Bentham Science Publishers

Topological geometrodynamics (TGD) is a modification of the theory of general relativity inspired by the problems related to the definition of inertial and gravitational energies in the earlier hypotheses. TGD is also a generalization of super string models. TGD brings forth an elegant theoretical projection of reality and builds upon the work by renowned scientists (Wheeler, Feynman, Penrose, Einstein, Josephson to name a few).

In TGD, Physical space-time planes are visualized as four-dimensional surfaces in a certain 8-dimensional space (H). The choice of H is fixed by symmetries of standard model and leads to a geometric mapping of known classical fields and elementary particle numbers. TGD differs from Einstein's geometrodynamics in the way space-time planes or ‘sheets' are lumped together. Extending the theory based on fusing number concepts implies a further generalisation of the space-time concept allowing the identification of space-time correlates of cognition and intentionality.

Additionally, zero energy ontology forces an extension of quantum measurement theory to a theory of consciousness and a hierarchy of phases is identified. Dark matter is thus predicted with far reaching implications for the understanding of consciousness and living systems. Therefore, it sets a solid foundation for modeling our universe in geometric terms.

Topological Geometrodynamics: An Overview explains basic and advanced concepts about TGD. The book covers introductory information and classical TGD concepts before delving into twistor-space theory, particle physics, infinite-dimensional spinor geometry, generalized number theory, Planck constants, and the applications of TGD theory in research. The book is a valuable guide to TDG theory for researchers and advanced graduates in theoretical physics and cosmology.

Cells are the building blocks of life and some cells (stem cells) have the ability to produce other cells through the processes of cell division and cell differentiation. Stem cell research has now progressed dramatically and there are countless studies published every year in scientific journals. Stem cell technology is being used to create new cell lines with edited genes and to regenerate cell based tissues for biological and medical purposes.

This ebook presents a brief snapshot of clinical research in stem cell research and regenerative medicine. The concise reference is intended to be an introduction for biology students to current standards and new technologies in these fields.

The number of transistors in integrated circuits doubles every two years, as stipulated by Moore’s law, and this has been the driving force for the huge development of the microelectronics industry in the past 50 years – currently advanced to the nanometric scale.

This e-book is dedicated to electronic noises and parasites, accounting for issues involving substrate coupling and interconnections, in the perspective of the 3D integration: a second track for enhancing integration, also compatible with Moore’s law. This reference explains the modeling of 3D circuits without delving into the latest advances, but highlights crucial problems, for instance electro-thermo-mechanical problems, which could be addressed through 3D modeling. The book also explains electromagnetic interferences , at different modeling levels (device and circuit) oriented towards 3D integration technologies. It also covers substrate noise, such as disturbances of digital blocks, power bounces, phase noise in oscillators, both at the device level, such as carriers or field fluctuations, and circuit levels. The entanglement between interconnect and substrate is also discussed.

This e-book serves as a reference for advanced graduates or researchers in the field of micro and nano electronics interested in topics relevant to electromagnetic interference or the ‘noise’ domain, at device or circuit and system levels

With the application of the effective stress concept, the strength and volumetric behavior of saturated materials was clearly understood. For the case of unsaturated materials, a universally accepted effective stresses equation is still under debate. However, the use of the effective stress concept to develop constitutive models for unsaturated soils is becoming increasingly popular not only because the hydro-mechanical coupling observed in these materials is implicit in the formulation but also because simpler and more precise models can be established. Towards A Unified Soil Mechanics Theory demonstrates that the same strength and volume change equations used in saturated soil mechanics can be used for the case of unsaturated soils. In other words, the constitutive models developed for saturated soils can be used for unsaturated materials once the effective stress equation has been defined.

In this book, an analytical equation for the effective stress for unsaturated soils is established. This equation requires the knowledge of the superficial area of solids affected by the capillary phenomenon. In other words, we need to know how water distributes in the pores of the soil. This distribution can be modeled using a solid-porous model built on a regular network. However the size of the network required to correctly simulate the structure of a small soil sample cannot be managed with a common PC. For that reason, a probabilistic porous-solid model is developed. This model uses the pore size distribution in the form of a probabilistic function which in addition to the Laplace equation and the principle of continuity can be expressed as the probability of a pore of certain size to be filled or dry at suction during a wetting or drying path, respectively. In this way, the soil-water retention curves can be simulated and the effective stress at any suction during wetting or drying processes can be determined. Based on this approach, it is shown that unsaturated soils behave under the same principles for strength and volumetric behavior as saturated soils.

Towards A Unified Soil Mechanics Theory paves the way for a universal theory of soil mechanics. The volume will be a valuable reference to civil engineers, earth scientists and hydrologists interested in soil mechanics at both academic and professional levels.

Pesticide control involves killing pest organisms or otherwise preventing them from destructive behavior. Pesticides are either natural or synthetic and are applied to target pests in a myriad of formulations (EC,WP, SP, FP, G etc.) and application technology systems (sprays, baits, slow-release diffusion, dust, etc.). In recent years, the bacterial genes coding for insecticidal proteins have been incorporated into various crops that dealt with the mortality of the pests feeding on them. Many other eco-friendly methods for insect pest control such as Integrated Pest Management (IPM), use of bio-pesticides etc., are becoming popular. Bio-pesticides and IPM should show good growth in the future, as there is growing concern for the eco-friendly organic agriculture and could be achieved through Good Agriculture Practices (GAP).

Use of pesticides requires a proper understanding of the chemistry, their handling and their use in crop protection or hygiene. These are toxic chemicals and require a good understanding of therapy and antidotes at the time of poisoning. This e-book covers pesticide chemistry, metabolic/degradation pathways, biochemical toxicology, therapy and antidotes, nano-pesticides and terminologies associated with pesticide toxicology. The book should serve as a text book for academia, or as a reference work for agriculturists, environmentalists and industry professionals.

This book serves as a treatise on lesser known ethnic varieties of cheese made in regions ranging from Mesopotamia to Europe and America. Cheese experts from different countries including Brazil, Croatia, Iran, Macedonia, Montenegro and Turkey bring together a rich blend of information about the traditional cheese in each region. The contributors describe the chemical and microbial characteristics, production technology and artisan culture of cheese making for each local variety.

The simple and systematic presentation of the information makes this a useful reference for a wide readership interested in food, dairy technology, and gastronomy, such as producers, consumers, academics and students. The book also represents an effort to bring forth knowledge about a culinary facet of the concrete cultural heritage of local communities which can benefit tourism and sustainability programs that involve the promotion of traditional dairy products.

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Current Developments in Food and Nutrition Research is a reference series intended for a multidisciplinary readership (researchers, students, and general readers) interested in subjects ranging from food science and technology to nutritional biochemistry and gastronomy.

Traditional Medicine in North East Africa: Research on Traditional Healer Preparations and Herbs explores the rich tapestry of traditional healing practices in North East Africa. This comprehensive work compiles the profound knowledge of indigenous herbalists and explores the intricate relationship between traditional healing and medicinal plants.

From combating diseases like cancer and diabetes to managing snakebites and obesity-related conditions, each chapter offers a detailed examination of plant-based remedies. Highlighting the contributions of plants like Moringa oleifera and Citrullus colocynthis, this book bridges the gap between ancient wisdom and modern research, making it essential for academics, researchers, and anyone interested in the healing powers of nature. Join us on this enlightening journey as we celebrate cultural diversity and uncover the enduring legacy of traditional medicine.

Key Features:

- In-depth studies on bioactive compounds and therapeutic properties of key African plants.

- Ethnobotanical insights into traditional healer practices.

- Comprehensive reviews linking traditional plant use to modern medical applications.

The main theme of this book is to critically survey the role of two recognized protein molecules (i.e., transcription factors) in processes of human memory. In addition, authors provided recent data from their own labs and provided a perspective relevant to specific neurological diseases and potential drug targets. Historically, the transcription factor cAMP response element-binding (CREB) has been the most well documented transcription factor shown to play a role in memory. CREB has several functions, but its most notable function has to do with the formation of long-term memories. More recently, other transcription factors, such as C/EBP, Egr protein, AP-1, and NF-κB have been implicated in memory as well. Of these, scientific literature on NF-κB's theorized role in synaptic plasticity and memory is growing rapidly. Interestingly, in some recent studies CREB and NF-κB have also been shown to interact with each other where both contribute in a cooperative fashion to the initiation of gene expression.

Advancing Intelligence: Exploring Smart Systems and Future Innovations with Machine Learning is a comprehensive volume collection examining how Artificial Intelligence (AI) and Machine Learning (ML) are reshaping industries, societies, and technologies worldwide. Written by global experts, the series combines theoretical foundations with practical applications, showcasing how intelligent systems address pressing challenges across healthcare, agriculture, urban development, business intelligence, and cybersecurity.

Volume 2: Transformative Healthcare Solutions Powered by AI & ML investigates intelligent tools for precision medicine, medical informatics, wearable devices, and patient-centric care, demonstrating how AI enhances diagnosis and treatment outcomes.

Volume 3: AI and ML Solutions Driving Modern Farming and Urban Innovation explores sustainable farming, smart agriculture, environmental monitoring, and intelligent city infrastructures for improved quality of life.

Volume 4: AI-Driven Competitive Intelligence and Next-Generation Security focuses on financial analytics, business intelligence, cybersecurity, and digital forensics, emphasizing strategies for resilience in a data-driven era.

Key Features

Integrates AI and ML into healthcare, agriculture, urban, and business systems.

Applies intelligent tools to improve diagnosis, sustainability, efficiency, and security.

Analyzes case studies and global perspectives for real-world relevance.

Explores future-ready innovations shaping intelligent, resilient ecosystems.

Addresses both societal opportunities and technical challenges of AI adoption.

Animal models of diseases play a pivotal role in drug discovery and development, not only for proof of the concept studies of efficacy, PK/PD relationship but also for drug safety assessment. Since considerable differences in variables exist between animal models and human models (such as genetics, physiology, anatomy, gene expression, heterogeneity of disease conditions, etc.), not all the preclinical models are able to represent the pathophysiological conditions in human diseases. Therefore, partly due to the lack of congruency between animal and human disease models, several proposed therapeutic agents in the past decades have been demonstrated to be effective in preclinical models but failed in clinical studies. This e-book focuses on animal models of diseases from a translational perspective and highlights the key advantages and limitations of each model described to facilitate drug discovery and development. A unique feature of the volume is that it contains a selection of details disease models in various therapeutic niches with significant unmet medical needs, including inflammation, neurological diseases, cardiovascular and metabolic diseases, and oncology.

This e-book is, therefore, of considerable value to researchers and clinicians involved in drug discovery and development as well as pathology.

This e-book presents recent advances in research in the field of particulate systems. A comprehensive background on operations involving particulate materials with a didactic approach is illustrated. Fundamentals and applications in a variety of multi-phase flow reactors are explained with a clear focus on the analysis of transport phenomena, experimental techniques and modeling. The volume spans 10 chapters covering different aspects of transport phenomena including fixed and fluidized systems, spouted beds, electrochemical and wastewater treatment reactors. This e-book will be valuable for students, engineers and researchers aiming to keep updated on the latest developments on particulate systems.

Trauma-informed care is designed to assist persons who have experienced adversity and focuses on change at the clinical and organizational level. Its goals center around prevention, intervention, and treatments that are evidence-based, encourage resilience, and enhance coping.

This textbook is designed to give a comprehensive overview of trauma-informed care to students and faculty involved in nursing care programs.

Key features:

· Explains the skill sets to assess and care for persons who have experienced trauma.

· Emphasizes key principles of trauma-informed care

· Includes the use of client-centered, person-centered, and resilience-based tools to deal with trauma

· Recommends trauma recovery from a positive psychology and post-traumatic growth perspective

· Utilizes a caring pedagogy intended to foster resilience and help offset the secondary traumatic stress and compassion fatigue experienced by student and practicing nurses.

· Communicates the value of fostering psychological safety, compassion satisfaction, and joy in work

· Includes narrative case studies and learning activities in all chapters to help the reader to actively engage with the subject matter.

· Presents self-care strategies to enhance physical and emotional well-being.

This reference explains hybrid-Trefftz finite element method (FEM). Readers are introduced to the basic concepts and general element formulations of the method. This is followed by topics on non-homogeneous parabolic problems, thermal analysis of composites, and heat conduction in nonlinear functionally graded materials. A brief summary of the fundamental solution based-FEM is also presented followed by a discussion on axisymmetric potential problems and the rotordynamic response of tapered composites. The book is rounded by chapters that cover the n-sided polygonal hybrid finite elements and analysis of piezoelectric materials.

Key Features

- Systematic presentation of 9 topics

- Covers FEMs in two sections: 1) hybrid-Trefftz method and 2) fundamental FEM solutions

- Bibliographic references

- Includes solutions to problems in the numerical analysis of different material types

- Includes solutions to some problems encountered in civil engineering (seepage, heat transfer, etc).

This reference is suitable for scholars involved in advanced courses in mathematics and engineering (civil engineering/materials engineering). Professionals involved in developing analytical tools for materials and construction testing can also benefit from the methods presented in the book.

Fish and other seafood have always been considered as an important part of human diet and have also long been recognized as a health-promoting food for human nutrition. However, managing aquatic food resources remains a challenge as the human population is expanding and overfishing poses a threat to fishing reserves in several areas. Aquaculture is the alternative solution for food production from the sea. According to the FAO, aquaculture is probably the fastest growing food-producing sector and can be a sustainable solution for fish production. In order to maximize marine food production and achieving sustainable management of the aquatic environment, knowledge about aspects of fisheries and aquatic animal health is very important.

Trends in Fisheries and Aquatic Animal Health covers some basic and applied topics in fishery management and fish health with a focus on European regions. The textbook is a combination of reviews and research articles. Topics covered in the book include challenges in fishery management, environmental impacts on fisheries, fish health (pharmacology, histopathology, stress response), telemetry techniques in fisheries research, and specific case studies of regional marine species in localized fisheries. This textbook is a useful resource for graduates and professionals involved in advanced training courses for aquaculture and fishery management.

This ebook is a collection of cutting edge articles from the 2009 Workshop on Microcavities and their Applications (WOMA 2009). It gives readers an overview of state-of-the-art opto electronic research on nano and micro cavities presented by leading experts in the field. Two major themes covered in this ebook are (i) wave- and ray-chaos in open microcavity systems and (ii) opto-electronic applications in nano and micro cavities. The book concludes with a description of recent advances in 2D whispering-gallery-mode microresonators. This ebook should be a very useful reference for any serious opto-electronics researcher.

Despite the high impact on human health caused by Tuberculosis (TB) infections worldwide, nearly 45 years have passed since a novel drug was introduced for its treatment. As MDR-TB and XDR-TB cases rise globally new strategies and drugs are desperately needed to address this problem. Tuberculosis Treatment: The Search For New Drugs covers a wide range of topics about TB drug discovery. The e-book begins with historical information about Tuberculosis discovery and treatment and explores modern treatment strategies, formulations (synthetic and natural) and class of compounds. The extraction of important drugs from various sources is also covered in separate chapters along with information about promising drugs undergoing clinical testing. The e-book is a useful reference for readers interested in learning about the array of pharmaceuticals discovered and used to combat Mycobacterium tuberculosis infections.

Turbulent Flow and Boundary Layer Theory: Selected Topics and Solved Problems explains fundamental concepts of turbulent flow with boundary layer analysis. A general introduction to turbulent flow familiarizes the reader with the mechanics of turbulence in fluid flow in both nature and engineering applications. The book also explains related concepts including transient flow, methods for controlling transients, turbulent models and dynamic equations for unsteady flow through closed conduits. The contents of the book are designed to help both students and teachers in carrying out turbulent flow analysis and solving problems in engineering and hydraulic applications.

Key Features

- all the basic concepts in turbulent flow are clearly identified and presented in a simple manner with illustrative and practical examples.

- includes a self-contained approach to the subject, indicating prerequisite materials and information needed from courses.

- each chapter also has a set of questions and problems to test the student’s power of comprehending the topics.

- provides an exhaustive appendix on interesting examples

Turbulent Flow and Boundary Layer Theory: Selected Topics and Solved Problems a useful textbook for students of engineering. It also serves as a quick reference for professionals, researchers and project consultants involved with processes that require turbulent flow and boundary layer methods analysis.

This book explains uncertainty analysis for finite elements and general nonlinear problems. It starts with the fundamentals of the topic and progresses to complex methods through 9 chapters. Each chapter focuses on a specific, relevant topic and provides information in a structured reading format for advanced learners. The author explains different models relevant to the topic where applicable, in an effort to cover the diverse aspects of mathematical analysis.

Topics covered in the book include:

- Nonlinear stochastic finite element methods

- Reliability calculations

- Static analysis of interval finite element

- Linear and nonlinear vibration analysis

- Stochastic, random, fuzzy and mixed fields

- Mixed finite element analysis

Uncertainty Analysis in Finite Elements Models is an ideal reference for advanced courses in mathematical analysis and engineering that require students to understand the basics of uncertainty analysis and basic reliability calculations.

Stroke is one of the most debilitating diseases which poses a significant economic burden on society. Increasing exposure to behavioural risk factors for stroke (tobacco use, unhealthy diet, physical inactivity and excessive alcohol consumption) and air pollution are driving up the worldwide stroke burden. Although medical interventions to prevent and manage stroke have advanced considerably over the last two decades, they are not consistently implemented worldwide. Therefore, health outcomes of stroke treatment vary throughout the world.

The need for the development of biomaterials as scaffold for tissue regeneration is driven by the increasing demands for materials that mimic functions of extracellular matrices of body tissues. Unfolding the Biopolymer Landscape provides a unique account of "biopolymeric interventions" inherent to biotechnological applications, soft tissue engineering, ophthalmic drug delivery, biotextiles, environmentally responsive systems, neurotherapeutics, and emulsions-based formulations for food and pharmaceutical applications. Chapters in this volume also cover biomedical applications and implications of cationic polymers, collagen-based substrates, multifunctional polymers, shape memory biopolymers, hybrid semisynthetic biomaterials, microbial exopolysaccharides, biomaterials mimicking the extracellular microenvironment, derivatized polysaccharides, and metallic biomaterials.

Each chapter is distinctly written by experts in the respective fields and emphasis is given on the mechanistic profile of the performance of biopolymers and biomedical applications. This book provides both basic and advanced biopolymer information for scientific experts and early career researchers in the field of drug delivery, tissue engineering, nanomedicine, food technology, peptide science, biomaterial design, and nutrition.

This volume provides a unique account of "biopolymeric interventions" inherent to biotechnological applications, soft tissue engineering, ophthalmic drug delivery, biotextiles, environmentally responsive systems, neurotherapeutics, and emulsions-based formulations for food and pharmaceutical applications.

Many viruses are known to persist in their host’s cells in a latent state without exhibiting virulence or symptoms of infection, hence, giving rise to the term ‘latent infections’. Vaccines for Latent Viral Infections is a clear and concise monograph which features a review of some well-known viruses that are capable of establishing latent infections in humans. These include herpes simplex virus (HSV), cytomegalovirus (CMV), varicella zoster virus (VZV), Epstein-Barr virus (EBV) and human immunodeficiency virus (HIV).The book also highlights common features of each of these viruses and demonstrates how they are able to evade the host’s immune response. This brief monograph finally proposes a much needed shift in the approach to designing vaccines that will prevent establishment of virus latency.

Vaccines for Latent Viral Infections serves as a handy reference for researchers interested in the basic virology of viruses capable of latent infections, the immune responses to these infections and the development of vaccines to tackle these pathogens.

Herbal Medicine: Back to the Future compiles expert reviews on the application of herbal medicines (including Ayurveda, Chinese traditional medicines and alternative therapies) to treat different ailments. The book series demonstrates the use of sophisticated methods to understand traditional medicine, while providing readers a glimpse into the future of herbal medicine.

The second volume in the series continues on the theme of the previous volume, focusing on herbal remedies for cardiovascular health. The topics included in this volume are:

Plants used for treating cardiovascular diseases in the Iberian Peninsula and Balearic Islands

Herbal products for treating hypertension and hyperlipidemia

Medicinal plants and the Mediterranean diet for treating obesity related cardiovascular disorders

Traditional Indian cardiovascular medicine

This volume is essential reading for all researchers in the field of ethnobotany, natural product chemistry, nutrition and pharmacology. Medical professionals involved in cardiology and internal medicine who seek to improve their knowledge about herbal medicine and alternative therapies will also benefit from the contents of the volume.

This book provides a comprehensive exploration of vector-borne diseases, highlighting current trends, control strategies, and their public health implications. With contributions from experts, it informs readers about specific diseases caused by vectors such as mosquitoes and other zoonotic agents, presenting innovative approaches for prevention and management.

The book begins with a focus on mosquito control strategies, emphasizing their significance in reducing the burden of vector-borne diseases. It further unravels the impact of Rickettsial infections, providing insights into these often-underdiagnosed diseases. Scrub typhus is explored through its co-infections with other vector-borne zoonotic diseases and analyzed using an integrated omics approach to better understand its pathogenesis and treatment. The final chapter sheds light on lymphatic filariasis, a neglected tropical disease, covering its endemic nature, clinical manifestations like elephantiasis and hydrocele, mass drug administration programs, and novel vector management techniques.

This resource is ideal for public health professionals, researchers, and students, providing actionable insights into combating vector-borne diseases globally.

Key Features:

Discusses innovative mosquito control strategies and integrated vector management.

Explores lesser-known diseases like scrub typhus and Rickettsial infections with advanced omics approaches.

Provides a detailed analysis of lymphatic filariasis, including treatment strategies like antifilarial drugs and mass drug administration.

Highlights the importance of public health interventions in combating neglected tropical diseases.

This handbook is a guide to numerical and experimental processes that are used to analyze and improve the efficiency of vertical axis rotors. Chapters present information that is required to optimize the geometrical parameters of rotors or understand how to augment upstream water velocity.

The authors of this volume present a numerical model to characterize the water flow around the vertical axis rotors using commercial CFD code in Ansys Fluent®. The software has been used to select adequate parameters and perform computational simulations of spiral Darrieus turbines. The contents of the volume explain the experimental procedure carried out to evaluate the performance of the spiral Darrieus turbine, how to characterize the water flow in the vicinity of the tested turbine, and the method to assess the spiral angle influence on the turbine performance parameters. Results for different spiral angles (ranging from 10° to 40°) are presented.

This volume is a useful handbook for engineers involved in power plant design and renewable energy sectors who are studying the computational fluid dynamics of vertical axis turbines (such as Darrieus turbines) that are used in hydropower projects.

Key features:

- 4 chapters that cover the numerical and experimental analysis of vertical axis rotors and hydrokinetic turbines

- Simple structured layout for easy reading (methodology, models and results)

- Bibliographic study to introduce the reader to the subject

- A wide range of parameters included in experiments

- A comprehensive appendix of tables for mechanical parameters, statistical models, rotor parameters and geometric details.

This video atlas covers a broad range of spinal surgical procedures. The volume includes a collection of high quality 3-to-8 minute videos of some of the most critical spine operations performed by internationally renowned expert surgeons.

Key features of the book contents include:

o Downloadable high quality video content with subtitles suitable for viewing on any display (A brief preview of the book content can be viewed at https://www.youtube.com/watch?v=SxMi4UFj7HA )

o Detailed descriptions of surgical indications, preoperative planning, patient positioning, surgical technique, complications, postoperative care and outcomes for each procedure

o Full color images and illustrations highlighting different key stages of each surgical technique

The video format allows skill development of its intended audience by conveying temporal and spatial details which often go unnoticed in photograph format. This volume will be of immense interest to both the novice and the experienced spinal surgeon as they can benefit from the visual guides presented in the book. It also serves as an ideal teaching tool for spine surgery units in medical schools.