drugs.

Anti-obesity Drug Discovery and Development is focused on this very important area of healthcare research. The third volume of this series is dedicated to anti-obesity treatments including updates on new therapeutics for obesity, Nesfatin-1 and its therapeutic uses, the role of proteomics in pediatric anti-obesity treatment, the role of oxidative stress in childhood obesity and a review of data on gut microbiota as a treatment option for obesity.

Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric illnesses. The incidence of obesity among populations in both the developing and the developed world has reached epidemic proportions. In response to this, efforts to control and treat obesity have also been vigorously pursued, ranging from activities focused on raising awareness about lifestyle changes to the discovery and development of safe and effective anti-obesity drugs. Anti-obesity Drug Discovery and Development is a book series focused on this very important area of healthcare research. Each volume presents insightful updates on pharmaceutical research and development for clinical researchers and healthcare professionals involved in obesity treatment programs.

The fifth volume of this series is a compilation of 6 reviews of interesting topics on the subject that highlight different aspects of obesity treatment and management, some of which are novel approaches. Topics covered in this volume include:

- the effect of sleep on weight and obesity management

- AMPK as a postulated target for metabolic syndrome and obesity

- Harnessing addiction neuroscience to treat obesity

- Current treatment of obesity versus the next generation of anti-obesogenic drugs: an ecologically and sustainable approach to health

- Leptin and leptin sensitizers for the treatment of obesity related conditions

- MicroRNAs as targets for the management of obesity

This handbook focuses on the use of antibiotic alternatives in poultry and fish feed. Chapters in the book cover a range of natural ingredients in feed and the impacts of these natural feed additives on growth, production, reproduction and health status of poultry and fish. All chapters give a holistic approach to how organic feed additives (herbal plants and their extracts, probiotics, peptides, etc.) can positively impact animal health and production.

Key Features:

- presents 13 chapters contributed by 38 experts and scientists of animal, poultry and fish nutrition, poultry and fish physiology, toxicology, pharmacology, and pathology

- highlights the significance of herbal plants and their extracts and derivatives, cold-pressed and essential oils and fruits by-products

- covers the effects of special ingredients such as immunomodulators, antimicrobial peptides, and probiotics

- provides the reader an updated perspective on the use of additives in poultry and fish industry as growth promoters and their role in developing bacterial resistance to antibiotics

- covers the main poultry species, egg-laying hens, quails, geese, ducks, turkey, and commercial fish

- includes references for advanced readers

This book will be useful for poultry and fish keepers and researchers in animal nutrition, pharmacology, and veterinary sciences. Professionals involved in the poultry and fish feed industry will also find the information useful for product development.

Antibodies Applications and New Developments is an overview of the current developments of techniques and methods relating to immunodiagnostics and immunoanalysis. This eBook also deals with specialties in the fields of drug, pesticide, antigen and food contaminant detection. The volume is useful for professional immunologists and biotechnologists interested in antibody research and development.

Probiotics have been suggested to be involved in both prevention and treatment of various human cancers. Anticancer Immunity: Reviewing the Potential of Probiotics explains biochemical mechanisms of anticancer immunity exerted by probiotics in various human cancers. It presents edited chapters focused on the evidence of probiotic use against human cancers through several animal and human studies. This volume consists of 11 chapters. The volume continues from the previous entry with chapters focused on probiotics' anticancer immunity in specific cancers such as, bladder cancer, renal cell carcinoma, prostate cancer, lymphomas, pancreatic cancer, oral cancer and oropharyngeal cancers. The book concludes with chapters that inform readers about the value of prebiotics, postbiotics and postbiotics in cancer therapy as adjuvants and immunotherapeutic agents. Key features - Gives a new dimension and insight in the role of probiotics in anticancer immunity towards various human cancers - Provides several color figures and tables to clearly explain relevant information. - Includes recent information with new insights and references - Meets the needs of basic (pre-clinical) and advanced clinical researchers and postgraduate scholars

The book covers the applications of some alternative approaches for prolonging food shelf life. The book describes the role of food safety objectives, natural compounds (such as oils and microbial enzymes), pressure and atmospheric techniques and alternative approaches (microwave, irradiation and mathematical microbial modeling) in food preservation.

Implications of preservative approaches on food texture and sensorial quality are also discussed along with technology related hurdles commonly encountered in the field. The book should be very useful for food producers and microbiologists.

This book provides a thorough investigation of the application of chaos theory and fractal analysis to computer vision. The field of chaos theory has been studied in dynamical physical systems, and has been very successful in providing computational models for very complex problems ranging from weather systems to neural pathway signal propagation. Computer vision researchers have derived motivation for their algorithms from biology and physics for many years as witnessed by the optical flow algorithm, the oscillator model underlying graphical cuts and of course neural networks. These algorithms are very helpful for a broad range of computer vision problems like motion segmentation, texture analysis and change detection.

The contents of this book include chapters in biological vision systems, foundations of chaos and fractals, behavior of images and image sequences in phase space, mathematical measures for analyzing phase space, applications to pre-attentive vision and applications to post-attentive vision.

This book is intended for graduate students, upper division undergraduates, researchers and practitioners in image processing and computer vision. The readers will develop a solid understanding of the concepts of chaos theory and their application to computer vision. Readers will be introduced to a new way of thinking about computer vision problems from the perspective of complex dynamical systems. This new approach will provide them a deeper understanding of the various phenomena present in complex image scenes.

This book is a guide to the application of ionic liquids (ILs) in the oil industry. It includes ten chapters that review basic and advanced topics. Starting with a general introduction to IL structure and properties, the book comprehensively explains the use of ILs in key petroleum extraction processes such as pollutant removal, demulsification, crude oil transport and oil recovery. Additional applications that are important for the sustainability management of petrochemical operations such as deepwell hydrate inhibition, CO2 capture, corrosion engineering, catalysis, hydrocarbon separation, bitumen extraction and stabilization are also included. Each chapter also provides bibliographic references for further reading. The wide range of topics makes this an informative reference to students and professionals in petroleum engineering, chemical engineering programs and any other training course that requires reading material for an understanding of the oil industry. General readers and researchers interested in the fascinating chemistry of ionic liquids will also enjoy this book.

Applications of Modern Mass Spectrometry, Volume 2, covers the latest advances in mass spectrometry in scientific research. The series presents readers with information on the broad range of mass spectrometry techniques and configurations, data analysis, and practical applications. Each volume contains contributions from eminent researchers who present their findings in an easy-to-read format. The multidisciplinary nature of the works presented in each volume of this book series makes it a valuable reference on mass spectrometry to academic researchers and industrial R&D specialists in applied sciences, biochemistry, life sciences, and allied fields.

The second volume of the series presents 6 reviews: Ion Mobility-Mass Spectrometry for Macromolecule Analysis - Recent Advancements in Detection of Organic Contaminants in Wastewater Using Advanced Mass Spectrometry - Poisonous Substances in Tropical Medicinal and Edible Plants: Traditional Uses, Toxicology, and Characterization by Hyphenated Mass Spectrometry Techniques - LC-MS Analysis of Endogenous Neuropeptides from Tissues of Central Nervous System: An Overview - Advances in Structural Proteomics Using Mass Spectrometry and Recent Trends of Modern Mass Spectrometry: Application towards Drug Discovery and Development Process.

Applications of NMR Spectroscopy is an eBook series devoted to publishing the latest advances in the application of nuclear magnetic resonance (NMR) spectroscopy in practical situations. The second volume of this eBook series features five chapters covering NMR spectroscopic analysis of plant polyphenols, the role of NMR spectroscopy in neuroradiology, NMR –based sensors, studies on protein and nucleic acid structure and function, and mathematical formations for NMR spectroscopy in structural biology.

Applications of NMR Spectroscopy is a book series devoted to publishing the latest advances in the applications of nuclear magnetic resonance (NMR) spectroscopy in various fields of organic chemistry, biochemistry, health and agriculture.

The fourth volume of the series features several reviews focusing on NMR spectroscopic techniques in food sciences. Readers will find references on methods used to test food quality, food color analysis, the role of Tannins in wine taste as well as NMR studies on lipid oxidation and large protein complexes.

Applications of NMR Spectroscopy is a book series devoted to publishing the latest advances in the applications of nuclear magnetic resonance (NMR) spectroscopy in various fields of organic chemistry, biochemistry, health and agriculture.

The sixth volume of the series features reviews focusing on NMR spectroscopic techniques for studying tautomerism, applications in medical diagnosis, in food chemistry and identifying secondary metabolites.

Applications of NMR Spectroscopy is a book series devoted to publishing the latest advances in the applications of nuclear magnetic resonance (NMR) spectroscopy in various fields of organic chemistry, biochemistry, health and agriculture.

The eighth volume of the series features six reviews focusing on NMR spectroscopic techniques in food science, molecular biology and medical diagnosis. The reviews in this volume are:

- qNMR as a Tool for Determination of Six Common Sugars in Foods

- Correlation of VIP Scores and 1H NMR to Extract Information of Psychological Attention Tests Applied Before and After Coffee Intake

- NMR Spectroscopy for Probing the Structural Determinants of Aptamer Optimization and Riboswitch Engineering

- Applications of NMR Spectroscopy in Medical Diagnosis

- Applications of NMR Spectroscopy in Cancer Diagnosis

- NMR as a Tool for Exploring Protein Interactions and Dynamics

This volume describes recent advancements in the synthesis and applications of nanomaterials for energy harvesting and storage, and optoelectronics technology for next-generation devices.

This book consists of 15 chapters that cover a range of nanomaterials and the corresponding technologies.

The initial chapters summarize the recent progress in applications of nanomaterials like carbon nanotubes, metal oxides, and graphene oxides-based hybrids in solar energy harvesting using recent photovoltaic technologies. These chapters are followed by reviews on nanowires, graphene quantum dots, boron nitrides, carbon nano onions and metal organic frameworks leading to the fabrication of supercapacitors, bio-sensors, lithium-ion batteries and hydrogen storage applications. The final set of chapters cover the next generation fuel cells using polymer nanocomposites, ferroelectric liquid crystal nanocomposite and optoelectronic nanomaterials for optical memory and displays devices.

Key Features:

Describes the types of nanomaterials that are fundamental to energy storage and electronic systems. These materials include nanowires, graphene quantum dots, boron nitrides, carbon nano onions and metal organic frameworks (MOFs),

Covers the processes for nanomaterial synthesis

Reviews important photovoltaics applications of nanomaterials, including their use in energy storage, batteries and optoelectronic devices

Discusses the application of nanomaterials in electronics for sensing, bioelectronics, memory, nanocomposites for fuel cells, ferroelectric liquid crystal nanocomposites and optoelectronic nanomaterials for optical memory and displays

Provides references for further reading in every chapter The volume informs engineers, academic researchers, research scholars and graduate students working in the area of nanomaterials for energy generation, storage and optoelectronics.

Applications of Nanoparticles in Drug Delivery and Therapeutics is an authoritative review on nanoparticle-based drug delivery systems. This comprehensive volume focuses on the transformative role of nanoparticles in enhancing drug delivery systems and advancing therapeutic applications. By bridging the gap between laboratory research and clinical practice, this book offers a thorough exploration of how nanotechnology is revolutionizing the pharmaceutical industry.

The book is structured into well-organized chapters, each dedicated to a specific aspect of nanoparticle-based drug delivery and therapy. Initial chapters provide a foundational understanding of nanoparticle synthesis, characterization, and functionalization. Subsequent sections cover various types of nanoparticles, including liposomes, dendrimers, and polymeric nanoparticles, highlighting their unique properties and applications. The latter chapters delve into case studies and clinical trials, showcasing real-world applications and the therapeutic potential of nanoparticle technologies in treating diseases like cancer, cardiovascular disorders, and neurodegenerative diseases.

Key features of this book include detailed discussions on the design and optimization of nanoparticles for targeted drug delivery, insights into the regulatory and safety aspects of nanomedicine, and comprehensive reviews of current and emerging therapeutic applications. The book also offers practical guidance on the challenges and future directions in the field, making it an invaluable reference for researchers and practitioners alike.

Chapters 1 and 2 are based on the introduction of nanomaterials used as drug delivery systems, their manufacturing approaches and applications. Chapters 3 and 4 emphasize on the use of nanoparticles in medical diagnostics and in intervention devices. Chapters 5 and 6 illustrate the use of lipids-based nanoparticles in medical imaging and drug delivery. Chapter 7 specifically discusses amino acid functionalized inorganic nanoparticles in diagnostics. Chapter 8 is focused on the special class of nanoparticles “hybrid nanocomposites”. Chapters 9 and 10 covers the applications of silica and fullerene nanomaterials in anticancer drug delivery.

The book is intended as a resource for pharmaceutical scientists, biomedical researchers, and healthcare professionals keen on the latest advancements in drug delivery systems. It also serves as essential reading for graduate students and academics in pharmacology and medical courses that require learning about modern drug delivery systems.

The chemistry of heterocomplex compounds is a fascinating field for experts in chemical synthesis and structural analysis, and for technologists specializing in leather processing. This volume describes the vast theoretical and practical possibilities of exploiting the action synergism of metals with different collagen cross-linking capacity. The possibility of reducing chromium content from leather tanning agents by replacing it with other tanning metals has significant environmental implications and minimum changes in terms of quality and production costs of natural leather, and is a viable alternative for a safe future. Applicative Chemistry of Tanning Metallic Heterocomplexes is a book dedicated to the synthesis and use of tanning metallic heterocomplexes in leather tanning as alternatives to tanning with basic chromium salts. Replacing chromium with other tanning metals is an innovative approach that exploits the possibility that a series of known disadvantages of tanning metals used individually be reduced by heterocomplexation. The synthesis mechanism of stable combinations of chromium with other tanning metals: aluminum, iron, titanium, or zirconium is based on the stoichiometry of oxidation-reduction reactions which enables a wide range of combinations, the premise for obtaining various properties by tanning and retanning natural leather. The volume is intended as a useful reference for researchers, chemical auxiliary producers, experts in natural leather processing who are looking for clean and efficient solutions for wastewater pollutants, sludge or solid wastes while striving to preserve the known characteristics of mineral tanned natural leather.